DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9098 and sh2d3cb

DIOPT Version :9

Sequence 1:	NP_608979.2	Gene:	CG9098 / 33840	FlyBaseID:	FBgn0031762	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_957370.1	Gene:	sh2d3cb / 394051	ZFINID:	ZDB-GENE-040426-1052	Length:	635	Species:	Danio rerio

Alignment Length:	767	Identity:	228/767 - (29%)
Similarity:	346/767 - (45%)	Gaps:	194/767 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 TAQP-SPSEQQEAIALKKALEWELSLDARELRSHAWYHGALPRQRAEEIVQREGDFLVRDCASQP 269
            |.|| ||.::     ||:.||.||.|.:..|.||.||||.:|.:.:|.:||:|||||:||..|..
Zfish    20 THQPSSPPDK-----LKQELEKELKLSSCNLSSHGWYHGRIPWEVSESLVQQEGDFLIRDSLSSI 79

  Fly   270 DNYVLSCRSKAAVLHFVLNKLVLQPETVYERVQYQFEEDAFDTVPDLITFYVGSGKPISSASGAL 334
            .:|||:||.....|||::.|::|:....|.||||..||:.|.:||.|:..|||:.:|::..|.|.
Zfish    80 GDYVLTCRWNQKALHFLITKVLLRSYDTYTRVQYILEEETFYSVPALVHSYVGNKRPLTKKSAAY 144

  Fly   335 IQFPCNRTYPLSF----YGHKIVGNQLHTQMLAGLRGLSPLNSPMGSNGAVGAGMNATFRFEPQQ 395
            |..|.|||.||.:    :|...|.|.|             :|||....|:
Zfish   145 IYSPVNRTLPLRYLETMFGLPSVENSL-------------VNSPSTQKGS--------------- 181

  Fly   396 QQQQQLSPMAGSPASPHCSPPRARREVPPPPRLPCKKQQRSQSLTPAQAMLVSNINKLQEQQLQM 460
                                                 |::.:|:...:|:
Zfish   182 -------------------------------------QKKRESIAVTEAL--------------- 194

  Fly   461 QELENGNGNGIMRFQT--IARCNPTSEQHLESKFTTHSLPRPNTSAAHALRQQAVARISSLARNC 523
             |:|      ::|.||  :...:.|.|||:.            .|.:..|       :|:|||.
Zfish   195 -EIE------LIRPQTDVVRSFDGTVEQHVV------------VSTSPIL-------MSTLARR- 232

  Fly   524 SLDSPSDSR-----PPSPPPKPRKEPMAAVLAYQASGSDSGNGSGDSALGDACEASVQRGVIIKN 583
             ..|||.:|     |.||..|                      |.::.|   |.:..:..:|...
Zfish   233 -RRSPSGNRKFVIIPSSPVLK----------------------SNETRL---CSSPPENTLIYLE 271

  Fly   584 PR---FMTTSVSNGTLKSFTE-FDVLAAEEELFTMAIEEVKTASKFDFE-------NFVTLLLPS 637
            |.   ..:.:..|.|..|::. .|.||.......:.|:.|....::|.:       :.|:...||
Zfish   272 PTVHLLSSMTYQNSTKSSYSHTTDPLATNHPFVELEIQAVDRREEYDEDYLVPFTTDMVSCFRPS 336

  Fly   638 V--------ENKPLDGDALNTFKMMLLETGPKLLAEHITRID--IALFLEEPSNEEDYYLSCSGL 692
            :        |||||:...|...|.:|.|...|.:|.|||:||  :|..|:...:........||:
Zfish   337 MYQSPFMPPENKPLETRILKRVKDVLFEVDIKTMATHITKIDCMVARILDMSEDVMKGMGVSSGM 401

  Fly   693 ELLTLPHGKVFREDIIERTQCIKLMVAVTILTCQTDLD-RAQLLSKWIQIAVETKTALGNLFGFC 756
            ||||||||...|:|::||...:.:|.||.:|.|..:.| ||.||.:.|.:|.|.|::|||||||.
Zfish   402 ELLTLPHGHHLRQDLLERFHTMSIMWAVQLLGCTGNADERADLLHRAICLASELKSSLGNLFGFA 466

  Fly   757 AIMLGLCMQQIQKLDQAWHILRQQYTDSAFTFEAKLRPTLSIMNEA-SNPQAPNTTVPHVLLYAL 820
            .:|..|.:.||.:|:::|.|:||:||:||..:|..|||:|.:|||. :..:...||.||||....
Zfish   467 TVMKCLELPQIARLNESWTIVRQKYTESAILYEKTLRPSLRMMNEGEAISRHTETTFPHVLPLLS 531

  Fly   821 LIDRPVMDIINHSNIDDRPALYHTCIAPWESKADDFGMTINFQHLDASRGFLKNLELYRKNAKII 885
            |.:|.|.:                 :..|||.  |.|:.:...||||:|....|..::..||:..
Zfish   532 LFERTVEE-----------------LESWESA--DTGVALVLSHLDAARTIALNGRIFSANAEAK 577

  Fly   886 LEDASPRLDELLADAFRTEFHVKFLWGSSGATAKAEDRHNKLEKVLTLMADK 937
            |:......|  :.:.|.|||.::.||||.|.....::|::|.::|||.::::
Zfish   578 LQGFEEEAD--VREIFLTEFQMRLLWGSRGVERNKDERYSKFDEVLTALSNR 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9098	NP_608979.2	SAM_1	43..102	CDD:278937
		SAM	47..103	CDD:197735
		SH2_BCAR3	233..367	CDD:198200	57/137 (42%)
		RasGEF	660..>797	CDD:295324	61/139 (44%)
sh2d3cb	NP_957370.1	SH2_BCAR3	43..178	CDD:198200	60/147 (41%)
sh2d3cb	NP_957370.1	RasGEF	365..>533	CDD:295324	71/167 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596313
Domainoid	1	1.000	119	1.000	Domainoid score	I5756
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H138112
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2613
OMA	1	1.010	-	-		QHG49555
OrthoDB	1	1.010	-	-		D138275at2759
OrthoFinder	1	1.000	-	-		FOG0003062
OrthoInspector	1	1.000	-	-		otm25757
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2423
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.010