DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG9098 and BCAR3

DIOPT Version :9

Sequence 1:NP_608979.2 Gene:CG9098 / 33840 FlyBaseID:FBgn0031762 Length:944 Species:Drosophila melanogaster
Sequence 2:NP_001248337.1 Gene:BCAR3 / 8412 HGNCID:973 Length:825 Species:Homo sapiens


Alignment Length:780 Identity:246/780 - (31%)
Similarity:344/780 - (44%) Gaps:161/780 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   220 LKKALEWELSLDARELRSHAWYHGALPRQRAEEIVQREGDFLVRDCASQPDNYVLSCRSKAAVLH 284
            |||.||.||.|.:.:|||||||||.:|||.:|.:|||:|||||||..|.|.|:||:|:.|....|
Human   134 LKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQH 198

  Fly   285 FVLNKLVLQPETVYERVQYQFEEDAFDTVPDLITFYVGSGKPISSASGALIQFPCNRTYPLSFYG 349
            |.:|:.||:....|.|||||||.::||::|.|:..|||:.:|||..|||:|..|.|||.||    
Human   199 FKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPL---- 259

  Fly   350 HKIVGNQLHTQMLAGLRGLSPLNSPMGSNGAVGAGMNATFRFEPQQQQQQQLSPMAGSPASPHCS 414
                      :.|....|.||..:..||          ..:..|...::..|: |.|        
Human   260 ----------RCLEEHYGTSPGQAREGS----------LTKGRPDVAKRLSLT-MGG-------- 295

  Fly   415 PPRARREVPPPPRLPCKKQQRSQSLTPAQAMLVSNINKLQEQQLQMQELENGNGNGIMRFQTIAR 479
                             .|.|.|:|  .:..|:.|..|...|...:..:::.....:...|    
Human   296 -----------------VQAREQNL--PRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQ---- 337

  Fly   480 CNPTSEQHLE--SKFTTHS-----LPRPN-----TSAAHALRQQAVARISSLARNCSLDSPSDSR 532
                ||.:|.  .|....|     .|.||     |.:..||....|.|:||.||.......|||:
Human   338 ----SESYLPIGCKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQ 398

  Fly   533 -PPSPPPKPRKEPMAAVLAYQASGSDSGNGSGDSALGDACEASVQRGVIIKNPRFMTTSVSNGTL 596
             .|.|||||.|.|...|.:..::..:|.        .:.||.         ||.|.|.......|
Human   399 LCPKPPPKPCKVPFLKVPSSPSAWLNSE--------ANYCEL---------NPAFATGCGRGAKL 446

  Fly   597 KSFTEFDVLAAEEELFTMAIEEV----------------------------KTASKFDFENFVTL 633
            .|..:    .:..||.|....|.                            ....::|...|||.
Human   447 PSCAQ----GSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTP 507

  Fly   634 LLPSV---------------ENKPLDGDALNTFKMMLLETGPKLLAEHITRID--IALFLEEPSN 681
            ||.:|               |||||:...|...|.:.....||::|:|:..:|  :|..|.....
Human   508 LLETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEE 572

  Fly   682 EEDYYLSCSGLELLTLPHGKVFREDIIERTQCIKLMVAVTILTCQTDL-DRAQLLSKWIQIAVET 745
            ........|||||:|||||...|.|||||...:.:.:||.||.|...| |||..|||.||:|||.
Human   573 MRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVEL 637

  Fly   746 KTALGNLFGFCAIMLGLCMQQIQKLDQAWHILRQQYTDSAFTFEAKLRPTLSIMNEA--SNPQAP 808
            |.::|:|:.|.|:|..|.|.||.:|::.|..||.|||.:|..:|.:|:|...:::|.  |....|
Human   638 KDSMGDLYSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPP 702

  Fly   809 -NTTVPHVLLYALLIDRPVMDIINHSNIDDRPALYHTCIAPWESKADDFGMTINFQHLDASRGFL 872
             |.:||.::....|::|   ..:.....|           .||.  :|....|...||..:|...
Human   703 NNVSVPLLMPLVTLMER---QAVTFEGTD-----------MWEK--NDQSCEIMLNHLATARFMA 751

  Fly   873 KNLELYRKNAKIILEDASPRLDELLADAFRTEFHVKFLWGSSGATAKAEDRHNKLEKVLTLMADK 937
            :..:.||.||:.||....|  ||.:.:..:|||.::.||||.||.....:|:.|..::||.::.|
Human   752 EAADSYRMNAERILAGFQP--DEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRK 814

  Fly   938  937
            Human   815  814

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9098NP_608979.2 SAM_1 43..102 CDD:278937
SAM 47..103 CDD:197735
SH2_BCAR3 233..367 CDD:198200 64/133 (48%)
RasGEF 660..>797 CDD:295324 61/139 (44%)
BCAR3NP_001248337.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 40..106
SH2_BCAR3 147..282 CDD:198200 69/158 (44%)
RasGEF 544..819 CDD:214539 100/289 (35%)
Mediates the interaction with BCAR1/p130CAS. /evidence=ECO:0000305|PubMed:22081014 744..748 1/3 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165160019
Domainoid 1 1.000 103 1.000 Domainoid score I6801
eggNOG 1 0.900 - - E1_28HJ9
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 318 1.000 Inparanoid score I2546
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49555
OrthoDB 1 1.010 - - D138275at2759
OrthoFinder 1 1.000 - - FOG0003062
OrthoInspector 1 1.000 - - otm40271
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR14247
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2423
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.870

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