DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and Nkx2-3

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001101064.1	Gene:	Nkx2-3 / 309389	RGDID:	1308521	Length:	362	Species:	Rattus norvegicus

Alignment Length:	248	Identity:	64/248 - (25%)
Similarity:	94/248 - (37%)	Gaps:	61/248 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 QQHHHHQHH-----PKHLHQQHKPPPHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQLLDI 256
            ||.|.|..|     .:|||           :|..:||...........::.:...|:....|..:
  Rat    22 QQRHFHGAHLQAELEQHLH-----------SAPCMLAAAEGTQFSDAGEEDEEEEGEKLSYLNSL 75

  Fly   257 APTSPAAAAAATSQNGAH-----GHGGGNGQ----------------------GNASAGSNGKRK 294
            |.......:....|:..|     ...|...|                      |:..|..:|:|.
  Rat    76 AAAEGHGVSGLCPQSYVHTVLRDSCSGPKEQEEEVVSERSQKSCQLKKSLEAAGDCKASEDGERP 140

  Fly   295 RSWS----RAVFSNLQRKGLEIQFQQQKYITKPDRRKLAARLNLTDAQVKVWFQNRRMKWRHTRE 355
            :..|    |.:||..|...||.:|:||:|::.|:|..||:.|.||..|||:||||||.|.:..|:
  Rat   141 KPRSRRKPRVLFSQAQVFELERRFKQQRYLSAPEREHLASSLKLTSTQVKIWFQNRRYKCKRQRQ 205

  Fly   356 --NLKSGQEKQPS-----AVP---ESGGVFKTSTPSGDGTP----QEALDYSS 394
              :|:.|....|.     |||   ..|....|.:....|:|    ..|..|:|
  Rat   206 DKSLELGTHAPPPPPRRVAVPVLVRDGKPCVTPSAQAYGSPYGVGAGAYSYNS 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	28/56 (50%)
Nkx2-3	NP_001101064.1	Homeobox	148..202	CDD:395001	27/53 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910