DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment H2.0 and Arx

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001093644.1	Gene:	Arx / 317268	RGDID:	1562672	Length:	566	Species:	Rattus norvegicus

Alignment Length:	190	Identity:	66/190 - (34%)
Similarity:	92/190 - (48%)	Gaps:	42/190 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 QLTQQQQRFLGKTPQQLLDIAPTSPAAAAAATSQNGA-----------------HGHG--GGNGQ 282
            :|.:...|.|.|.|:: ..:|.|...|||||.:...|                 |...  |.:|:
  Rat   249 ELLEDDARALLKEPRR-CSVATTGTVAAAAAAAAAAAAVATEGGELSPKEELLLHPEDAEGKDGE 312

  Fly   283 GNA--SAGSNG-----KRKRSWSRAVFSNLQRKGLEIQFQQQKYITKPD---RRKLAARLNLTDA 337
            .:.  ||||:.     |||:...|..|::.|.:.||..||:..|   ||   |.:||.||:||:|
  Rat   313 DSVCLSAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHY---PDVFTREELAMRLDLTEA 374

  Fly   338 QVKVWFQNRRMKWRHTRENLKSGQEKQPSAVPESGGVFKTS--TPSGDGTP----QEALD 391
            :|:|||||||.||| .||  |:|.:..|..:|..|.:..|.  :|..|.:|    ..|||
  Rat   375 RVQVWFQNRRAKWR-KRE--KAGAQTHPPGLPFPGPLSATHPLSPYLDASPFPPHHPALD 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	27/55 (49%)
Arx	NP_001093644.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..79
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..264		5/14 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..319		3/32 (9%)
		Homeobox	336..388	CDD:278475	27/54 (50%)
		OAR	530..547	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	534..547
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910