DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and Zfhx4

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	XP_006232224.1	Gene:	Zfhx4 / 310250	RGDID:	1563022	Length:	3619	Species:	Rattus norvegicus

Alignment Length:	435	Identity:	94/435 - (21%)
Similarity:	142/435 - (32%)	Gaps:	122/435 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PVNVDHELPTKESCASTTIVSTSPTSATSTTKVKLSFSVDRLLGSEPEESHRQS--------SSS 94
            |..|..:..|.:|.|:....|.|.||.......|.....:......|.|..:|:        .|:
  Rat  2368 PCTVSGQTDTAKSTAAPVASSGSGTSTPLIPSPKPEPEKNSPKPEYPAEKTKQNDPSLPQGIKSA 2432

  Fly    95 PSTKSCCDGSILACCSFPHCFSQANAESRRFGHATLPP----TFTPTSSHTYPFVGLDKLFPGPY 155
            ||:.|.......|..|.|.  .|...:.:..|.   ||    |..|:|........:....|...
  Rat  2433 PSSVSTSSEPQQASISQPP--PQLPKQPQLIGR---PPSASQTPIPSSPLQISMTSIQNSLPPQL 2492

  Fly   156 MDYKSVLRPTPIRAAEHAAPTYPTLATNALLRFHQHQKQQHQQHHHHQH-HPKHLHQQHKPP--- 216
            :.|          ..:.....:|||   .|.:.|||   .|.....:|. |...|.:....|
  Rat  2493 LQY----------PCDQCTIAFPTL---ELWKEHQH---MHFLAAQNQFLHSPFLERPMDMPYMI 2541

  Fly   217 --PHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQLLDIAPTSPAAAAAATSQ--------N 271
              |:|......||.  .|||.:             |.|......|:||:.||:..:        |
  Rat  2542 FDPNNPLMTGQLLG--SSLTQM-------------PPQASTAHTTAPASVAASLKRKLDDKEDNN 2591

  Fly   272 GAHGHGGGNGQGNASAGSNGKRKRSWSRAVFSNLQRKGLEIQFQQQKYITKPDRRKL---AARLN 333
            .:...||.:|:..    ...||.|       :.:..:.|||.:::....:.|.|:.|   |..:.
  Rat  2592 CSEKEGGNSGEDQ----HRDKRLR-------TTITPEQLEILYEKYLLDSNPTRKMLDHIAREVG 2645

  Fly   334 LTDAQVKVWFQNRR------------------------------------MKWRHTRENLKSGQE 362
            |....|:|||||.|                                    ::.||..|..::|..
  Rat  2646 LKKRVVQVWFQNTRARERKGQFRAVGPAQSHKRCPFCRALFKAKSALESHIRSRHWNEGKQAGYS 2710

  Fly   363 KQPSAVPESGGVFKTSTPSGDGTPQEAL--DYSSDSCSSVDLSEQ 405
            ..||.:        .||..|..:||:.:  ||.|...:.:|||.:
  Rat  2711 LPPSPL--------ISTEDGGESPQKYIYFDYPSLPLTKIDLSSE 2747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	15/91 (16%)
Zfhx4	XP_006232224.1	C2H2 Zn finger	620..641	CDD:275368
		C2H2 Zn finger	651..672	CDD:275368
		C2H2 Zn finger	706..723	CDD:275368
		C2H2 Zn finger	1404..1424	CDD:275371
		C2H2 Zn finger	1432..1449	CDD:275371
		SFP1	<1489..1616	CDD:227516
		C2H2 Zn finger	1548..1572	CDD:275368
		C2H2 Zn finger	1600..1618	CDD:275368
		COG5576	2106..2245	CDD:227863
		HOX	2135..2190	CDD:197696
		Homeobox	2234..2288	CDD:395001
		PspC_subgroup_1	<2398..>2476	CDD:411407	17/82 (21%)
		COG5576	2544..>2666	CDD:227863	36/147 (24%)
		Homeobox	2611..2664	CDD:395001	16/59 (27%)
		Homeobox	2934..2987	CDD:395001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910