DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9098 and LOC101731830

DIOPT Version :9

Sequence 1:	NP_608979.2	Gene:	CG9098 / 33840	FlyBaseID:	FBgn0031762	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_031750079.1	Gene:	LOC101731830 / 101731830	-ID:	-	Length:	673	Species:	Xenopus tropicalis

Alignment Length:	783	Identity:	235/783 - (30%)
Similarity:	342/783 - (43%)	Gaps:	195/783 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 AIALKKALEWELSLDARELRSHAWYHGALPRQRAEEIVQREGDFLVRDCASQPDNYVLS-CRSKA 280
            |..|||.||.||.|.:.:|||||||||.||||.||.::...||||:||..|.|.:|||| |.:..
Frog     5 ADTLKKELEEELKLSSEDLRSHAWYHGPLPRQDAERLLVSNGDFLIRDSISSPGDYVLSCCCAGG 69

  Fly   281 AVLHFVLNKLVLQPETVYERVQYQFEEDAFDTVPDLITFYVGSGKPISSASGALIQFPCNRTYPL 345
            ..|||.:..:.|:|.....|..||.|:|.||.:|.|:..|||..:.:|.::||:|..|.||:.||
Frog    70 QPLHFKIIAVALRPRRGIARTLYQLEQDQFDNIPALVRSYVGDRRKVSESTGAVIIRPVNRSLPL 134

  Fly   346 SF----YGHKIVGNQLHTQML-----AGLRGLSPLNSPMGSNGAVGAGMNATFRFEPQQQQQQ-- 399
            :.    :.....|::.|.:.|     :.||......|..|:..|:        :..|.|..|.
Frog   135 TALRERHNGPSGGDRDHRRSLILSESSLLRTKERFGSQPGNLDAL--------KERPLQSAQSDS 191

  Fly   400 --------QLSPMAGSPASPHCSP-------PRARREVPPPPRLPCKKQQRSQSLTPAQAMLVSN 449
                    :.||.|.:|.....||       |..|.:..|.|.|..
Frog   192 NLLSALTAETSPPAQTPMPAPLSPLFRTGSDPVLRAKTVPAPSLDL------------------- 237

  Fly   450 INKLQEQQLQMQELENGNGNGIMRFQTIARCNPTSEQHLESKFTTHSLPRPNTSAAHALRQQAVA 514
                             :||..:|         .|:..|.||    :.|:|             .
Frog   238 -----------------DGNSGLR---------GSDSQLHSK----APPKP-------------I 259

  Fly   515 RISSLARNCSLDSPSDS---------RPPSPPPKP------------RKEPMAAVLAY-QASGSD 557
            |..||.    |..|.|.         |.|..|.:|            |.........: ::..|.
Frog   260 RAPSLL----LSEPPDEGDTYSELVPRVPVFPKRPVDHGKAEERWKNRVRATETTFGFLESEESQ 320

  Fly   558 SGNGSGDSALGDACEASVQRGVIIKNPRFMTTSVSNGTLKSFTEFDVLAAEEELFTMAIEEVKTA 622
            .|.|||...||.|...:|           :.|:|              |||||.......::::.
Frog   321 GGVGSGTGLLGGASTVTV-----------VPTAV--------------AAEEEEDPFVRPQIQST 360

  Fly   623 SKFDFENFVTLLLPSVENKPLDGDALNTFKMMLLETGPKLLAEHITRID---IALFLEEPSNEED 684
            |.:....|.:||||. |||||:..||...|.::.:...|..|.||.|.|   |.::...|..:..
Frog   361 SSYQPSAFHSLLLPP-ENKPLEPAALRKLKEIVSQRDCKESALHILREDCKEIRIWGITPEQQRM 424

  Fly   685 YYLSCSGLELLTLPHGKVFREDIIERTQCIKLMVAVTILTCQTDL-DRAQLLSKWIQIAVETKTA 748
            ..:. |||||||||:|:..|.|::||...:.|.|||.||.|...: :||..|.:.||:|||.:..
Frog   425 MGVR-SGLELLTLPYGQQLRRDLLERHHLLCLGVAVDILGCTGAVSERAHTLHRIIQLAVELRDH 488

  Fly   749 LGNLFGFCAIMLGLCMQQIQKLDQAWHILRQQYTDSAFTFEAKLRPTLSIMNEA-SNPQAPNTTV 812
            .|:||.|.|:|..|.:.|:.:|:|.|..|:|.:|.||.||:.:|:|.|..::|. :.|.|.:..|
Frog   489 AGDLFAFSAVMKALTLPQVARLEQTWQALQQLHTQSAITFQKQLKPALRDLDECFALPPASDVVV 553

  Fly   813 PHVLLYALLIDRPVMDIINHSNIDDRPALYHTCIAPWESKADDFGMTIN------FQHLDASRGF 871
            ||::        ||:..:...                    ||.|.|:.      .:.|.|:|.:
Frog   554 PHIV--------PVLRAMEGE--------------------DDAGGTMEESCARLLRVLQAARSY 590

  Fly   872 LKNLELYRKNAKIILE--DASPRLDELLADAFRTEFHVKFLWGSSGATAKAEDRHNKLEKVLTLM 934
            ..|.||::|||:..||  .|.|.|.|    ||:|||.::..|||.|||.:.::|:.|.:::|:::
Frog   591 AANAELHQKNAENKLEGHTALPELGE----AFQTEFSLRLFWGSKGATVEQKERYRKFDQILSVL 651

  Fly   935 ADK 937
            :.|
Frog   652 SQK 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9098	NP_608979.2	SAM_1	43..102	CDD:278937
		SAM	47..103	CDD:197735
		SH2_BCAR3	233..367	CDD:198200	58/143 (41%)
		RasGEF	660..>797	CDD:295324	57/140 (41%)
LOC101731830	XP_031750079.1	SH2_BCAR3	22..146	CDD:198200	54/123 (44%)
LOC101731830	XP_031750079.1	RasGEF	396..591	CDD:413337	73/223 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9157
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138275at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47444
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010