DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and hoxd3a

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_571200.1	Gene:	hoxd3a / 30349	ZFINID:	ZDB-GENE-990415-120	Length:	396	Species:	Danio rerio

Alignment Length:	340	Identity:	70/340 - (20%)
Similarity:	119/340 - (35%)	Gaps:	138/340 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PTKESCASTTIVS--TSPTSATSTTKVKLSFSVDRLLGSEPEESHRQSSSSPSTKSCCDGSILAC 108
            ||.:..:|::|.:  .||.....||.|:             :.:|:            :|.|...
Zfish    28 PTHQGFSSSSIENDYQSPICPIQTTSVR-------------QATHK------------NGDINGS 67

  Fly   109 CSFPHCFSQANAESRRFGHATLPPTFTPTSSHTYPFVGLDKLFPGPYMDYKSVLRPTPIRAAEHA 173
            |..|.. ||.|::                                          |..|...:.|
Zfish    68 CMRPSA-SQGNSQ------------------------------------------PESISEQQQA 89

  Fly   174 AP---TYPTLATNALLRFHQHQKQQHQQHHHHQHHPKHLHQQHKPPPHN-STTASALLAPLHSLT 234
            ||   :.|:.:||:.                         |:.|.|..| |:||:.:
Zfish    90 APLAASSPSPSTNST-------------------------QKKKSPSSNGSSTATPV-------- 121

  Fly   235 SLQLTQQQQRFLGKTPQQLLDIAPTSPAAAAAATSQNGAHGHGGGNGQGNASAGSNGKRKRSWSR 299
               :::|...::.:|.|.....:...|||              |......:..|...||.|:
Zfish   122 ---ISKQIFPWMKETRQNAKQKSTNCPAA--------------GETCDDKSPPGPASKRVRT--- 166

  Fly   300 AVFSNLQRKGLEIQFQQQKYITKPDRRKLAARLNLTDAQVKVWFQNRRMKWRHTREN-------L 357
             .:::.|...||.:|...:|:.:|.|.::|..||||:.|:|:||||||||::..:::       |
Zfish   167 -AYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKSKGIMHSPL 230

  Fly   358 KSGQEKQPSAVPESG 372
            ....::.|   |.||
Zfish   231 GHSPDRSP---PLSG 242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	22/52 (42%)
hoxd3a	NP_571200.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..163		40/252 (16%)
		Abdominal-A	116..237	CDD:332641	36/149 (24%)
		Antp-type hexapeptide	126..131		0/4 (0%)
		Homeobox	165..217	CDD:306543	23/55 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..246		5/27 (19%)
		DUF4074	333..394	CDD:315871
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..396
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910