DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment H2.0 and Zfhx3

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_031522.2	Gene:	Zfhx3 / 11906	MGIID:	99948	Length:	3723	Species:	Mus musculus

Alignment Length:	502	Identity:	101/502 - (20%)
Similarity:	156/502 - (31%)	Gaps:	149/502 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 VNPTLAKCPDPV-NVDHELPTKESCASTTIVS-----TSPTSATSTTKVKLSFSVDRLLGSEP-- 84
            :.||.:.|..|: :..:..|...:.|:.|..|     |:.|...:|...|...|.::...::|
Mouse  2382 LTPTSSSCSTPMPSQAYSTPAPSAAAANTAPSAFLQLTAETDELATFNSKAEASDEKPKQADPPS 2446

  Fly    85 ----EESHRQSSSSPSTKSCCDGSILACCSFPHCFSQANAESRRFGHATLPPTFTPTSSHTYPFV 145
                :...:|....|..:.          .......:.||...:......|....|......|..
Mouse  2447 AQPNQTQEKQGQPKPEMQQ----------QLEQLEQKTNAPQPKLPQPAAPSLPQPPPQAPPPQC 2501

  Fly   146 GLDKLFPGP----YMDYKSVLRPTPIRAAEHAAPTYPTLATNALLRFHQHQK-QQHQQHH----H 201
            .|.:..|.|    ::..|.:...||.:.|.......|.......|.|...:. |:|||.|    .
Mouse  2502 PLPQSSPSPSQLSHLPLKPLHTSTPQQLANLPPQLIPYQCDQCKLAFPSFEHWQEHQQLHFLSAQ 2566

  Fly   202 HQH-HPKHLHQQHKPP-----PHNSTTASALLA------PLHSLTSLQLTQQQQRFLGKTPQQLL 254
            :|. ||:.|.:....|     |.|...||.||:      |..|.||           ..||...:
Mouse  2567 NQFIHPQFLDRSLDMPFMLFDPSNPLLASQLLSGAIPQIPASSATS-----------PSTPTSTM 2620

  Fly   255 DIAPTSPAAAAAATSQNGAHGHGGGNGQGNASAGSNGKRKRSWSRAVFSNLQRKGLEIQFQQQKY 319
            :.........|:|:......|.||...|       ..||.|       :.:..:.|||.:|:...
Mouse  2621 NTLKRKLEEKASASPGENDSGTGGEEPQ-------RDKRLR-------TTITPEQLEILYQKYLL 2671

  Fly   320 ITKPDRRKL---AARLNLTDAQVKVWFQNRR---------------------------------- 347
            .:.|.|:.|   |..:.|....|:|||||.|
Mouse  2672 DSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQFRAVGPAQAHRRCPFCRALFKAKTALE 2736

  Fly   348 --MKWRHTRENLKSGQEKQPSA--------VPESGGVF--------KTSTPSGDGTPQEAL---- 390
              ::.||..|..::|.....||        :...|.:|        ..|:..|.|.|...:
Mouse  2737 AHIRSRHWHEAKRAGYNLTLSAMLLDCDGGLQMKGDIFDGTSFSHLPPSSSDGQGVPLSPVSKTM 2801

  Fly   391 -------------------DYSSDSCSSVDLS---EQADEDDNIEIN 415
                               |:.|.|.|||:|:   .:.|.||...:|
Mouse  2802 ELSPRTLLSPSSIKVEGIEDFESPSMSSVNLNFDQTKLDNDDCSSVN 2848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	16/91 (18%)
Zfhx3	NP_031522.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..79
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..129
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	417..557
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	590..621
		C2H2 Zn finger	674..694	CDD:275368
		C2H2 Zn finger	729..746	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1125..1228
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1320..1361
		C2H2 Zn finger	1375..1395	CDD:275368
		C2H2 Zn finger	1413..1433	CDD:275371
		C2H2 Zn finger	1441..1462	CDD:275371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1500..1539
		C2H2 Zn finger	1557..1581	CDD:275368
		C2H2 Zn finger	1608..1626	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1639..1678
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1706..1738
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1866..1943
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2037..2089
		HOX	2152..2208	CDD:197696
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2211..2249
		Homeobox	2252..2306	CDD:365835
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2383..2405		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2429..2529		16/109 (15%)
		COG5576	2603..2747	CDD:227863	33/168 (20%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q15911	2624..2626		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2628..2656		9/41 (22%)
		Homeobox	2654..2707	CDD:365835	17/59 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2780..2805		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2850..2877
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2920..2955
		Homeobox	2958..3011	CDD:365835
		Herpes_BLLF1	<3112..>3191	CDD:282904
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3145..3274
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3412..3473
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3585..3723
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910