DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and zfh2

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_524623.2	Gene:	zfh2 / 43795	FlyBaseID:	FBgn0004607	Length:	3005	Species:	Drosophila melanogaster

Alignment Length:	469	Identity:	93/469 - (19%)
Similarity:	161/469 - (34%)	Gaps:	124/469 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ESAASMEQ--SMPENLSTHMYGECEVNPTLAKCPDPVNVDH------ELPTKESCASTTIVSTSP 61
            ||...|.|  ::|..:..|.:..............|.|.::      .|...|......:...:.
  Fly  1825 ESIMEMSQKANLPMKVVKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYERTGQAKVTPLND 1889

  Fly    62 TSATSTTKVKLSFSVDRLLGSEPEESHRQSSSSPSTKSCCDGSILACCSFPHCFSQANAESRRFG 126
            |.:.:.|....|.::     |.|...:...||..:..|    .:||.       .:|||......
  Fly  1890 TCSVAVTGPMTSSTI-----SLPPSGNINLSSKENATS----KVLAA-------GKANASGPVTF 1938

  Fly   127 HATLP-------PTFTPTSSHTYPFVGLDKLFPG---------PYM---DYKSVLRPTPIRAAEH 172
            .||:|       |..|.:|.:...::| :.:|.|         ||.   ..||..:...|.|.:.
  Fly  1939 SATVPVSTPLSRPESTNSSGNISDYIG-NNIFFGQLGSKEQILPYSLDGQIKSEPQDDMIGATDF 2002

  Fly   173 AAPTY--------------------------------------PTLATNALLRFHQHQKQQHQQH 199
            |..|.                                      .:||:|.       |.||....
  Fly  2003 AYQTKQHSSFSFLKQQQDLVDPPEQCLTNQNADTAQDQSLLAGSSLASNC-------QSQQQINI 2060

  Fly   200 HHHQHHPKHLHQQHKPPPHNSTTASALLAPLHSLTSLQLTQ--------QQQRFLGKTPQQLLDI 256
            ...:..........:||..||..|..:...::.|.:.||..        ::.:.:|||.::  ::
  Fly  2061 FETKSESGSSDVLSRPPSPNSGAAGNVYGSMNDLLNQQLENMGSNMGPPKKMQIVGKTFEK--NV 2123

  Fly   257 APTSPAAAAAATSQNGAHGHGGGNGQGNASAGSNGKRKRSWSRAVFSNLQRKGLEIQFQQQKYIT 321
            ||...:.:.:...::.:     .|...::|:.|.|||.   :|..|::.|.|.|:..|:...|..
  Fly  2124 APMVTSGSVSTQFESNS-----SNSSSSSSSTSGGKRA---NRTRFTDYQIKVLQEFFENNSYPK 2180

  Fly   322 KPDRRKLAARLNLTDAQVKVWFQNRRMKWRHTRENLKSGQEKQPSAVPESGGVFKTSTPSGDGTP 386
            ..|...|:..|.|:...:.|||||.|.|.|...||       ||     :..:|:     .:.|.
  Fly  2181 DSDLEYLSKLLLLSPRVIVVWFQNARQKQRKIYEN-------QP-----NNTLFE-----NEETK 2228

  Fly   387 QEALDYSSDSCSSV 400
            ::.::|:...|:.|
  Fly  2229 KQNINYACKKCNLV 2242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	18/52 (35%)
zfh2	NP_524623.2	C2H2 Zn finger	561..581	CDD:275368
		C2H2 Zn finger	616..633	CDD:275368
		C2H2 Zn finger	1515..1542	CDD:275371
		C2H2 Zn finger	1543..1564	CDD:275371
		HOX	1797..1853	CDD:197696	6/27 (22%)
		Homeobox	2158..2210	CDD:278475	18/51 (35%)
		Homeobox	2764..2816	CDD:278475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I3555
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910