DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9098 and SH2D3C

DIOPT Version :9

Sequence 1:	NP_608979.2	Gene:	CG9098 / 33840	FlyBaseID:	FBgn0031762	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_733745.1	Gene:	SH2D3C / 10044	HGNCID:	16884	Length:	860	Species:	Homo sapiens

Alignment Length:	964	Identity:	292/964 - (30%)
Similarity:	433/964 - (44%)	Gaps:	184/964 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LWNFRYSNTVRRREDLAVMVHNSRMSISEWLDLLELQQYEGNLQEFSTVDDVVDITDKELKQFGV 86
            |.|...|.|:||          |..|||. ...||...:|      :|.||:|.: .|....:.
Human    23 LSNLPRSFTLRR----------SSASISR-QSHLEPDTFE------ATQDDMVTV-PKSPPAYA- 68

  Fly    87 RGAHRQRMVNSLLGV--RAKRRQSMNLEAMSSAPRAVPRRKNSCPLVYLGENPQDMAGSGDSGPG 149
                |...:.|.:|.  |...:::.|.:|...|..|.|:             |..:.|.....||
Human    69 ----RSSDMYSHMGTMPRPSIKKAQNSQAARQAQEAGPK-------------PNLVPGGVPDPPG 116

  Fly   150 VITTKSGKVLKQLTFDETSTIYE-----ELRPRSKCNSPHWAIEDSR--MEGYGSSNATTPLATA 207
            :...|...|......::|..:..     |:.|..|...|...:|:.|  .:.:....|..|.|.:
Human   117 LEAAKEVMVKATGPLEDTPAMEPNPSAVEVDPIRKPEVPTGDVEEERPPRDVHSERAAGEPEAGS 181

  Fly   208 QPSPSEQQEAI------ALKKALEWELSLDARELRSHAWYHGALPRQRAEEIVQREGDFLVRDCA 266
            ......:::.|      .|.|.||.||.|.:.:|||||||||.:||:.:|.:|||.||||:||..
Human   182 DYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSL 246

  Fly   267 SQPDNYVLSCRSKAAVLHFVLNKLVLQPETVYERVQYQFEEDAFDTVPDLITFYVGSGKPISSAS 331
            :...:|||:||.:...|||.:||:|::....|..:||.||:::||.||.|:.::|||.|.:|..|
Human   247 TSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQS 311

  Fly   332 GALIQFPCNRTYPLSF----YGHKIVGNQLHTQMLAGLRGLSPLNSPMGSNGAVGAGMNATFRFE 392
            ||:|..|.|||:||.:    ||   :|           :|.|...||:..:|..|:.|.
Human   312 GAIIYCPVNRTFPLRYLEASYG---LG-----------QGSSKPASPVSPSGPKGSHMK------ 356

  Fly   393 PQQQQQQQLSPMAGSPASPHCSPPRARREVPPPPRLPCKKQQRSQSLTPAQAMLVSNINKLQEQQ 457
                                      ||.|.....|...|..||.. .|....|....:.::...
Human   357 --------------------------RRSVTMTDGLTADKVTRSDG-CPTSTSLPRPRDSIRSCA 394

  Fly   458 LQMQELENGNGNGIMRFQTIARCNPTSEQHLESKFTT----HSLPRPNTSAAHALRQQAVARISS 518
            |.|.::.:.:          :..:|.||......::|    |:.|.  ..:|.||....|||.||
Human   395 LSMDQIPDLH----------SPMSPISESPSSPAYSTVTRVHAAPA--APSATALPASPVARRSS 447

  Fly   519 LARNCSLDSP-----SDSRPPSPPPKP--RKEPMAAVLAYQASGSDSGN---------GSGDSAL 567
            ..:.|...:|     ||..|.:.|...  :..|..::.:|  |..|||:         ||.:.|
Human   448 EPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSY--SDPDSGHYCQLQPPVRGSREWA- 509

  Fly   568 GDACEASVQRGVIIKNPRFMTTSVSNG-TLKSFTEFDVLAAEE----ELFTMAIEEVKTASKFDF 627
              |.|.|.|:            :.|.| .||..:|   ..|.|    :.||:.|.||  .|.|:.
Human   510 --ATETSSQQ------------ARSYGERLKELSE---NGAPEGDWGKTFTVPIVEV--TSSFNP 555

  Fly   628 ENFVTLLLPSVENKPLDGDALNTFKMMLLETGPKLLAEHITRID--IALFLEEPSNEEDYYLSCS 690
            ..|.:||:|. :|:||:...|...|.:|.|...:.||.|:|::|  :|..|......:.......
Human   556 ATFQSLLIPR-DNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRW 619

  Fly   691 GLELLTLPHGKVFREDIIERTQCIKLMVAVTILTCQTDL-DRAQLLSKWIQIAVETKTALGNLFG 754
            |:||||||||:..|.|::||...:.:|:||.||.|.... :||.||.|.||:|.|.:..:||:|.
Human   620 GMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFS 684

  Fly   755 FCAIMLGLCMQQIQKLDQAWHILRQQYTDSAFTFEAKLRPTLSIMNEA-SNPQAPNTTVPHVLLY 818
            |.|:|..|.|.||.:|:|.|..|||::|:.|..:|.||:|.|..:||. ..|...|||.||||
Human   685 FAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVL-- 747

  Fly   819 ALLIDRPVMDIINHSNIDDRPALYHTCIAPWESKADDFGMTINFQHLDASRGFLKNLELYRKNAK 883
                  |::.::   ..|..|.   ....||.|  .:.|:.:...||:|:|....:..||..||:
Human   748 ------PLITLL---ECDSAPP---EGPEPWGS--TEHGVEVVLAHLEAARTVAHHGGLYHTNAE 798

  Fly   884 IILEDASPRLDELLADAFRTEFHVKFLWGSSGATAKAEDRHNKLEKVLTLMADK 937
            :.|:....| .||| :.|.|||.::.||||.||::....|:.|.:||||.::.|
Human   799 VKLQGFQAR-PELL-EVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHK 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9098	NP_608979.2	SAM_1	43..102	CDD:278937	15/60 (25%)
		SAM	47..103	CDD:197735	14/57 (25%)
		SH2_BCAR3	233..367	CDD:198200	60/137 (44%)
		RasGEF	660..>797	CDD:295324	57/139 (41%)
SH2D3C	NP_733745.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..117		18/90 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..180		9/49 (18%)
		SH2_BCAR3	213..347	CDD:198200	64/147 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..537		59/277 (21%)
		RasGEF	585..>754	CDD:295324	69/179 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160021
Domainoid	1	1.000	99	1.000	Domainoid score	I7090
eggNOG	1	0.900	-	-		E1_28HJ9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	318	1.000	Inparanoid score	I2546
Isobase	1	0.950	-	0	Normalized mean entropy	S7551
OMA	1	1.010	-	-		QHG49555
OrthoDB	1	1.010	-	-		D138275at2759
OrthoFinder	1	1.000	-	-		FOG0003062
OrthoInspector	1	1.000	-	-		otm40271
orthoMCL	1	0.900	-	-		OOG6_108941
Panther	1	1.100	-	-	O	PTHR14247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2423
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.720