Protein Alignment CG9098 and Sh2d3c

DIOPT Version :10

• Sequence 1: NP_608979.2
• Gene: CG9098 / 33840
• FlyBaseID: FBgn0031762
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: NP_038809.1
• Gene: Sh2d3c / 27387
• MGIID: 1351631
• Length: 854
• Species: Mus musculus
• Alignment Length: 879
• Identity: 266/879 - (30%)
• Similarity: 400/879 - (45%)
• Gaps: 164/879 - (18%)

  Fly   102 RAKRRQSM-NLEAMSSAPRAVPRRKNSCPLVYLGENPQDM-----AGSG------DSGPGVITTK 154
            :|:::|:: ..:.:|.....|.||        |.| |.|:     ||.|      |:.|..:...
Mouse    87 KAQKQQAVQKAQEVSRESHLVSRR--------LPE-PPDLEAAKEAGEGTEALLEDTAPSAVEVD 142

  Fly   155 SGKVLKQLTFD-ETSTIYEELRPRSKCNSPHWAIEDSRMEGYGSSNATTPLATAQPSPSEQQEAI 218
            ..:.|:.||.| |...:..::.|.      ..|.|......|...:....:..:.|.
Mouse   143 PMRELEDLTVDTEKEQVPGDVSPE------RTAAELEAAGDYVKFSKEKYILDSSPE-------- 193

  Fly   219 ALKKALEWELSLDARELRSHAWYHGALPRQRAEEIVQREGDFLVRDCASQPDNYVLSCRSKAAVL 283
            .|.|.||.||.|.:.:|||||||||.:||:.:|.:|||.||||:||..:...:|||:||.....|
Mouse   194 KLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWHNQAL 258

  Fly   284 HFVLNKLVLQPETVYERVQYQFEEDAFDTVPDLITFYVGSGKPISSASGALIQFPCNRTYPLSF- 347
            ||.:||:|::....|..::|.||:::||.||.|:.::|||.|.:|..|||:|..|.|||:||.:
Mouse   259 HFKINKVVVKAGESYTHIRYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYL 323

  Fly   348 ---YGHKIVGNQLHTQMLAGLRGLSPLNSPMGSNGAVGAGMNATFRFEPQQQQQQQLSPMAGSPA 409
               ||..              :|.|...||...:|:.|:.|.
Mouse   324 EASYGLS--------------QGSSKTASPASPSGSKGSHMK----------------------- 351

  Fly   410 SPHCSPPRARREVPPPPRLPCKKQQRSQSLTPAQAMLVSNINKLQEQQLQMQELENGNGNGIMRF 474
                     ||.:.....|...|..||.. .|....|....:.::...|.|.::.:.:
Mouse   352 ---------RRSITMTDGLTTDKVTRSDG-CPNSTSLPHPRDSIRNCALSMDQIPDLH------- 399

  Fly   475 QTIARCNPTSEQHLESKFTT----HS-LPRPNTSAAHALRQQAVARISSLARNCSLDSP-----S 529
               :..:|.||......::|    |: ...|:|||..|   ..|||.||..:.|..::|     |
Mouse   400 ---SPLSPISESPSSPAYSTVTRVHAPSATPSTSAQPA---SPVARRSSEPQLCPGNTPKPPGES 458

  Fly   530 DSRPPSPPPKP--RKEPMAAVLAYQASGSDSGN---------GSGDSALGDACEASVQRGVIIKN 583
            |..|.:.|...  :..|..::.:|  |..|||:         ||.:.|.|:....:  ||...:.
Mouse   459 DRAPHASPSHTLCKASPSPSLSSY--SDPDSGHYCQLQPPVRGSREQAAGETPRKA--RGSGERQ 519

  Fly   584 PRFMTTSVSNGTL-KSFTEFDVLAAEEELFTMAIEEVKTASKFDFENFVTLLLPSVENKPLDGDA 647
            ...:...||:|.. |:||               :..|:..|.|:...|.:.|:|. ||:||:...
Mouse   520 KELLENGVSDGEWGKTFT---------------VPVVEATSSFNLATFQSQLIPK-ENRPLEVAL 568

  Fly   648 LNTFKMMLLETGPKLLAEHITRID--IALFLEEPSNEEDYYLSCSGLELLTLPHGKVFREDIIER 710
            |...|.:|.|...:.||.|:|::|  :|..|......:.......|:||||||||:..|.|::||
Mouse   569 LRKVKELLSEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLER 633

  Fly   711 TQCIKLMVAVTILTCQTDL-DRAQLLSKWIQIAVETKTALGNLFGFCAIMLGLCMQQIQKLDQAW 774
            ...:.:|:||.||.|.... :||.||.|.||:|.|.:..:||:|.|.|:|..|.|.||.:|:|.|
Mouse   634 FHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALEMAQISRLEQTW 698

  Fly   775 HILRQQYTDSAFTFEAKLRPTLSIMNEA-SNPQAPNTTVPHVLLYALLIDRPVMDIINHSNIDDR 838
            ..|||::|:.|..:|.||:|.|..:||. ..|...|||.||||.:..|::           .|..
Mouse   699 MTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPFITLLE-----------CDSA 752

  Fly   839 PALYHTCIAPWESKADDFGMTINFQHLDASRGFLKNLELYRKNAKIILEDASPRLDELLADAFRT 903
            ||   ....||.|  .:.|:.:...||:|:|....:..||..||::.|:....| .||| :.|.|
Mouse   753 PA---EGPEPWGS--TEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQAR-PELL-EVFST 810

  Fly   904 EFHVKFLWGSSGATAKAEDRHNKLEKVLTLMADK 937
            ||.::.||||.||.:....|:.|.:||||.::.|
Mouse   811 EFQMRLLWGSQGANSSQAWRYEKFDKVLTALSHK 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9098	NP_608979.2	SAM_1	42..102	CDD:425739	266/879 (30%)
		SH2_BCAR3	233..367	CDD:198200	58/137 (42%)
		RasGEF	660..>797	CDD:470590	57/139 (41%)
Sh2d3c	NP_038809.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..129		13/50 (26%)
		SH2_BCAR3	208..342	CDD:198200	62/147 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	330..384		15/100 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..417		3/28 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	422..520		28/104 (27%)
		RasGEF	579..>756	CDD:470590	72/190 (38%)