DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9098 and Bcar3

DIOPT Version :9

Sequence 1:	NP_608979.2	Gene:	CG9098 / 33840	FlyBaseID:	FBgn0031762	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_038895.1	Gene:	Bcar3 / 29815	MGIID:	1352501	Length:	820	Species:	Mus musculus

Alignment Length:	771	Identity:	246/771 - (31%)
Similarity:	354/771 - (45%)	Gaps:	142/771 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 LKKALEWELSLDARELRSHAWYHGALPRQRAEEIVQREGDFLVRDCASQPDNYVLSCRSKAAVLH 284
            |||.||.||.|.:.:|||||||||.:|||.:|.:|||:|||||||..|.|.|:||:|:.|....|
Mouse   128 LKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQH 192

  Fly   285 FVLNKLVLQPETVYERVQYQFEEDAFDTVPDLITFYVGSGKPISSASGALIQFPCNRTYPLSFYG 349
            |.:|:.||:....|.|||||||.::||::|.|:..|||:.:|||..|||:|..|.|||.||
Mouse   193 FKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPL---- 253

  Fly   350 HKIVGNQLHTQMLAGLRGLSPLNSPMGSNGAVGAGMNATFRFEPQQQQQQQLSPMAGSPASPHCS 414
                      ..|....|.||   ..|..|::..|         :....::||...||..
Mouse   254 ----------WCLEERYGTSP---GRGREGSLAEG---------RPDVVKRLSLTTGSSI----- 291

  Fly   415 PPRARREVPPPPRLPCKKQQRSQSLTPAQAMLVSNINKLQEQQLQMQELENGNGNGIMRFQTIAR 479
                              |.|..||  .:..|:.|..|...|...:..:::.....:...|
Mouse   292 ------------------QAREHSL--PRGNLLRNKEKSGSQPACLDHVQDRKALTLKAHQ---- 332

  Fly   480 CNPTSEQHLE--SKFTTHS-----LPRPN-----TSAAHALRQQAVARISSLARNCSLDSPSDSR 532
                ||.||.  .|....|     .|.|:     |.:...|....|.|.||.||.......|||:
Mouse   333 ----SESHLPIGCKLPPQSPSMDTSPCPSSPVFRTGSEPTLSPALVRRFSSDARTGEALRGSDSQ 393

  Fly   533 -PPSPPPKPRKEPMAAV-------LAYQASGSDSGNGSGDSALGDACEASVQRGVIIKNP----- 584
             .|.|||||.|.|....       |..:|:..:         |..|......||.  |.|
Mouse   394 LCPKPPPKPCKVPFLKTPPSPSPWLTSEANYCE---------LNPAFAVGCDRGA--KLPMQAHD 447

  Fly   585 --RFMTTSVSN---GTLKSFTEFDVLAAEEEL-----FTMAIEE------------VKTASKFDF 627
              ..:.|:..|   |...|...:.:|..:::.     ..:..:|            ::|.|.|..
Mouse   448 SHEMLLTAKQNGPSGPRNSGINYMILDGDDQARHWDPLAVQTDEGQEDKTKFVPPLMETVSSFRP 512

  Fly   628 ENFVTLLLPSVENKPLDGDALNTFKMMLLETGPKLLAEHITRID--IALFLEEPSNEEDYYLSCS 690
            .:|.:.|||. |||||:...|...|.:......:::|:|:..:|  :|..||...:.:......|
Mouse   513 NDFESKLLPP-ENKPLETAMLKHAKELFTNHDARVIAQHMLSVDCKVARILEVSEDRKRSMGVSS 576

  Fly   691 GLELLTLPHGKVFREDIIERTQCIKLMVAVTILTCQTDLD-RAQLLSKWIQIAVETKTALGNLFG 754
            ||||:|||||:..|.|||||...:.:.:||.||.|...|: ||..|:|.||:|||.|.|:|:|:.
Mouse   577 GLELITLPHGRQLRLDIIERHNTMAIGIAVDILGCTGTLENRAGTLNKIIQVAVELKDAMGDLYA 641

  Fly   755 FCAIMLGLCMQQIQKLDQAWHILRQQYTDSAFTFEAKLRPTLSIMN---EASNPQAPNTTVPHVL 816
            |.|||..|.|.||.:|::.|..||..||.:|..:|.:|:|...|::   |::...|.|.:||.::
Mouse   642 FSAIMKALEMPQITRLEKTWTALRHHYTQTAILYEKQLKPFSKILHEGRESTYVPASNVSVPLLM 706

  Fly   817 LYALLIDRPVMDIINHSNIDDRPALYHTCIAPWESKADDFGMTINFQHLDASRGFLKNLELYRKN 881
            ....|::|   ..:.....|           .||:..:...:.:|  ||..:|...:..|.||.|
Mouse   707 PLVTLMER---QAVTFEGTD-----------MWENNDESCEILLN--HLATARFMAEASESYRMN 755

  Fly   882 AKIILEDASPRLDELLADAFRTEFHVKFLWGSSGATAKAEDRHNKLEKVLTLMADK 937
            |:.||.|..|  ||.:.:..||||.::.||||.||.....:|::|..::||.::.|
Mouse   756 AERILADFQP--DEEMTEILRTEFQMRLLWGSKGAEVNQNERYDKFNQILTALSRK 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9098	NP_608979.2	SAM_1	43..102	CDD:278937
		SAM	47..103	CDD:197735
		SH2_BCAR3	233..367	CDD:198200	64/133 (48%)
		RasGEF	660..>797	CDD:295324	59/139 (42%)
Bcar3	NP_038895.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..81
		SH2_BCAR3	142..276	CDD:198200	70/159 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..367		4/20 (20%)
		RasGEF	539..814	CDD:295324	100/289 (35%)
		Mediates the interaction with BCAR1/p130CAS. /evidence=ECO:0000250\|UniProtKB:O75815	739..743		1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850390
Domainoid	1	1.000	99	1.000	Domainoid score	I7074
eggNOG	1	0.900	-	-		E1_28HJ9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I2640
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49555
OrthoDB	1	1.010	-	-		D138275at2759
OrthoFinder	1	1.000	-	-		FOG0003062
OrthoInspector	1	1.000	-	-		otm42338
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2423
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.870