DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gal and Glb1l

DIOPT Version :9

Sequence 1:	NP_608978.2	Gene:	Gal / 33839	FlyBaseID:	FBgn0001089	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_001121001.1	Gene:	Glb1l / 301525	RGDID:	1309474	Length:	646	Species:	Rattus norvegicus

Alignment Length:	640	Identity:	247/640 - (38%)
Similarity:	339/640 - (52%)	Gaps:	73/640 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 EQPRFTIDHEANTFMLDGQPFRYVSGSFHYFRAVPESWRSRLRTMRASGLNALDTYVEWSLHNPH 106
            |...|.:|.:.:.|:|||.||||:|||.||||.....|..||..|:.|||||:..||.|:.|.|.
  Rat    22 EARSFVVDRQHDRFLLDGVPFRYISGSLHYFRVPRVLWADRLLKMKLSGLNAVQFYVPWNYHEPE 86

  Fly   107 DGEYNWEGIADVVKFLEIAQEEDFYIILRPGPYICAERDNGGLPHWLFTKYPSIKMRTNDPNYIS 171
            .|.||:.|..|:..||..|.:.:..:|||||||||||.:.||||.||. :...|.:||:||.::.
  Rat    87 PGIYNFNGSRDLTAFLNEAAKANLLVILRPGPYICAEWEMGGLPSWLL-RNRDIHLRTSDPAFLH 150

  Fly   172 EVGKWYAELMPRLQHLFVGNGGKIIMVQVENEYGDY-ACDHDYLNWLRDETEKYVSGKALLFTVD 235
            .|..|:..|:|::......|||.||.:|||||||.| .||..|:..|.......:..:.||||.|
  Rat   151 AVDSWFKVLLPKIYPFLYHNGGNIISIQVENEYGSYKVCDFKYMRHLAGLFRALLGDEILLFTTD 215

  Fly   236 IPNEKMSCGKIENVFATTDFGIDRINEIDKIWAMLRALQPTGPLVNSEFYPGWLTHWQEQNQRRD 300
            .| :.:.||.::.::||.|||  ..:.:.:|:::||..:|.|||||||:|.|||.:|.:.:..|.
  Rat   216 GP-QGLRCGSLQGLYATVDFG--PADNVTRIFSLLREYEPHGPLVNSEYYTGWLDYWGQNHSTRS 277

  Fly   301 GQEVANALRTILSYNASVNLYMFFGGTNFGFTAGANYNLDGGIGYAADI-TSYDYDAVMDEAGGV 364
            ...||..|..||...||||:|||.||||||:..||:..     ||...| |||||||.:.|||..
  Rat   278 TPAVARGLERILKLGASVNMYMFHGGTNFGYWNGADDK-----GYFLPITTSYDYDAPISEAGDP 337

  Fly   365 TTKYNLVKAVIGEF--LPL-------PEITLNPAKRLAYGRVELTPKLTLLSTEGRAALSKGDPV 420
            |.|...::.||.:|  :||       |::.|.|......|  .|...|..|..||        |:
  Rat   338 TPKLFAIQNVISKFQEIPLGPLPPPSPKMKLGPLTMSLDG--NLLSFLDFLCPEG--------PI 392

  Fly   421 ESIKPKTFEELDLYSGLVLYETELPSMDLDPALLKI--DQINDRAHVFVDQELVGTLSR--EAQI 481
            .|:.|.|||.:.|..|.:||.|.:.....:|..|.:  :.|:|||:|.||..|.|.|.|  :.::
  Rat   393 HSVLPLTFEAVKLDRGFMLYRTYMTYTVSEPTPLWVPNNGIHDRAYVMVDGVLKGILERSLKEEL 457

  Fly   482 YSLPLSKGWGSTLQLLVENQGRVNFYIS-NDTKGIFGEVSLQLHNGGYLPLENWRSTAFPLEQSA 545
            |   |:...|:.|.:|:||.||::|..: :|.||:.....|     |...|..|  ..|||:...
  Rat   458 Y---LTGKVGTRLDILLENMGRLSFGSNHSDFKGLLEPPLL-----GQTVLTGW--MMFPLKVDK 512

  Fly   546 VELWRREHTDEKALDPLLARQRILRNG---PILYTGSL-TVTEVGDTYLNMAGWGKGVAYVNGFN 606
            :..|         ..||...:|.....   |..|:... .:..:|||:|.:.||.||..::||||
  Rat   513 LVKW---------WIPLQLMKRAQPQAPSVPAFYSAKFPALGLLGDTFLYLPGWTKGQVWINGFN 568

  Fly   607 LGRYWPVAGPQVTLYVPNEILKVGE--NSLVILEYQRANKTATGEDL---PAVQF 656
            |||||.:.|||.|||||..:| .|.  |.:.:||.         ||:   |.:||
  Rat   569 LGRYWTMRGPQQTLYVPRPLL-FGSSINKITLLEL---------EDVPHDPQIQF 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gal	NP_608978.2	Glyco_hydro_35	54..376	CDD:279624	146/323 (45%)
Gal	NP_608978.2	BetaGal_dom4_5	<570..637	CDD:290101	30/72 (42%)
Glb1l	NP_001121001.1	Glyco_hydro_35	34..349	CDD:279624	146/323 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346743
Domainoid	1	1.000	336	1.000	Domainoid score	I1084
eggNOG	1	0.900	-	-		E1_COG1874
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	513	1.000	Inparanoid score	I1255
OMA	1	1.010	-	-		QHG52178
OrthoDB	1	1.010	-	-		D179316at2759
OrthoFinder	1	1.000	-	-		FOG0002046
OrthoInspector	1	1.000	-	-		mtm9014
orthoMCL	1	0.900	-	-		OOG6_100579
Panther	1	1.100	-	-	O	PTHR23421
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1174
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770