DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and pitx2

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_571050.1	Gene:	pitx2 / 30164	ZFINID:	ZDB-GENE-990714-27	Length:	314	Species:	Danio rerio

Alignment Length:	212	Identity:	57/212 - (26%)
Similarity:	92/212 - (43%)	Gaps:	37/212 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 HHHHQHH---PKHLHQQHKPPPHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQLLDIAPTS 260
            ||||.||   .||                   |||...:|||..|:     ....:..||:...|
Zfish    12 HHHHNHHVTGSKH-------------------APLSMASSLQPLQR-----SVDSKHRLDVHTVS 52

  Fly   261 PAAAAAATSQNGAHGHGGGNGQGNASAGSNGKRKRSWSRAVFSNLQRKGLEIQFQQQKYITKPDR 325
            ..::..:..:.    .|....:.:....|..||:|. .|..|::.|.:.||..||:.:|.....|
Zfish    53 DTSSPESVEKE----KGQSKNEDSNDDPSKKKRQRR-QRTHFTSQQLQELEATFQRNRYPDMSTR 112

  Fly   326 RKLAARLNLTDAQVKVWFQNRRMKWRHTRENLKSGQEKQPSAVPESGGVFKTSTPSGDGTPQEAL 390
            .::|...|||:|:|:|||:|||.||| .||..:..:..:....|:..|:.:   |..|..|....
Zfish   113 EEIAVWTNLTEARVRVWFKNRRAKWR-KRERNQQAELCKNGFGPQFNGLMQ---PYDDMYPSYTY 173

  Fly   391 -DYSSDSCSSVDLSEQA 406
             ::::...:|..||.::
Zfish   174 NNWAAKGLTSASLSTKS 190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	22/52 (42%)
pitx2	NP_571050.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93		25/109 (23%)
		Homeobox	86..138	CDD:278475	22/51 (43%)
		OAR	272..289	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	276..289
		Nuclear localization signal. /evidence=ECO:0000255	282..286
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910