DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H2.0 and CDX4

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_005184.1	Gene:	CDX4 / 1046	HGNCID:	1808	Length:	284	Species:	Homo sapiens

Alignment Length:	210	Identity:	55/210 - (26%)
Similarity:	81/210 - (38%)	Gaps:	74/210 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 HKPP-------PHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQLLDIAPTSPAA------- 263
            :.||       |..|:|...:  |::.:||                        ||||
Human    76 YSPPREDWSVYPGPSSTMGTV--PVNDVTS------------------------SPAAFCSTDYS 114

  Fly   264 ----AAAATSQNGAHGHGGGN----GQGNASAGSNGKRKRS---WS----------------RAV 301
                ....||.:...|..||:    ..|.|.|.|..:.:.|   |.                |.|
Human   115 NLGPVGGGTSGSSLPGQAGGSLVPTDAGAAKASSPSRSRHSPYAWMRKTVQVTGKTRTKEKYRVV 179

  Fly   302 FSNLQRKGLEIQFQQQKYITKPDRRKLAARLNLTDAQVKVWFQNRRMKWRHTRENLKSGQEKQPS 366
            :::.||..||.:|...:|||...:.:||..|.|::.|||:||||||.|   .|:.:|    |:.|
Human   180 YTDHQRLELEKEFHCNRYITIQRKSELAVNLGLSERQVKIWFQNRRAK---ERKMIK----KKIS 237

  Fly   367 AVPESGGVFKTSTPS 381
            ....|||..::.:.|
Human   238 QFENSGGSVQSDSDS 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	24/68 (35%)
CDX4	NP_005184.1	Caudal_act	13..162	CDD:309740	23/111 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..155		9/34 (26%)
		Homeobox	177..229	CDD:306543	24/54 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..259		4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910