DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gal and Glb1l3

DIOPT Version :9

Sequence 1:	NP_608978.2	Gene:	Gal / 33839	FlyBaseID:	FBgn0001089	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_001019529.2	Gene:	Glb1l3 / 500961	RGDID:	1561462	Length:	644	Species:	Rattus norvegicus

Alignment Length:	634	Identity:	216/634 - (34%)
Similarity:	317/634 - (50%)	Gaps:	88/634 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VGLSGDTDAPEEQPRFTIDHEANTFMLDGQPFRYVSGSFHYFRAVPESWRSRLRTMRASGLNALD 95
            ||||.:|:|          |....|.|:|..|..|.||.||||...|.|:.||..::|.|.|.:.
  Rat    55 VGLSTETNA----------HGQAYFTLEGHKFMIVGGSIHYFRVPREYWKDRLLKLQACGFNTVT 109

  Fly    96 TYVEWSLHNPHDGEYNWEGIADVVKFLEIAQEEDFYIILRPGPYICAERDNGGLPHWLFTKYPSI 160
            ||:.|:||....|::::..|.|:..::.:|:....::|||||||||||.|.||||.||. :.|..
  Rat   110 TYIPWNLHEQERGKFDFSEILDLEAYVLLAKTLGLWVILRPGPYICAEVDLGGLPSWLL-RNPGS 173

  Fly   161 KMRTNDPNYISEVGKWYAELMPRLQHLFVGNGGKIIMVQVENEYGDYACDHDYLNWLRDETEKYV 225
            .:||.:.::|..|.|::..|:|::..|....||.:|.||||||||.:..|.:|:.:::    |.:
  Rat   174 NLRTTNKDFIEAVDKYFDHLIPKILPLQYRRGGPVIAVQVENEYGSFRNDKNYMEYIK----KAL 234

  Fly   226 SGKA---LLFTVDIPNEK-MSCGKIENVFATTDFGIDRINE-IDKIWAMLRALQPTGPLVNSEFY 285
            ..:.   ||.|.|  ||. :..|.::...||.:     :|. |...:..|..:|...|::..|::
  Rat   235 LNRGIVELLLTSD--NESGIRIGSVKGALATIN-----VNSFIKDSFVKLHRMQNDKPIMIMEYW 292

  Fly   286 PGWLTHWQEQNQRRDGQEVANALRTILSYNASVNLYMFFGGTNFGFTAGANYNLDGGI---GYAA 347
            .||...|..::..:...|:...:....||..|.|:|||.|||||||       ::||.   |:..
  Rat   293 TGWYDSWGSKHTEKSANEIRRTIYRFFSYGLSFNVYMFHGGTNFGF-------INGGYHENGHTN 350

  Fly   348 DITSYDYDAVMDEAGGVTTKYNLVKAVI--GEFLPLPEITLNPAKRL----AYGRVELTPKLTLL 406
            .:||||||||:.|||..|.||..::.:.  |...|||     |..||    .|..|.|:..|.|.
  Rat   351 VVTSYDYDAVLSEAGDYTEKYFKLRKLFASGSARPLP-----PLPRLIPKAVYPSVNLSFYLPLF 410

  Fly   407 STEGRAALSKGDPVESIKPKTFEELDLYS------GLVLYETELPSMDLDPALLKIDQINDRAHV 465
            ..  ...|:|  ||....|.|.|.|.:.:      |||||||   |:.....|..  .::|.|.|
  Rat   411 DI--LPYLNK--PVMLETPVTMENLPINNGSGQPFGLVLYET---SICFGGGLSA--SVHDSAQV 466

  Fly   466 FVDQELVGTLSREAQIYSLPLSKGWGSTLQLLVENQGRVNF--YISNDTKGIFGEVSLQLHNGGY 528
            |::.:.:|.|....:...:|..:|. ..|::|||||||:||  .|.::.||:...|::   ||..
  Rat   467 FLNDKSIGILDENNEFLHIPKIQGC-QLLRILVENQGRINFSWRIQSEQKGLNEAVTI---NGTL 527

  Fly   529 LPLENWRSTAFPLEQSAVELWRREHTDEKALDPLLARQRI---LRNGPILYTGSLTVTEV-GDTY 589
              |.|:...:..::.|..|..|.            |..||   ...||..|.|||.|... .||:
  Rat   528 --LRNFTIYSLDMKMSFFERLRS------------ASWRIAPKTYKGPAFYWGSLNVGSFPTDTF 578

  Fly   590 LNMAGWGKGVAYVNGFNLGRYWPVAGPQVTLYVPNEILKVGENSLVILE 638
            |::..|..|..::||.||||||.: |||.|||:|...|...:|.:::.|
  Rat   579 LHLPNWHYGFVFINGRNLGRYWDI-GPQKTLYLPGPWLHPEDNDVIVFE 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gal	NP_608978.2	Glyco_hydro_35	54..376	CDD:279624	118/331 (36%)
Gal	NP_608978.2	BetaGal_dom4_5	<570..637	CDD:290101	29/67 (43%)
Glb1l3	NP_001019529.2	Glyco_hydro_35	69..379	CDD:279624	118/328 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346745
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1874
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52178
OrthoDB	1	1.010	-	-		D179316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100579
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660