DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and NKX6-1

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_006159.2	Gene:	NKX6-1 / 4825	HGNCID:	7839	Length:	367	Species:	Homo sapiens

Alignment Length:	407	Identity:	98/407 - (24%)
Similarity:	132/407 - (32%)	Gaps:	140/407 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SAASMEQSMPENLSTHMYGECEVNPT-------------LAKCPDPVNVDHELPTKESCASTTIV 57
            |::|...|....|.||..|..:...|             .|..|..:|.....|:....:...:.
Human    52 SSSSSSSSPSPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALP 116

  Fly    58 STSPTSATSTTKVKLSFSVDRLLGSEPEESHRQSSSSPSTKSCCDGSILACCSFPHCFSQANAES 122
            |.||:                  ||....|...|:||.|..:....:..|..|.|   :...|..
Human   117 SASPS------------------GSSSSSSSSASASSASAAAAAAAAAAAAASSP---AGLLAGL 160

  Fly   123 RRFGHATLPPTFTPTSSHTYPFVGLDKLFPGPYMDYKSVLRPTPIRAAEHAAPTYPTLATNALLR 187
            .||...:.||.         |        ||.|.        :|..||..|...||
Human   161 PRFSSLSPPPP---------P--------PGLYF--------SPSAAAVAAVGRYP--------- 191

  Fly   188 FHQHQKQQHQQHHHHQHHPKHLHQQHKPPPHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQ 252
                                      ||           ||.|.               |:||..
Human   192 --------------------------KP-----------LAELP---------------GRTPIF 204

  Fly   253 LLDIAPTSP--AAAAAATSQNGAHGHGGGNGQGNASAGSNGKRKRSWSRAVFSNLQRKGLEIQFQ 315
            ...:..:.|  .|..|.|..           ||:.....:||||.  :|..||..|...||..|:
Human   205 WPGVMQSPPWRDARLACTPH-----------QGSILLDKDGKRKH--TRPTFSGQQIFALEKTFE 256

  Fly   316 QQKYITKPDRRKLAARLNLTDAQVKVWFQNRRMKWR--HTRENLKSGQEKQPSAVPESGGVFKTS 378
            |.||:..|:|.:||..|.:|::||||||||||.|||  |..| :.:.::||.|......|.  :.
Human   257 QTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAE-MATAKKKQDSETERLKGA--SE 318

  Fly   379 TPSGDGTPQEALDYSSD 395
            ....|....:.||.:||
Human   319 NEEEDDDYNKPLDPNSD 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	27/52 (52%)
NKX6-1	NP_006159.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..133		18/98 (18%)
		Repressor domain. /evidence=ECO:0000250	102..268		59/285 (21%)
		Homeobox	239..293	CDD:395001	28/53 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..367		11/45 (24%)
		Involved in DNA-binding. /evidence=ECO:0000250	306..367		8/32 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910