DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9098 and Bcar3

DIOPT Version :9

Sequence 1:	NP_608979.2	Gene:	CG9098 / 33840	FlyBaseID:	FBgn0031762	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_001101192.1	Gene:	Bcar3 / 310838	RGDID:	1311688	Length:	825	Species:	Rattus norvegicus

Alignment Length:	852	Identity:	264/852 - (30%)
Similarity:	375/852 - (44%)	Gaps:	179/852 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 PRSK--------CNS-------PHWAIEDSRMEGYGSSNATTPLATAQPSPSEQQEAIA------ 219
            ||.|        |:|       ||  .:..|.    ||..|..|...:|.|..:.::.|
  Rat    52 PRKKKGPPPIRSCDSASHMGTLPH--SKSPRQ----SSPLTQDLILEKPLPDWKGDSFAFRDPYL 110

  Fly   220 -----------------------LKKALEWELSLDARELRSHAWYHGALPRQRAEEIVQREGDFL 261
                                   |||.||.||.|.:.:|||||||||.:|||.:|.:|||:||||
  Rat   111 LDPTLEYVKFSKERHIMDRTPERLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFL 175

  Fly   262 VRDCASQPDNYVLSCRSKAAVLHFVLNKLVLQPETVYERVQYQFEEDAFDTVPDLITFYVGSGKP 326
            |||..|.|.|:||:|:.|....||.:|:.||:....|.|||||||.::||::|.|:..|||:.:|
  Rat   176 VRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP 240

  Fly   327 ISSASGALIQFPCNRTYPLSFYGHKIVGNQLHTQMLAGLRGLSPLNSPMGSNGAVGAGMNATFRF 391
            ||..|||:|..|.|||.||              ..|....|.||           |.|...:|.
  Rat   241 ISQQSGAIIFQPINRTVPL--------------WCLEERYGTSP-----------GRGREGSFA- 279

  Fly   392 EPQQQQQQQLSPMAGSPASPHCSPPRARREVPPPPRLPCKKQQRSQSLTPAQAMLVSNINKLQEQ 456
            |.:....::||...|...:...|.||..                          |:.|.:|...|
  Rat   280 EGRPDVVKRLSLTTGGIQARDHSLPRGN--------------------------LLRNKDKSGSQ 318

  Fly   457 QLQMQELENGNGNGIMRFQTIARCNPTSEQHL-------ESKFTTHSLPRPN-----TSAAHALR 509
            ...:..:::.....:...|        ||.||       ....:..:.|.||     |.:...|.
  Rat   319 PACLDHVQDRKAATLKAHQ--------SESHLPIGCKLPPQSPSVDTSPCPNSPVFRTGSEPTLS 375

  Fly   510 QQAVARISSLARNCSLDSPSDSR-PPSPPPKPRKEPMAAV-------LAYQAS----------GS 556
            ...|.|.||.||.......|||: .|.|||||.|.|...|       |..:|:          |.
  Rat   376 PALVRRFSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPPSPSPWLNSEANYCELNPAFAVGC 440

  Fly   557 DSGNGSGDSALGDACE---ASVQRGVIIKNPR--FMTTSVSNGTLKSFTEFDVLAA-------EE 609
            |.|......|| |:.|   .:.|.|.  ..||  .:..|:.:|..:. ..:|.||.       :|
  Rat   441 DRGAKLLSQAL-DSHEMLLTAKQNGA--SGPRNSGINYSILDGDDQG-RHWDPLAVQTDEGQEDE 501

  Fly   610 ELFTMAIEEVKTASKFDFENFVTLLLPSVENKPLDGDALNTFKMMLLETGPKLLAEHITRID--I 672
            ..|...:.|  |.|.|...:|.:.|||. |||||:...|...|.:......:::|:|:..:|  :
  Rat   502 TKFVPPVME--TVSSFRPNDFESKLLPP-ENKPLETAMLKHAKELFTNHDARVIAQHMLSVDCKV 563

  Fly   673 ALFLEEPSNEEDYYLSCSGLELLTLPHGKVFREDIIERTQCIKLMVAVTILTCQTDLD-RAQLLS 736
            |..||...:.:......|||||:|||||:..|.|||||...:.:.:||.||.|...|: ||..|:
  Rat   564 ARILEVSEDMKRSMGVSSGLELITLPHGRQLRLDIIERHNTMAIGIAVDILGCTGTLENRAGTLN 628

  Fly   737 KWIQIAVETKTALGNLFGFCAIMLGLCMQQIQKLDQAWHILRQQYTDSAFTFEAKLRPTLSIMNE 801
            |.||:|:|.|..:|:|:.|.|||..|.|.||.:|::.|..||..||.:|..:|.:|:|...|::|
  Rat   629 KIIQVAMELKDTMGDLYSFSAIMKALEMPQITRLEKTWTALRHHYTQTAILYEKQLKPFSKILHE 693

  Fly   802 A-SNPQAPNTTVPHVLLYALLIDRPVMDIINHSNIDDRPALYHTCIAPWESKADDFGMTINFQHL 865
            . .:...|.::|...||..|:            .:.:|.|:.......||.  :|....|...||
  Rat   694 GRESTYVPASSVSVPLLMPLV------------TLMERQAVTFEGTDMWEK--NDESCEIMLSHL 744

  Fly   866 DASRGFLKNLELYRKNAKIILEDASPRLDELLADAFRTEFHVKFLWGSSGATAKAEDRHNKLEKV 930
            ..:|...:..|.||.||:.:|.|..|  ||.:.:..:|||.::.||||.||.....:|::|..::
  Rat   745 ATARFMAEASESYRMNAERVLADFQP--DEEMTEILKTEFQMRLLWGSKGAEVNQNERYDKFNQI 807

  Fly   931 LTLMADK 937
            ||.::.|
  Rat   808 LTALSRK 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9098	NP_608979.2	SAM_1	43..102	CDD:278937
		SAM	47..103	CDD:197735
		SH2_BCAR3	233..367	CDD:198200	64/133 (48%)
		RasGEF	660..>797	CDD:295324	57/139 (41%)
Bcar3	NP_001101192.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..84		9/37 (24%)
		SH2_BCAR3	148..282	CDD:198200	71/159 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..320		7/45 (16%)
		RasGEF	544..819	CDD:413337	97/287 (34%)
		Mediates the interaction with BCAR1/p130CAS. /evidence=ECO:0000250\|UniProtKB:O75815	744..748		1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354089
Domainoid	1	1.000	102	1.000	Domainoid score	I6681
eggNOG	1	0.900	-	-		E1_28HJ9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	302	1.000	Inparanoid score	I2591
OMA	1	1.010	-	-		QHG49555
OrthoDB	1	1.010	-	-		D138275at2759
OrthoFinder	1	1.000	-	-		FOG0003062
OrthoInspector	1	1.000	-	-		otm44396
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14247
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2423
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.870