DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and BARHL2

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_064447.1	Gene:	BARHL2 / 343472	HGNCID:	954	Length:	387	Species:	Homo sapiens

Alignment Length:	348	Identity:	90/348 - (25%)
Similarity:	112/348 - (32%)	Gaps:	138/348 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 SFSVDRLLGSEPEESHRQSSSSPSTKSCCDGSILACCSFPHCFSQANAESRRFGHATLPPTFTPT 137
            ||.:|.:|.|       .||.||                    ...|.:.|..|.|..
Human    10 SFGIDTILSS-------ASSGSP--------------------GMMNGDFRPLGEART------- 40

  Fly   138 SSHTYPFVGLDKLFPGPYMDYKSVLRPTPIRAAE--HAAPTYPTLATNALLRFHQHQKQQHQQHH 200
                              .|::|...|:|....:  ..||:.|...|  :.....|......|||
Human    41 ------------------ADFRSQATPSPCSEIDTVGTAPSSPISVT--MEPPEPHLVADATQHH 85

  Fly   201 HHQHHPKHLHQQHKPPPHNSTTASALLAPLHSLTSLQLTQQQQRFLGK-----TPQQLLDIA--- 257
            ||.|     |.|..|||        ..||..||.  .|.||||....:     .||||...|
Human    86 HHLH-----HSQQPPPP--------AAAPTQSLQ--PLPQQQQPLPPQQPPPPPPQQLGSAASAP 135

  Fly   258 --------------PTSPAAAAAATSQNGAHGHGGGNGQGNA-------------SAGSNGKRKR 295
                          .:.|.||.|..|.:.:..|.....:.||             |.....||:.
Human   136 RTSTSSFLIKDILGDSKPLAACAPYSTSVSSPHHTPKQESNAVHESFRPKLEQEDSKTKLDKRED 200

  Fly   296 SWS--------------------------------RAVFSNLQRKGLEIQFQQQKYITKPDRRKL 328
            |.|                                |..||:.|...||..|::|||::..||..|
Human   201 SQSDIKCHGTKEEGDREITSSRESPPVRAKKPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDL 265

  Fly   329 AARLNLTDAQVKVWFQNRRMKWR 351
            ||.|||||.|||.|:||||.||:
Human   266 AAALNLTDTQVKTWYQNRRTKWK 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	30/84 (36%)
BARHL2	NP_064447.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..145		47/203 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..240		11/82 (13%)
		Homeobox	236..288	CDD:278475	29/51 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..387
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810