DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment H2.0 and ZFHX3

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001373664.1	Gene:	ZFHX3 / 463	HGNCID:	777	Length:	3703	Species:	Homo sapiens

Alignment Length:	521	Identity:	104/521 - (19%)
Similarity:	159/521 - (30%)	Gaps:	189/521 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 VNPTLAKCPDPVNVDHELPTKESCASTTIVSTSPTSA----TSTTKVKLSFSVDRLLGSE----- 83
            :.||.:.|..|      :|::...|.....:.:.:||    |:..:...:|:.....|.|
Human  2375 LTPTSSSCSTP------MPSQAYSAPAPSANNTASSAFLQLTAEAEELATFNSKTEAGDEKPKLA 2433

  Fly    84 ------------------PE----ESHRQSSSSPSTKSCCDGSILACCSFPHCFSQANAESRRFG 126
                              ||    |...|.:::|..|.   ..:::..|.|.
Human  2434 EAPSAQPNQTQEKQGQPKPELQQQEQPEQKTNTPQQKL---PQLVSLPSLPQ------------- 2482

  Fly   127 HATLPPTFTPTSSHTYPFVGLDKLFPGP----YMDYKSVLRPTPIRAAEHAAPTYPTLATNALLR 187
                ||...|.     |...|.:..|.|    ::..|.:...||.:.|.......|.......|.
Human  2483 ----PPPQAPP-----PQCPLPQSSPSPSQLSHLPLKPLHTSTPQQLANLPPQLIPYQCDQCKLA 2538

  Fly   188 FHQHQK-QQHQQHH----HHQH-HPKHLHQQHKPP-----PHNSTTASALLA------PLHSLTS 235
            |...:. |:|||.|    .:|. ||:.|.:....|     |.|...||.||:      |..|.||
Human  2539 FPSFEHWQEHQQLHFLSAQNQFIHPQFLDRSLDMPFMLFDPSNPLLASQLLSGAIPQIPASSATS 2603

  Fly   236 LQLTQQQQRFLGKTPQQLLDIAPTSPAAAAAATSQNGAHGHGGGNGQGNASAGSNGKRKRSWSRA 300
                       ..||...::.........|:|:......|.||...|       ..||.|
Human  2604 -----------PSTPTSTMNTLKRKLEEKASASPGENDSGTGGEEPQ-------RDKRLR----- 2645

  Fly   301 VFSNLQRKGLEIQFQQQKYITKPDRRKL---AARLNLTDAQVKVWFQNRR--------------- 347
              :.:..:.|||.:|:....:.|.|:.|   |..:.|....|:|||||.|
Human  2646 --TTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQFRAVGPAQ 2708

  Fly   348 ---------------------MKWRHTRENLKSGQEKQPSA--------VPESGGVF-------- 375
                                 ::.||..|..::|.....||        :...|.:|
Human  2709 AHRRCPFCRALFKAKTALEAHIRSRHWHEAKRAGYNLTLSAMLLDCDGGLQMKGDIFDGTSFSHL 2773

  Fly   376 KTSTPSGDGTPQEAL-----------------------DYSSDSCSSVDLS---EQADEDDNIEI 414
            ..|:..|.|.|...:                       |:.|.|.|||:|:   .:.|.||...:
Human  2774 PPSSSDGQGVPLSPVSKTMELSPRTLLSPSSIKVEGIEDFESPSMSSVNLNFDQTKLDNDDCSSV 2838

  Fly   415 N 415
            |
Human  2839 N 2839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	16/91 (18%)
ZFHX3	NP_001373664.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..128
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	417..536
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	588..619
		C2H2 Zn finger	673..693	CDD:275368
		C2H2 Zn finger	728..745	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1148..1214
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1303..1354
		C2H2 Zn finger	1362..1385	CDD:275368
		C2H2 Zn finger	1403..1423	CDD:275371
		C2H2 Zn finger	1431..1452	CDD:275371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1490..1529
		C2H2 Zn finger	1547..1571	CDD:275368
		C2H2 Zn finger	1598..1616	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1629..1727
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1865..1938
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2030..2082
		HOX	2145..2201	CDD:197696
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2204..2244
		Homeobox	2245..2299	CDD:395001
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2376..2400		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2422..2520		20/122 (16%)
		COG5576	2594..2738	CDD:227863	33/168 (20%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:24651376	2615..2617		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2619..2647		9/41 (22%)
		Homeobox	2645..2698	CDD:395001	17/59 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2771..2796		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2841..2871
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2912..2947
		Homeobox	2950..3003	CDD:395001
		Herpes_BLLF1	<3104..>3191	CDD:282904
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3137..3267
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3386..3449
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3565..3703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910