DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gal and GLB1L2

DIOPT Version :9

Sequence 1:	NP_608978.2	Gene:	Gal / 33839	FlyBaseID:	FBgn0001089	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_001357389.1	Gene:	GLB1L2 / 89944	HGNCID:	25129	Length:	690	Species:	Homo sapiens

Alignment Length:	680	Identity:	222/680 - (32%)
Similarity:	323/680 - (47%)	Gaps:	122/680 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 FMLDGQPFRYVSGSFHYFRAVPESWRSRLRTMRASGLNALDTYVEWSLHNPHDGEYNWEGIADVV 119
            |||:...|....||.||||...|.||.||..|:|.|||.|.|||.|:||.|..|::::.|..|:.
Human    54 FMLEDSTFWIFGGSIHYFRVPREYWRDRLLKMKACGLNTLTTYVPWNLHEPERGKFDFSGNLDLE 118

  Fly   120 KFLEIAQEEDFYIILRPGPYICAERDNGGLPHWLFTKYPSIKMRTNDPNYISEVGKWYAELMPRL 184
            .|:.:|.|...::|||||||||:|.|.||||.||. :.|.:::||....:...|..::..||.|:
Human   119 AFVLMAAEIGLWVILRPGPYICSEMDLGGLPSWLL-QDPGMRLRTTYKGFTEAVDLYFDHLMSRV 182

  Fly   185 QHLFVGNGGKIIMVQVENEYGDYACDHDYLNWLRDETEKYVSGKALLFTVDIPNEKMSCGKIEN- 248
            ..|....||.||.||||||||.|..|..|:.:::...|.  .|...|.......:.:|.|.::.
Human   183 VPLQYKRGGPIIAVQVENEYGSYNKDPAYMPYVKKALED--RGIVELLLTSDNKDGLSKGIVQGD 245

  Fly   249 -----------------------------------------------------VFATTDFGIDRI 260
                                                                 |.||  ..:...
Human   246 PQPGGLCSSSRELHGCSPKLARLSVAPHLKLNFFLRGAHSILLPAFFSPSHLPVLAT--INLQST 308

  Fly   261 NEIDKIWAMLRALQPTGPLVNSEFYPGWLTHWQEQNQRRDGQEVANALRTILSYNASVNLYMFFG 325
            :|:..:...|..:|.|.|.:..|::.||...|...:...|..||...:..|:...:|:|||||.|
Human   309 HELQLLTTFLFNVQGTQPKMVMEYWTGWFDSWGGPHNILDSSEVLKTVSAIVDAGSSINLYMFHG 373

  Fly   326 GTNFGFTAGANYNLDGGIGYAADITSYDYDAVMDEAGGVTTKYNLVKAVIGEF----LP-----L 381
            ||||||..||.:..|    |.:|:||||||||:.|||..|.||..::...|..    ||     |
Human   374 GTNFGFMNGAMHFHD----YKSDVTSYDYDAVLTEAGDYTAKYMKLRDFFGSISGIPLPPPPDLL 434

  Fly   382 PEITLNPAKRLAYGRVELTPKLTLLSTEGRAALSKGDPVESIKPKTFEELDLYS------GLVLY 440
            |::...|          |||.|.|...:....|  |:|::|.||...|.|.:..      |.:||
Human   435 PKMPYEP----------LTPVLYLSLWDALKYL--GEPIKSEKPINMENLPVNGGNGQSFGYILY 487

  Fly   441 ETELPSMDLDPALLKIDQINDRAHVFVDQELVGTLSREAQIYSLPLSKGWGSTLQLLVENQGRVN 505
            ||.:.|..     :....::||..|||:...:|.|..:....::||.:|: :.|::||||:||||
Human   488 ETSITSSG-----ILSGHVHDRGQVFVNTVSIGFLDYKTTKIAVPLIQGY-TVLRILVENRGRVN 546

  Fly   506 F--YISNDTKGIFGEVSLQLHNGGYLPLENWRSTAFPLEQSAVELWRREHTDEKALDPLLARQRI 568
            :  .|.:..||:.|  :|.|::.   ||:|:|..:..:::|..:.:..:........|.|
Human   547 YGENIDDQRKGLIG--NLYLNDS---PLKNFRIYSLDMKKSFFQRFGLDKWSSLPETPTL----- 601

  Fly   569 LRNGPILYTGSLTVTEVG-DTYLNMAGWGKGVAYVNGFNLGRYWPVAGPQVTLYVPNEILKVGEN 632
                |..:.|||:::... ||:|.:.||.|||.::||.||||||.: |||.|||:|...|..|.|
Human   602 ----PAFFLGSLSISSTPCDTFLKLEGWEKGVVFINGQNLGRYWNI-GPQKTLYLPGPWLSSGIN 661

  Fly   633 SLVILEYQRANKTATGEDLPAVQFDAVAQL 662
            .:::.|     :|..|   ||:||.....|
Human   662 QVIVFE-----ETMAG---PALQFTETPHL 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gal	NP_608978.2	Glyco_hydro_35	54..376	CDD:279624	127/374 (34%)
Gal	NP_608978.2	BetaGal_dom4_5	<570..637	CDD:290101	30/67 (45%)
GLB1L2	NP_001357389.1	Glyco_hydro_35	53..417	CDD:307464	127/371 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153130
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1874
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52178
OrthoDB	1	1.010	-	-		D179316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100579
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.660