Protein Alignment Gal and GLB1

DIOPT Version :9

• Sequence 1: NP_608978.2
• Gene: Gal / 33839
• FlyBaseID: FBgn0001089
• Length: 672
• Species: Drosophila melanogaster
• Sequence 2: NP_001303969.2
• Gene: GLB1 / 2720
• HGNCID: 4298
• Length: 725
• Species: Homo sapiens
• Alignment Length: 632
• Identity: 261/632 - (41%)
• Similarity: 362/632 - (57%)
• Gaps: 40/632 - (6%)

  Fly    43 QPRFTIDHEANTFMLDGQPFRYVSGSFHYFRAVPESWRSRLRTMRASGLNALDTYVEWSLHNPHD 107
            |..|.||:..::|:.|||||||:|||.||.|.....|:.||..|:.:||||:.|||.|:.|.|..
Human    77 QRMFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWP 141

  Fly   108 GEYNWEGIADVVKFLEIAQEEDFYIILRPGPYICAERDNGGLPHWLFTKYPSIKMRTNDPNYISE 172
            |:|.:....||..||.:|.|....:|||||||||||.:.||||.||..| .||.:|::||:|::.
Human   142 GQYQFSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEK-ESILLRSSDPDYLAA 205

  Fly   173 VGKWYAELMPRLQHLFVGNGGKIIMVQVENEYGDY-ACDHDYLNWLRDETEKYVSGKALLFTVDI 236
            |.||...|:|:::.|...|||.:|.||||||||.| |||.|||.:|:.....::....:|||.|.
Human   206 VDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDG 270

  Fly   237 PNEK-MSCGKIENVFATTDFGIDRINEIDKIWAMLRALQPTGPLVNSEFYPGWLTHWQEQNQRRD 300
            .::. :.||.::.::.|.|||..  :.|...:...|..:|.|||:|||||.|||.||.:.:....
Human   271 AHKTFLKCGALQGLYTTVDFGTG--SNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIK 333

  Fly   301 GQEVANALRTILSYNASVNLYMFFGGTNFGFTAGANYNLDGGIGYAADITSYDYDAVMDEAGGVT 365
            .:.||::|..||:..||||||||.|||||.:..|||      ..|||..|||||||.:.|||.:|
Human   334 TEAVASSLYDILARGASVNLYMFIGGTNFAYWNGAN------SPYAAQPTSYDYDAPLSEAGDLT 392

  Fly   366 TKYNLVKAVIGEFLPLPEITLNPA-KRLAYGRVELTPKLTLLSTEGRA--ALSKGDPVESIKPKT 427
            .||..::.:|.:|..:||..:.|: .:.|||:|.|..    |.|.|.|  .|....|::|:.|.|
Human   393 EKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEK----LKTVGAALDILCPSGPIKSLYPLT 453

  Fly   428 FEELDLYSGLVLYETELPSMDLDPALLK--IDQINDRAHVFVDQELVGTLSREAQIYSLPLSKGW 490
            |.::..:.|.|||.|.||....:||.|.  ::.::|||:|.||....|.|.|. .:.:|.::...
Human   454 FIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERN-NVITLNITGKA 517

  Fly   491 GSTLQLLVENQGRVNF--YISNDTKGIFGEVSLQLHNGGYLPLENWRSTAFPLE-QSAV--ELWR 550
            |:||.|||||.||||:  || ||.||:...::|..:     .|.:|  |.|||: :.||  .|..
Human   518 GATLDLLVENMGRVNYGAYI-NDFKGLVSNLTLSSN-----ILTDW--TIFPLDTEDAVCSHLGG 574

  Fly   551 REHTDEKALDPLLARQRILRNGPILYTGSLTVTE-----VGDTYLNMAGWGKGVAYVNGFNLGRY 610
            ..|.|....|...|........|..|.|:.::..     ..||::...||.||..::||||||||
Human   575 WGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRY 639

  Fly   611 WPVAGPQVTLYVPNEILKV-GENSLVILEYQRANKTATGEDLPAVQF 656
            ||..|||:||:||..||.. ..|::.:||.:.|..::...:|.||.|
Human   640 WPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTF 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gal	NP_608978.2	Glyco_hydro_35	54..376	CDD:279624	149/323 (46%)
		BetaGal_dom4_5	<570..637	CDD:290101	29/72 (40%)
GLB1	NP_001303969.2	Glyco_hydro_35	88..402	CDD:396048	149/322 (46%)
		BetaGal_dom4_5	<599..667	CDD:404274	28/67 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153128
Domainoid	1	1.000	327	1.000	Domainoid score	I1171
eggNOG	1	0.900	-	-		E1_COG1874
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	495	1.000	Inparanoid score	I1401
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52178
OrthoDB	1	1.010	-	-		D179316at2759
OrthoFinder	1	1.000	-	-		FOG0002046
OrthoInspector	1	1.000	-	-		mtm8540
orthoMCL	1	0.900	-	-		OOG6_100579
Panther	1	1.100	-	-	O	PTHR23421
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1174
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770