DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment H2.0 and pitx3

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_991238.1	Gene:	pitx3 / 402974	ZFINID:	ZDB-GENE-041229-4	Length:	293	Species:	Danio rerio

Alignment Length:	119	Identity:	41/119 - (34%)
Similarity:	58/119 - (48%)	Gaps:	18/119 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 LLDIAPTSPAAAAAATSQNGAHGHGGG-NGQGNA------------SAGSNG--KRKRSWSRAVF 302
            |.|....||   |.:.|.:|...|..| .||.|:            |...:|  |:|:...|..|
Zfish     6 LTDSEARSP---ALSLSDSGTPQHDPGCKGQDNSDTEKSHQNHTDESNPEDGSLKKKQRRQRTHF 67

  Fly   303 SNLQRKGLEIQFQQQKYITKPDRRKLAARLNLTDAQVKVWFQNRRMKWRHTREN 356
            ::.|.:.||..||:.:|.....|.::|...|||:|:|:|||:|||.|||....|
Zfish    68 TSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERN 121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	22/52 (42%)
pitx3	NP_991238.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..69		18/65 (28%)
		Cnd2	18..>79	CDD:303063	16/60 (27%)
		Homeobox	64..116	CDD:278475	22/51 (43%)
		OAR	251..268	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	255..268
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O35160	260..264
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910