Protein Alignment CG9098 and sh2d3c

DIOPT Version :10

• Sequence 1: NP_608979.2
• Gene: CG9098 / 33840
• FlyBaseID: FBgn0031762
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: XP_002935534.1
• Gene: sh2d3c / 100488781
• XenbaseID: XB-GENE-6258390
• Length: 872
• Species: Xenopus tropicalis
• Alignment Length: 783
• Identity: 250/783 - (31%)
• Similarity: 368/783 - (46%)
• Gaps: 129/783 - (16%)

  Fly   181 NSPHWAIEDSRMEGYGSSNATTPLATAQ---PSPSEQQEAIALKKALEWELSLDARELRSHAWYH 242
            |...|  ||....|..:.:.....:..:   .:|.|:     |.|.||.||.|::.:||||||||
 Frog   183 NKGSW--EDGMCSGLDAGSEYVKFSKEKYILDTPPEK-----LHKELEEELKLNSSDLRSHAWYH 240

  Fly   243 GALPRQRAEEIVQREGDFLVRDCASQPDNYVLSCRSKAAVLHFVLNKLVLQPETVYERVQYQFEE 307
            |.:||:.:|.:|||.||||:||..:...:|||:||.|...|||.:||::::....|.|:||.||:
 Frog   241 GRIPREVSESLVQRNGDFLIRDSLTSLGDYVLTCRWKNEPLHFKINKVMVKTSDSYTRIQYLFEQ 305

  Fly   308 DAFDTVPDLITFYVGSGKPISSASGALIQFPCNRTYPLSFYGHKIVGNQLHTQMLAGLRGLSPLN 372
            ::||.:|.|:.|||||.:.:|..|.|||..|.||||||.:              |....||||
 Frog   306 ESFDNIPALVRFYVGSRRSVSEQSSALIYCPINRTYPLRY--------------LEASYGLSP-- 354

  Fly   373 SPMGSNGAVGAGMNATFRFEPQQQQQQQLSPMAGSPASPHCSPPRARREVPPPPRLPCKKQQRSQ 437
               |..|.                        |.||...|..    ||.:.....|...|..:|.
 Frog   355 ---GRQGG------------------------ARSPQKGHMK----RRSITMTDGLTADKINKSN 388

  Fly   438 ------SLTPAQAMLVSN----INKLQEQQLQMQELENGNGNGIMRFQTIARCNPTSEQHLESKF 492
                  |.:|....::.|    ::::|:....|..:....|:  ..:.|:.|..|
 Frog   389 GCPNSGSSSPHHRDMIRNCAVSVDQIQDLHSPMSPISETPGS--PAYSTVVRVKP---------- 441

  Fly   493 TTHSLPRPN-TSAAHALRQQAVARISSLARNCSLDSPSDSRPPSPPPKPRK-EPMAAVLAYQASG 555
                 |... |..:..||:.:...:.. |.|.:..:.:||...||....|. .|..::.:|
 Frog   442 -----PLSGATPGSPVLRRSSEPYVCP-ANNKAALNMADSHHSSPSHTHRNISPSPSINSY---- 496

  Fly   556 SDSGNG-----SGDSALGDACEASVQRGVIIKNPRFMTTSVSNGTLKSFTEFDVLAAEEELFTMA 615
            ||..||     ...|...||...|:.....::..|....:::.| ::...:.|   .:...|.:.
 Frog   497 SDPDNGHYCQLRPASPTHDALSVSLPPKSYVERLRVDECAMAGG-MRGVDDVD---RDPGCFIVP 557

  Fly   616 IEEVKTASKFDFENFVTLLLPSVENKPLDGDALNTFKMMLLETGPKLLAEHITRID--IALFLEE 678
            ..|.|  |.|:..||.:.|:|| :||||:...|...|.:..|...|.:|:|||:.|  :|..|..
 Frog   558 TMEAK--SSFNPSNFKSTLIPS-DNKPLEMSILKKVKELFAEVDAKTIAKHITKTDCEVARILCV 619

  Fly   679 PSNEEDYYLSCSGLELLTLPHGKVFREDIIERTQCIKLMVAVTILTC--QTDLDRAQLLSKWIQI 741
            ....:......||:||||||||...|.|::||...:.:|:||.||.|  .|: :||.||.|.||:
 Frog   620 TKEMQRIMGVSSGMELLTLPHGHQLRLDLLERFHTMSIMIAVDILGCTGSTE-ERAALLHKTIQL 683

  Fly   742 AVETKTALGNLFGFCAIMLGLCMQQIQKLDQAWHILRQQYTDSAFTFEAKLRPTLSIMNEA--SN 804
            |.|.|..:||:|.|.|:|..|.|.||.:|:|.|..|||::|:.|..:|.||:|.|..|||.  |.
 Frog   684 AAELKGTMGNMFSFAAVMNALEMSQISRLEQTWVALRQRHTEGAILYEKKLKPFLKSMNEGKESL 748

  Fly   805 PQAPNTTVPHVLLYALLIDRPVMDIINHSNIDDRPALYHTCIAPWESKADDFGMTINFQHLDASR 869
            |.: |||.||::....|::|            |.|.|...  .||:|  .|.|:.:...||:|:|
 Frog   749 PLS-NTTFPHIIPLITLLER------------DNPLLDGG--DPWDS--SDNGVEVVMAHLEAAR 796

  Fly   870 GFLKNLELYRKNAKIILEDASPRLDELLADAFRTEFHVKFLWGSSGATAKAEDRHNKLEKVLTLM 934
            ....:..||..||::.|:...||.|  |.:...|||.::.||||.||.....:|:||.:|||..:
 Frog   797 MVAHHGGLYHTNAEMRLQGFHPRSD--LLEVSSTEFQMRMLWGSRGALGSQVERYNKFDKVLAAL 859

  Fly   935 ADK 937
            :.|
 Frog   860 SHK 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9098	NP_608979.2	SAM_1	42..102	CDD:425739
		SH2_BCAR3	233..367	CDD:198200	60/133 (45%)
		RasGEF	660..>797	CDD:470590	61/140 (44%)
sh2d3c	XP_002935534.1	SH2_BCAR3	231..366	CDD:198200	69/177 (39%)
		RasGEF	597..865	CDD:470590	111/286 (39%)