DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9098 and sh2d3c

DIOPT Version :9

Sequence 1:	NP_608979.2	Gene:	CG9098 / 33840	FlyBaseID:	FBgn0031762	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_002935534.1	Gene:	sh2d3c / 100488781	XenbaseID:	XB-GENE-6258390	Length:	872	Species:	Xenopus tropicalis

Alignment Length:	783	Identity:	250/783 - (31%)
Similarity:	368/783 - (46%)	Gaps:	129/783 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 NSPHWAIEDSRMEGYGSSNATTPLATAQ---PSPSEQQEAIALKKALEWELSLDARELRSHAWYH 242
            |...|  ||....|..:.:.....:..:   .:|.|:     |.|.||.||.|::.:||||||||
Frog   183 NKGSW--EDGMCSGLDAGSEYVKFSKEKYILDTPPEK-----LHKELEEELKLNSSDLRSHAWYH 240

  Fly   243 GALPRQRAEEIVQREGDFLVRDCASQPDNYVLSCRSKAAVLHFVLNKLVLQPETVYERVQYQFEE 307
            |.:||:.:|.:|||.||||:||..:...:|||:||.|...|||.:||::::....|.|:||.||:
Frog   241 GRIPREVSESLVQRNGDFLIRDSLTSLGDYVLTCRWKNEPLHFKINKVMVKTSDSYTRIQYLFEQ 305

  Fly   308 DAFDTVPDLITFYVGSGKPISSASGALIQFPCNRTYPLSFYGHKIVGNQLHTQMLAGLRGLSPLN 372
            ::||.:|.|:.|||||.:.:|..|.|||..|.||||||.:              |....||||
Frog   306 ESFDNIPALVRFYVGSRRSVSEQSSALIYCPINRTYPLRY--------------LEASYGLSP-- 354

  Fly   373 SPMGSNGAVGAGMNATFRFEPQQQQQQQLSPMAGSPASPHCSPPRARREVPPPPRLPCKKQQRSQ 437
               |..|.                        |.||...|..    ||.:.....|...|..:|.
Frog   355 ---GRQGG------------------------ARSPQKGHMK----RRSITMTDGLTADKINKSN 388

  Fly   438 ------SLTPAQAMLVSN----INKLQEQQLQMQELENGNGNGIMRFQTIARCNPTSEQHLESKF 492
                  |.:|....::.|    ::::|:....|..:....|:  ..:.|:.|..|
Frog   389 GCPNSGSSSPHHRDMIRNCAVSVDQIQDLHSPMSPISETPGS--PAYSTVVRVKP---------- 441

  Fly   493 TTHSLPRPN-TSAAHALRQQAVARISSLARNCSLDSPSDSRPPSPPPKPRK-EPMAAVLAYQASG 555
                 |... |..:..||:.:...:.. |.|.:..:.:||...||....|. .|..::.:|
Frog   442 -----PLSGATPGSPVLRRSSEPYVCP-ANNKAALNMADSHHSSPSHTHRNISPSPSINSY---- 496

  Fly   556 SDSGNG-----SGDSALGDACEASVQRGVIIKNPRFMTTSVSNGTLKSFTEFDVLAAEEELFTMA 615
            ||..||     ...|...||...|:.....::..|....:::.| ::...:.|   .:...|.:.
Frog   497 SDPDNGHYCQLRPASPTHDALSVSLPPKSYVERLRVDECAMAGG-MRGVDDVD---RDPGCFIVP 557

  Fly   616 IEEVKTASKFDFENFVTLLLPSVENKPLDGDALNTFKMMLLETGPKLLAEHITRID--IALFLEE 678
            ..|.|  |.|:..||.:.|:|| :||||:...|...|.:..|...|.:|:|||:.|  :|..|..
Frog   558 TMEAK--SSFNPSNFKSTLIPS-DNKPLEMSILKKVKELFAEVDAKTIAKHITKTDCEVARILCV 619

  Fly   679 PSNEEDYYLSCSGLELLTLPHGKVFREDIIERTQCIKLMVAVTILTC--QTDLDRAQLLSKWIQI 741
            ....:......||:||||||||...|.|::||...:.:|:||.||.|  .|: :||.||.|.||:
Frog   620 TKEMQRIMGVSSGMELLTLPHGHQLRLDLLERFHTMSIMIAVDILGCTGSTE-ERAALLHKTIQL 683

  Fly   742 AVETKTALGNLFGFCAIMLGLCMQQIQKLDQAWHILRQQYTDSAFTFEAKLRPTLSIMNEA--SN 804
            |.|.|..:||:|.|.|:|..|.|.||.:|:|.|..|||::|:.|..:|.||:|.|..|||.  |.
Frog   684 AAELKGTMGNMFSFAAVMNALEMSQISRLEQTWVALRQRHTEGAILYEKKLKPFLKSMNEGKESL 748

  Fly   805 PQAPNTTVPHVLLYALLIDRPVMDIINHSNIDDRPALYHTCIAPWESKADDFGMTINFQHLDASR 869
            |.: |||.||::....|::|            |.|.|...  .||:|  .|.|:.:...||:|:|
Frog   749 PLS-NTTFPHIIPLITLLER------------DNPLLDGG--DPWDS--SDNGVEVVMAHLEAAR 796

  Fly   870 GFLKNLELYRKNAKIILEDASPRLDELLADAFRTEFHVKFLWGSSGATAKAEDRHNKLEKVLTLM 934
            ....:..||..||::.|:...||.|  |.:...|||.::.||||.||.....:|:||.:|||..:
Frog   797 MVAHHGGLYHTNAEMRLQGFHPRSD--LLEVSSTEFQMRMLWGSRGALGSQVERYNKFDKVLAAL 859

  Fly   935 ADK 937
            :.|
Frog   860 SHK 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9098	NP_608979.2	SAM_1	43..102	CDD:278937
		SAM	47..103	CDD:197735
		SH2_BCAR3	233..367	CDD:198200	60/133 (45%)
		RasGEF	660..>797	CDD:295324	61/140 (44%)
sh2d3c	XP_002935534.1	SH2_BCAR3	231..366	CDD:198200	69/177 (39%)
sh2d3c	XP_002935534.1	RasGEF	597..865	CDD:382986	111/286 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	112	1.000	Domainoid score	I6144
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2590
OMA	1	1.010	-	-		QHG49555
OrthoDB	1	1.010	-	-		D138275at2759
OrthoFinder	1	1.000	-	-		FOG0003062
OrthoInspector	1	1.000	-	-		otm47444
Panther	1	1.100	-	-	O	PTHR14247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2423
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080