Protein Alignment Gal and GLB1L

DIOPT Version :9

• Sequence 1: NP_608978.2
• Gene: Gal / 33839
• FlyBaseID: FBgn0001089
• Length: 672
• Species: Drosophila melanogaster
• Sequence 2: NP_001273352.1
• Gene: GLB1L / 79411
• HGNCID: 28129
• Length: 654
• Species: Homo sapiens
• Alignment Length: 667
• Identity: 254/667 - (38%)
• Similarity: 343/667 - (51%)
• Gaps: 83/667 - (12%)

  Fly    17 CLIIAVMALTVGLCVGLSGDTDAPEEQPR-FTIDHEANTFMLDGQPFRYVSGSFHYFRAVPESWR 80
            ||...::.|::.|.:        |:...| |.:|...:.|:|||.||||||||.||||.....|.
Human     8 CLRSLLLPLSLTLLL--------PQADTRSFVVDRGHDRFLLDGAPFRYVSGSLHYFRVPRVLWA 64

  Fly    81 SRLRTMRASGLNALDTYVEWSLHNPHDGEYNWEGIADVVKFLEIAQEEDFYIILRPGPYICAERD 145
            .||..||.|||||:..||.|:.|.|..|.||:.|..|::.||..|...:..:|||||||||||.:
Human    65 DRLLKMRWSGLNAIQFYVPWNYHEPQPGVYNFNGSRDLIAFLNEAALANLLVILRPGPYICAEWE 129

  Fly   146 NGGLPHWLFTKYPSIKMRTNDPNYISEVGKWYAELMPRLQHLFVGNGGKIIMVQVENEYGDY-AC 209
            .||||.||..| |.|.:||:||::::.|..|:..|:|::......|||.||.:|||||||.| ||
Human   130 MGGLPSWLLRK-PEIHLRTSDPDFLAAVDSWFKVLLPKIYPWLYHNGGNIISIQVENEYGSYRAC 193

  Fly   210 DHDYLNWLRDETEKYVSGKALLFTVDIPNEKMSCGKIENVFATTDFGIDRINEIDKIWAMLRALQ 274
            |..|:..|.......:..|.||||.|.| |.:.||.:..::.|.|||  ..:.:.||:.:||..:
Human   194 DFSYMRHLAGLFRALLGEKILLFTTDGP-EGLKCGSLRGLYTTVDFG--PADNMTKIFTLLRKYE 255

  Fly   275 PTGPLVNSEFYPGWLTHWQEQNQRRDGQEVANALRTILSYNASVNLYMFFGGTNFGFTAGANYNL 339
            |.|||||||:|.|||.:|.:.:..|....|...|..:|...||||:|||.||||||:..||
Human   256 PHGPLVNSEYYTGWLDYWGQNHSTRSVSAVTKGLENMLKLGASVNMYMFHGGTNFGYWNGA---- 316

  Fly   340 DGGIGYAADITSYDYDAVMDEAGGVTTKYNLVKAVIGEFL-----PLPEITLNPAKRLAYGRV-- 397
            |....:....|||||||.:.|||..|.|...::.||.:|.     |||.    |:.::..|.|
Human   317 DKKGRFLPITTSYDYDAPISEAGDPTPKLFALRDVISKFQEVPLGPLPP----PSPKMMLGPVTL 377

  Fly   398 ----ELTPKLTLLSTEGRAALSKGDPVESIKPKTFEELDLYSGLVLYETELPSMDLDPALLKI-- 456
                .|...|.||...|        |:.||.|.|||.:....|.:||.|.:.....:|....:
Human   378 HLVGHLLAFLDLLCPRG--------PIHSILPMTFEAVKQDHGFMLYRTYMTHTIFEPTPFWVPN 434

  Fly   457 DQINDRAHVFVDQELVGTLSREAQIYSLPLSKGWGSTLQLLVENQGRVNF-YISNDTKG-----I 515
            :.::|||:|.||....|.:.|..: ..|.|:...||.|.:||||.||::| ..|:|.||     |
Human   435 NGVHDRAYVMVDGVFQGVVERNMR-DKLFLTGKLGSKLDILVENMGRLSFGSNSSDFKGLLKPPI 498

  Fly   516 FGEVSLQLHNGGYLPLENWRSTAFPLEQSAVELWRREHTDEKALDPLLARQRILRNGPILYTGSL 580
            .|:..|.......|.::|.....|||:   :..|......               :||..|:.:.
Human   499 LGQTILTQWMMFPLKIDNLVKWWFPLQ---LPKWPYPQAP---------------SGPTFYSKTF 545

  Fly   581 TVT-EVGDTYLNMAGWGKGVAYVNGFNLGRYWPVAGPQVTLYVPNEIL--KVGENSLVILEYQRA 642
            .:. .||||:|.:.||.||..::|||||||||...|||.|||||..:|  :...|.:.:||.
Human   546 PILGSVGDTFLYLPGWTKGQVWINGFNLGRYWTKQGPQQTLYVPRFLLFPRGALNKITLLEL--- 607

  Fly   643 NKTATGEDL---PAVQF 656
                  ||:   |.|||
Human   608 ------EDVPLQPQVQF 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gal	NP_608978.2	Glyco_hydro_35	54..376	CDD:279624	149/322 (46%)
		BetaGal_dom4_5	<570..637	CDD:290101	31/69 (45%)
GLB1L	NP_001273352.1	Glyco_hydro_35	38..353	CDD:307464	149/322 (46%)
		BetaGal_dom4_5	527..605	CDD:315929	32/92 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153132
Domainoid	1	1.000	327	1.000	Domainoid score	I1171
eggNOG	1	0.900	-	-		E1_COG1874
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	495	1.000	Inparanoid score	I1401
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52178
OrthoDB	1	1.010	-	-		D179316at2759
OrthoFinder	1	1.000	-	-		FOG0002046
OrthoInspector	1	1.000	-	-		mtm8540
orthoMCL	1	0.900	-	-		OOG6_100579
Panther	1	1.100	-	-	O	PTHR23421
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1174
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770