DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and Pdx1

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_074043.4	Gene:	Pdx1 / 29535	RGDID:	62387	Length:	283	Species:	Rattus norvegicus

Alignment Length:	233	Identity:	62/233 - (26%)
Similarity:	87/233 - (37%)	Gaps:	60/233 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 HHHQHHPKHLHQQHKPP---PHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQLLDIAPTSP 261
            |.|.|.|..|...|.||   |:.:.|...                      :.|.::....|...
  Rat    81 HLHHHLPAQLGLAHPPPGPFPNGTETGGL----------------------EEPSRVHLPFPWMK 123

  Fly   262 AAAAAATSQNGAHGHGGGNGQGNASAGSNGKRKRSWSRAVFSNLQRKGLEIQFQQQKYITKPDRR 326
            :..|.|.....|         |.|.|....:.||  :|..::..|...||.:|...|||::|.|.
  Rat   124 STKAHAWKSQWA---------GGAYAAEPEENKR--TRTAYTRAQLLELEKEFLFNKYISRPRRV 177

  Fly   327 KLAARLNLTDAQVKVWFQNRRMKWRHTRENLKS---------GQE-KQPSAV------------P 369
            :||..||||:..:|:|||||||||:...:..:|         |:| :|..||            |
  Rat   178 ELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRSSGTTSGGGGGEEPEQDCAVTSGEELLALPPPP 242

  Fly   370 ESGGVFKTSTPSG--DGTPQEALDYSSDSCSSVDLSEQ 405
            ..||...:..|:.  :|.....|..|....|...|..|
  Rat   243 PPGGAVPSGVPAAAREGRLPSGLSASPQPSSIAPLRPQ 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	25/52 (48%)
Pdx1	NP_074043.4	Transactivation domain	13..73
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..81		62/233 (27%)
		Antp-type hexapeptide	118..123		1/4 (25%)
		Homeobox	149..203	CDD:395001	26/53 (49%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..283		17/80 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910