DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and rx2

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_571301.2	Gene:	rx2 / 30473	ZFINID:	ZDB-GENE-990415-237	Length:	327	Species:	Danio rerio

Alignment Length:	203	Identity:	51/203 - (25%)
Similarity:	83/203 - (40%)	Gaps:	46/203 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 LLAPL--HSLTSLQLTQQQQRFLGKTPQQLLDIAPTSPAAAAAATSQNGAHGHG----------G 278
            ||.|:  |.:...|| ::|::.:...|...|.|...:      ...|:..|..|          .
Zfish    52 LLEPIGTHKVDEDQL-EEQEKQVNSDPYSHLQIPDQT------QQQQSVYHDTGLFSTDKCDADL 109

  Fly   279 GNGQGNASAGSNG---------KRKRSWSRAVFSNLQRKGLEIQFQQQKYITKPDRRKLAARLNL 334
            |:.:.|..:.|..         |:|...:|..|:..|...||..|::..|.....|.:||.::||
Zfish   110 GDPRSNVESDSRSPDIPDEDQPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNL 174

  Fly   335 TDAQVKVWFQNRRMKWRHTRENLKSGQEK----------QPSAVPESGGVFKT-------STPSG 382
            .:.:|:|||||||.|||. :|.:.:|..|          :|...|..|.:..:       |:|..
Zfish   175 PEVRVQVWFQNRRAKWRR-QEKMDTGTMKLHDSPIRSFNRPPMAPNVGPMSNSLPLDPWLSSPLS 238

  Fly   383 DGTPQEAL 390
            ..||..::
Zfish   239 SATPMHSI 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	21/52 (40%)
rx2	NP_571301.2	Octapeptide motif	37..44
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..73		7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..139		5/38 (13%)
		Homeobox	139..191	CDD:278475	21/51 (41%)
		OAR	302..316	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	304..317
		Nuclear localization signal. /evidence=ECO:0000255	310..314
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910