DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and PAX1

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_006183.2	Gene:	PAX1 / 5075	HGNCID:	8615	Length:	534	Species:	Homo sapiens

Alignment Length:	220	Identity:	46/220 - (20%)
Similarity:	64/220 - (29%)	Gaps:	65/220 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 EPEESHRQSSSSPSTKSCCDGSILACCSFPHCFSQANAESRRFGHATLPPTFTPTSSHTYPFVGL 147
            |.:..:.||:|:.|..    |..|..|::|        .|.:.|              .|...|.
Human   346 EADIKYTQSASTLSAV----GGFLPACAYP--------ASNQHG--------------VYSAPGG 384

  Fly   148 DKLFPGPYMDYKSVLRPTPIRAAEHAAPTYPTLATN-----ALLRFHQHQKQQHQQHHHHQHHPK 207
            ..|.|||         |.|.......||....:|.:     |.:.|                  |
Human   385 GYLAPGP---------PWPPAQGPPLAPPGAGVAVHGGELAAAMTF------------------K 422

  Fly   208 HLHQQHKPPPHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQ-QLLDIAPTSPAAAAAATSQN 271
            |      |....|..|.|......|:.......:.:...|.:|: :........|.|...|.:..
Human   423 H------PSREGSLPAPAARPRTPSVAYTDCPSRPRPPRGSSPRTRARRERQADPGAQVCAAAPA 481

  Fly   272 GAHGHGGGNGQGNASAGSNGKRKRS 296
            ...|..||..:..||||..|.|..|
Human   482 IGTGRIGGLAEEEASAGPRGARPAS 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475
PAX1	NP_006183.2	PAX	98..225	CDD:238076
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	101..157
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	176..224
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..480		10/55 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..511		7/15 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910