Protein Alignment H2.0 and TLX2

DIOPT Version :9

• Sequence 1: NP_523488.2
• Gene: H2.0 / 33841
• FlyBaseID: FBgn0001170
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: NP_057254.1
• Gene: TLX2 / 3196
• HGNCID: 5057
• Length: 284
• Species: Homo sapiens
• Alignment Length: 196
• Identity: 54/196 - (27%)
• Similarity: 74/196 - (37%)
• Gaps: 57/196 - (29%)

  Fly   261 PAAAAAATSQNGAHGHGGGNGQGNASAG------SNGKR-------------------------- 293
            |..|..|.:..|..|.||..|    .||      .:|:|
Human    92 PPPAGGAPAVPGPSGLGGAGG----LAGLTFPWMDSGRRFAKDRLTAALSPFSGTRRIGHPYQNR 152

  Fly   294 ---KRSWSRAVFSNLQRKGLEIQFQQQKYITKPDRRKLAARLNLTDAQVKVWFQNRRMKW-RHTR 354
               ||...|..||..|...||.:|.:|||:...:|..||..|.:||||||.||||||.|| |.|.
Human   153 TPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTA 217

  Fly   355 ENLKSGQEK--------QPSAVPESGGVFKTSTPSGDGTPQEALDYSSDSCSSVDLSEQADEDDN 411
            |..::.:.:        |..|:|.         |.....|.:.|...:.|..::...:...||:.
Human   218 EEREAERHRAGRLLLHLQQDALPR---------PLRPPLPPDPLCLHNSSLFALQNLQPWAEDNK 273

  Fly   412 I 412
            :
Human   274 V 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	28/53 (53%)
TLX2	NP_057254.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..106		4/13 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	139..166		4/26 (15%)
		Homeobox	160..213	CDD:278475	27/52 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810