DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and dlx3b

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_571397.2	Gene:	dlx3b / 30585	ZFINID:	ZDB-GENE-980526-280	Length:	269	Species:	Danio rerio

Alignment Length:	282	Identity:	66/282 - (23%)
Similarity:	101/282 - (35%)	Gaps:	65/282 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 SSHTYPFVGLDKLFPGPYMDYKSVLRPTPIRAAEHAAPTYPTLATNALLRFHQHQKQQHQQHHHH 202
            |..||     |:..||...|....:...|   ....:||.|..:...:        ..:..||.:
Zfish     2 SGPTY-----DRKIPGISTDLSGSMSCHP---TSKDSPTLPESSATDM--------GYYSSHHEY 50

  Fly   203 QHHPKHLHQQHKPPPHNSTTASALLAPLHSLTSLQLTQQQQ-----RFLGKTPQQLLDIAPTSPA 262
            ...|.:..|.:.....|.:...|......:.|.......:|     |.|...||..:...|.:..
Zfish    51 YQSPPYPQQMNSYHQFNLSGMGATPGAYPTKTEYPYNTYRQYGHYNRDLQTPPQSAVKEEPETEV 115

  Fly   263 AAAAATSQNGAHGHGGGNGQGNASAGSNGKRKR-SWSRAVFSNLQRKGLEIQFQQQKYITKPDRR 326
            ...                        |||.|: ...|.::|:.|...|:.:||:.:|:..|:|.
Zfish   116 RMV------------------------NGKPKKIRKPRTIYSSYQLAALQRRFQKAQYLALPERA 156

  Fly   327 KLAARLNLTDAQVKVWFQNRRMKWRHTRENLKSGQEKQPSA-------VPESGGVFKTST----- 379
            :|||:|.||..|||:||||||.|::...:|.:...|..|:|       .|.|..|:..:.
Zfish   157 ELAAQLGLTQTQVKIWFQNRRSKFKKLYKNGEVPLEHSPNASDSMACNSPPSPAVWDNNAHSSQV 221

  Fly   380 -------PSGDGTPQEALDYSS 394
                   |....||....|||:
Zfish   222 NRGQIPQPPLSSTPPYMEDYSN 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	25/52 (48%)
dlx3b	NP_571397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		11/46 (24%)
		DLL_N	28..104	CDD:289198	13/83 (16%)
		Homeobox	128..181	CDD:278475	25/52 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..242		10/50 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..269
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910