DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment H2.0 and zfhx3

DIOPT Version :9

Sequence 1:	NP_523488.2	Gene:	H2.0 / 33841	FlyBaseID:	FBgn0001170	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	XP_002937624.2	Gene:	zfhx3 / 100495855	XenbaseID:	XB-GENE-853731	Length:	3619	Species:	Xenopus tropicalis

Alignment Length:	516	Identity:	115/516 - (22%)
Similarity:	160/516 - (31%)	Gaps:	198/516 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PTKESCA--------STTIVSTSPTSAT----STTKVKLSFSVDRLLGSEPEESH---------- 88
            |:..:|:        ||.:.|:|.||.|    .||..:     |.:|.|:.|.||
Frog  2354 PSSSTCSTPMTFPSFSTAVSSSSNTSCTPFLQHTTDAE-----DIILSSKSEASHDDKPKHFEPI 2413

  Fly    89 --------------RQSSSSP-STKSCCDGSILACCSFPHCFSQANAESRRF----------GHA 128
                          :|.|..| ||:|             |......||.:..          ..:
Frog  2414 RTQQNQTQEQPQQPKQESQQPQSTQS-------------HPLQHDQAEDKMSVTPQKNAPLPSSS 2465

  Fly   129 TLPP--TFTPTSSHTYPFVGLDKLFPGPYMDYKSVLRPTPIRAAEHAAPTYPTLATNALLRFHQH 191
            ..||  |.|.||.:|...         .....|.:...:|.:.|....|..|.......|.|...
Frog  2466 AQPPQCTVTQTSPNTTQI---------SQFSIKPLHTSSPQQLANIPPPLLPYQCDQCKLAFPSF 2521

  Fly   192 QK-QQHQQHH----HHQH-HPKHLHQQHKPP-----PHNSTTASALLA------PLHSLTSLQLT 239
            :. |:|||.|    .:|. ||:.|.:....|     |.|...||.||:      |..|.||
Frog  2522 EHWQEHQQLHFLSAQNQFIHPQFLDRSMDMPFMLFDPSNPLLASQLLSGGLSQIPPGSATS---- 2582

  Fly   240 QQQQRFLGKTPQQLLDIAPTSPAAAAAATSQNGAHGHGGGNGQGNASAGSNGKRKRSWSRAVFSN 304
                   ..||...::.........|.|:......|.||...|       ..||.|       :.
Frog  2583 -------PSTPSSTMNTLKRKLEEKANASPGENDSGTGGEEPQ-------RDKRLR-------TT 2626

  Fly   305 LQRKGLEIQFQQQKYITKPDRRKL---AARLNLTDAQVKVWFQNRR------------------- 347
            :..:.|||.:|:....:.|.|:.|   |..:.|....|:|||||.|
Frog  2627 ITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQFRAVGPAQAHRR 2691

  Fly   348 -----------------MKWRHTRENLKSGQEKQPSA-------VPESGGVFK----TSTP--SG 382
                             ::.||..|..::|.....||       :...|..|.    .|.|  ||
Frog  2692 CPFCRALFKAKTALEAHIRSRHWHEAKRAGYNMNLSAMLIDCDGIQLKGDFFDNTGFNSLPHSSG 2756

  Fly   383 DG--------------TPQEAL-----------DYSSDSCSSVDLS---EQADEDDNIEIN 415
            ||              :|:..|           |:.|.|.|||:||   .:.|.||...:|
Frog  2757 DGQCISFSPGSKSMELSPRTLLSPSSIKVEGVEDFESPSMSSVNLSFDQTKLDNDDCSSVN 2817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H2.0	NP_523488.2	Homeobox	298..351	CDD:278475	16/91 (18%)
zfhx3	XP_002937624.2	C2H2 Zn finger	663..683	CDD:275368
		C2H2 Zn finger	718..735	CDD:275368
		C2H2 Zn finger	1365..1385	CDD:275368
		C2H2 Zn finger	1403..1423	CDD:275371
		C2H2 Zn finger	1431..1452	CDD:275371
		C2H2 Zn finger	1547..1569	CDD:275368
		C2H2 Zn finger	1598..1616	CDD:275368
		HOX	2122..2178	CDD:197696
		Homeobox	2222..2276	CDD:365835
		COG5576	2590..2717	CDD:227863	27/140 (19%)
		Homeobox	2624..2677	CDD:365835	17/59 (29%)
		Homeobox	2926..2979	CDD:365835
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910