DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment H2.0 and Zfhx3

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	XP_038954238.1	Gene:	Zfhx3 / 307829	RGDID:	1560268	Length:	3730	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	109/515 - (21%)
Similarity:	164/515 - (31%)	Gaps:	176/515 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 VNPTLAKCPDPVNVDHELPTKESCASTT----IVSTSPTSATSTTKVKLSFSVDRLLGSEP---- 84
            :.||.:.|..|:..........|.|||.    :..|:.|...:|...|...|.::...::|
  Rat  2386 LTPTSSSCSTPMPSQAYSTPAPSSASTAPSAFLQLTAETDELATFNSKAEASDEKPKQADPPSVQ 2450

  Fly    85 -----------------EESHRQSSSSPSTKSCCDGSILACCSFPHCFSQANAESRRFGHATLPP 132
                             :|...|.::.|..|.    ..||..|.|.                 ||
  Rat  2451 PNQTQEKQGQPKPEVQQQEQAEQKTNVPQPKL----PQLAAPSLPQ-----------------PP 2494

  Fly   133 TFTPTSSHTYPFVGLDKLFPGP----YMDYKSVLRPTPIRAAEHAAPTYPTLATNALLRFHQHQK 193
            ...|.     |...|.:..|.|    ::..|.:...||.:.|.......|.......|.|...:.
  Rat  2495 PQAPP-----PQCPLPQSSPSPSQLSHLPLKPLHTSTPQQLANLPPQLIPYQCDQCKLAFPSFEH 2554

  Fly   194 -QQHQQHH----HHQH-HPKHLHQQHKPP-----PHNSTTASALLA------PLHSLTSLQLTQQ 241
             |:|||.|    .:|. ||:.|.:....|     |.|...||.||:      |..|.||......
  Rat  2555 WQEHQQLHFLSAQNQFIHPQFLDRSLDMPFMLFDPSNPLLASQLLSGAIPQIPASSATSPSTPTS 2619

  Fly   242 QQRFLGKTPQQLLDIAPTSPAAAAAATSQNGAHGHGGGNGQGNASAGSNGKRKRSWSRAVFSNLQ 306
            ....|.:..::         .|:.|:..:|.:.|.||...|       ..||.|       :.:.
  Rat  2620 TMNTLKRKLEE---------KASGASPGENDSSGTGGEEPQ-------RDKRLR-------TTIT 2661

  Fly   307 RKGLEIQFQQQKYITKPDRRKL---AARLNLTDAQVKVWFQNRR--------------------- 347
            .:.|||.:|:....:.|.|:.|   |..:.|....|:|||||.|
  Rat  2662 PEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQFRAVGPAQAHRRCP 2726

  Fly   348 ---------------MKWRHTRENLKSGQEKQPSA--------VPESGGVFKTST-----PSG-D 383
                           ::.||..|..::|.....||        :...|.:|..::     ||| |
  Rat  2727 FCRALFKAKTALEAHIRSRHWHEAKRAGYNLTLSAMLLDCDGGLQMKGDIFDGTSFSHLPPSGSD 2791

  Fly   384 G--------------TPQEAL-----------DYSSDSCSSVDLS---EQADEDDNIEIN 415
            |              :|:..|           |:.|.|.|||:|:   .:.|.||...:|
  Rat  2792 GQGVPLSPVSKTMELSPRTLLSPSSIKVEGLEDFESPSMSSVNLNFDQTKLDNDDCSSVN 2851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	16/91 (18%)
Zfhx3	XP_038954238.1	C2H2 Zn finger	672..692	CDD:275368
		C2H2 Zn finger	727..744	CDD:275368
		C2H2 Zn finger	1374..1394	CDD:275368
		C2H2 Zn finger	1412..1432	CDD:275371
		C2H2 Zn finger	1440..1461	CDD:275371
		C2H2 Zn finger	1556..1580	CDD:275368
		C2H2 Zn finger	1607..1625	CDD:275368
		HOX	2156..2212	CDD:197696
		Homeobox	2256..2310	CDD:395001
		COG5576	2604..2750	CDD:227863	33/168 (20%)
		Homeobox	2657..2710	CDD:395001	17/59 (29%)
		Homeobox	2961..3014	CDD:395001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910