DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and OTP

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_115485.1	Gene:	OTP / 23440	HGNCID:	8518	Length:	325	Species:	Homo sapiens

Alignment Length:	231	Identity:	58/231 - (25%)
Similarity:	84/231 - (36%)	Gaps:	68/231 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 HPKHLHQQHKPPPHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQLLDIAPTSPAAAAAATS 269
            ||..|      .|::.....|.|.|...:|:          :|.||..|          |.:|..
Human    41 HPGDL------APNSDPVEGATLLPGEDITT----------VGSTPASL----------AVSAKD 79

  Fly   270 QNGAHGHGGGNGQGNASAGSNGKRKRSWSRAVFSNLQRKGLEIQFQQQKYITKPD---RRKLAAR 331
            .:...|..||.....|.. ..|::|:...|..|:..|...||..|.:..|   ||   |.:||.|
Human    80 PDKQPGPQGGPNPSQAGQ-QQGQQKQKRHRTRFTPAQLNELERSFAKTHY---PDIFMREELALR 140

  Fly   332 LNLTDAQVKVWFQNRRMKWRHTRENLK-----------SGQEKQPSAVPESG------------- 372
            :.||:::|:|||||||.||:..::...           .|..:.|||...:.
Human   141 IGLTESRVQVWFQNRRAKWKKRKKTTNVFRAPGTLLPTPGLPQFPSAAAAAAAAMGDSLCSFHAN 205

  Fly   373 ----------GVFKTSTPSGDGTPQEALDYSSDSCS 398
                      ||.:...|...|. |:|:..|...||
Human   206 DTRWAAAAMPGVSQLPLPPALGR-QQAMAQSLSQCS 240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	24/55 (44%)
OTP	NP_115485.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..112		21/97 (22%)
		Homeobox	107..156	CDD:395001	21/51 (41%)
		OAR	303..320	CDD:397759
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	306..319
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910