DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and RAX

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_038463.2	Gene:	RAX / 30062	HGNCID:	18662	Length:	346	Species:	Homo sapiens

Alignment Length:	191	Identity:	52/191 - (27%)
Similarity:	75/191 - (39%)	Gaps:	49/191 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 QQQQRFLG------KTPQQLLDIAPTSPAAAAAATSQNGAHGH----------------GGGNGQ 282
            :::.|.||      |.|::  ...|:.|.|.|.|........:                |...|:
Human    61 KERDRRLGARPACPKAPEE--GSEPSPPPAPAPAPEYEAPRPYCPKEPGEARPSPGLPVGPATGE 123

  Fly   283 GNASAGSNGKRKRSWSRAVFSNLQRKGLEIQFQQQKYITKPDRRKLAARLNLTDAQVKVWFQNRR 347
            ...|.....|:|...:|..|:..|...||..|::..|.....|.:||.::||.:.:|:|||||||
Human   124 AKLSEEEQPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRR 188

  Fly   348 MKWRHTRENLK------------SGQEKQPSAV-------PESGGVFKTSTPSGDGTPQEA 389
            .|||. :|.|:            |.....|||.       |.|||     .|:|...|.|:
Human   189 AKWRR-QEKLEVSSMKLQDSPLLSFSRSPPSATLSPLGAGPGSGG-----GPAGGALPLES 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	21/52 (40%)
RAX	NP_038463.2	Octapeptide motif	33..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..145		17/85 (20%)
		Homeobox	140..192	CDD:278475	21/51 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..318		14/55 (25%)
		OAR	319..335	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	323..336
		Nuclear localization signal. /evidence=ECO:0000255	329..333
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910