DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gal and glb1

DIOPT Version :9

Sequence 1:	NP_608978.2	Gene:	Gal / 33839	FlyBaseID:	FBgn0001089	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_001011038.1	Gene:	glb1 / 496447	XenbaseID:	XB-GENE-1001126	Length:	621	Species:	Xenopus tropicalis

Alignment Length:	617	Identity:	255/617 - (41%)
Similarity:	348/617 - (56%)	Gaps:	32/617 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 FTIDHEANTFMLDGQPFRYVSGSFHYFRAVPESWRSRLRTMRASGLNALDTYVEWSLHNPHDGEY 110
            |:||:..|.|..|||.|||:|||.||||.....||.||..|..:||||:..|:.|:.|.|..|.|
Frog    24 FSIDYNENCFRKDGQCFRYISGSIHYFRIPSYYWRDRLLKMYMTGLNAVQVYIPWNFHEPVPGMY 88

  Fly   111 NWEGIADVVKFLEIAQEEDFYIILRPGPYICAERDNGGLPHWLFTKYPSIKMRTNDPNYISEVGK 175
            ::.|..|:..||::..|....:|:|||||||||.|.||||.||... ..|.:||:||:|::.|..
Frog    89 DFNGDRDLSHFLDLTNELGLLVIIRPGPYICAEWDMGGLPAWLLNN-KDIALRTSDPDYLAAVDS 152

  Fly   176 WYAELMPRLQHLFVGNGGKIIMVQVENEYGDY-ACDHDYLNWLRDETEKYVSGKALLFTVDIPNE 239
            |.:.|:|:|:.....|||.||.||||||||.: |||:.||..|......|:..:.:|||.|...|
Frog   153 WLSVLLPKLRPRLYSNGGNIISVQVENEYGSFMACDYSYLRHLLHLYRLYLGDEIVLFTTDGNTE 217

  Fly   240 K-MSCGKIENVFATTDFGIDRINEIDKIWAMLRALQPTGPLVNSEFYPGWLTHWQEQNQRRDGQE 303
            | :.||.::::..|.|||..  :...|.:.:||..||.|||||||:|.|||.:|.|::.....:.
Frog   218 KELQCGSLQDLHTTVDFGPG--DNATKAFNLLRKYQPKGPLVNSEYYTGWLDYWGEKHSTTSKEL 280

  Fly   304 VANALRTILSYNASVNLYMFFGGTNFGFTAGANYNLDGGIGYAADITSYDYDAVMDEAGGVTTKY 368
            |:..|:.||...||||:|||.||||||:..||::...    |....|||||||.:.|||..|.|.
Frog   281 VSRGLKNILEMGASVNMYMFEGGTNFGYWNGADFKKT----YKPIPTSYDYDAPLSEAGDPTDKL 341

  Fly   369 NLVKAVIGEFLPLPEITL-NPAKRLAYGRVELTPKLTLLSTEGRAALSKGDPVESIKPKTFEELD 432
            |.::.||.:|.|:|:..: .|.:::.||.|.:....:||  :.....|...|.|:..|.||||:.
Frog   342 NDIRNVISQFQPVPQGPVPPPTRKMDYGFVSMNKVGSLL--DFLDVFSPEFPTETRYPLTFEEVK 404

  Fly   433 LYSGLVLYETELPSMDLDPALLKI--DQINDRAHVFVDQELVGTLSREAQIYSLPLSKGWGSTLQ 495
            .|.|.|||.|.||.....|..|..  ..::|||:|.|.....|.|.|:..:..|...|. |..|.
Frog   405 QYFGFVLYRTRLPRDVPIPTFLSSVPSGVHDRAYVSVGGVFNGVLERDHVLKILVAGKA-GDWLD 468

  Fly   496 LLVENQGRVNF-YISNDTKGIFGEVSLQLHNGGYLPLENWRSTAFPLEQSAVELWRREHTDEKAL 559
            :||||.||:|| ...||.||:...|:|    ||.: |.:|......||....|.|  .|.....:
Frog   469 VLVENMGRINFGSCVNDLKGLVSNVTL----GGDI-LTDWLLYPLNLEGPISEGW--PHVGNNFI 526

  Fly   560 DPLLARQRILRNGPILYTGSLTVTEVGDTYLNMAGWGKGVAYVNGFNLGRYWPVAGPQVTLYVPN 624
            .   ..:.....||..|:|:..:|..|||:|::..|.||.|::||||:|||||..|||:|||||.
Frog   527 G---FSETESNTGPSFYSGTFQITTQGDTFLSLPQWTKGQAWINGFNVGRYWPARGPQITLYVPG 588

  Fly   625 EILKVGENSLVILEYQRANKTATGEDLPAVQF 656
            .||::|||::.:||.:||:      :|..|.|
Frog   589 NILRLGENTVTLLELERAS------ELSVVHF 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gal	NP_608978.2	Glyco_hydro_35	54..376	CDD:279624	146/323 (45%)
Gal	NP_608978.2	BetaGal_dom4_5	<570..637	CDD:290101	35/66 (53%)
glb1	NP_001011038.1	Glyco_hydro_35	33..349	CDD:366567	146/322 (45%)
glb1	NP_001011038.1	BetaGal_dom4_5	<529..601	CDD:372580	35/71 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	313	1.000	Domainoid score	I1284
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	480	1.000	Inparanoid score	I1430
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D179316at2759
OrthoFinder	1	1.000	-	-		FOG0002046
OrthoInspector	1	1.000	-	-		mtm9432
Panther	1	1.100	-	-	O	PTHR23421
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1174
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160