DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gal and GLB1L3

DIOPT Version :9

Sequence 1:	NP_608978.2	Gene:	Gal / 33839	FlyBaseID:	FBgn0001089	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	XP_011540868.1	Gene:	GLB1L3 / 112937	HGNCID:	25147	Length:	700	Species:	Homo sapiens

Alignment Length:	662	Identity:	229/662 - (34%)
Similarity:	323/662 - (48%)	Gaps:	109/662 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 APEEQPRFTIDH---------------EAN-----TFMLDGQPFRYVSGSFHYFRAVPESWRSRL 83
            |...||||...|               |:.     .|.|:|..|....||.||||...|.||.||
Human    91 AHPSQPRFNWSHLTPLELKNRSVGLGTESTGRGKPHFTLEGHKFLIFGGSIHYFRVPREYWRDRL 155

  Fly    84 RTMRASGLNALDTYVEWSLHNPHDGEYNWEGIADVVKFLEIAQEEDFYIILRPGPYICAERDNGG 148
            ..::|.|.|.:.|||.|:||.|..|::::.|..|:..|:.:|.|...::|||||.|||:|.|.||
Human   156 LKLKACGFNTVTTYVPWNLHEPERGKFDFSGNLDLEAFVLMAAEIGLWVILRPGRYICSEMDLGG 220

  Fly   149 LPHWLFTKYPSIKMRTNDPNYISEVGKWYAELMPRLQHLFVGNGGKIIMVQVENEYGDYACDHDY 213
            ||.||. :.|.:.:||.:.::|..|.|::..|:||:..|.....|.:|.||||||||.:..|..|
Human   221 LPSWLL-QDPRLLLRTTNKSFIEAVEKYFDHLIPRVIPLQYRQAGPVIAVQVENEYGSFNKDKTY 284

  Fly   214 LNWLRDETEKYVSGKA--------LLFTVDIPNEKMSCGKIENVFATTD---FGIDRINEIDKIW 267
            :.:|.         ||        ||.|.|.....:| |..:.|.|..:   ...|..|::.|:
Human   285 MPYLH---------KALLRRGIVELLLTSDGEKHVLS-GHTKGVLAAINLQKLHQDTFNQLHKV- 338

  Fly   268 AMLRALQPTGPLVNSEFYPGWLTHWQEQNQRRDGQEVANALRTILSYNASVNLYMFFGGTNFGFT 332
                  |...||:..|::.||...|.:::..:|.:||.:|:...:.|..|.|:|||.|||||||.
Human   339 ------QRDKPLLIMEYWVGWFDRWGDKHHVKDAKEVEHAVSEFIKYEISFNVYMFHGGTNFGFM 397

  Fly   333 AGANY-NLDGGIGYAADITSYDYDAVMDEAGGVTTKY----NLVKAVIGEFLPLPEITLNPAKRL 392
            .||.| ....||     :||||||||:.|||..|.||    .|.::|  ...|||.:...|.|.:
Human   398 NGATYFGKHSGI-----VTSYDYDAVLTEAGDYTEKYLKLQKLFQSV--SATPLPRVPKLPPKAV 455

  Fly   393 AYGRVELTPKLTLLSTEGRAALSKGDPVESIKPKTFEELDLYS------GLVLYETELPSMDLDP 451
             |..|.  |.|.|...:..:.|:  :||.|.:|...|.|.:.:      ||||||..:.|.....
Human   456 -YPPVR--PSLYLPLWDALSYLN--EPVRSRQPVNMENLPINNGSGQSYGLVLYEKSICSGGRLR 515

  Fly   452 ALLKIDQINDRAHVFVDQELVGTLSREAQIYSLPLSKGWGSTLQLLVENQGRVNF--YISNDTKG 514
            |     ..:|.|.||:|:.::|.|:...:...:|..:.. ..|::||||||||||  .|.|:.||
Human   516 A-----HAHDVAQVFLDETMIGILNENNKDLHIPELRDC-RYLRILVENQGRVNFSWQIQNEQKG 574

  Fly   515 IFGEVSLQLHNGGYLPLENWRSTAFPLEQSAVELWR-REHTDEKALDPLLARQRILRNGPILYTG 578
            |.|.||  ::|..   ||.:  |.:.||.......| |..|.:...|.        ..||..|.|
Human   575 ITGSVS--INNSS---LEGF--TIYSLEMKMSFFERLRSATWKPVPDS--------HQGPAFYCG 624

  Fly   579 SLTVTEVG----DTYLNMAGWGKGVAYVNGFNLGRYWPVAGPQVTLYVPNEILKVGENSLVILEY 639
            :|   :.|    ||:|::..|..|..::||.||||||.: |||.|||:|...|...:|.:::.|
Human   625 TL---KAGPSPKDTFLSLLNWNYGFVFINGRNLGRYWNI-GPQKTLYLPGVWLHPEDNEVILFE- 684

  Fly   640 QRANKTATGEDL 651
                |..:|.|:
Human   685 ----KMMSGSDI 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gal	NP_608978.2	Glyco_hydro_35	54..376	CDD:279624	128/337 (38%)
Gal	NP_608978.2	BetaGal_dom4_5	<570..637	CDD:290101	28/70 (40%)
GLB1L3	XP_011540868.1	Glyco_hydro_35	127..435	CDD:279624	126/330 (38%)
GLB1L3	XP_011540868.1	BetaGal_dom4_5	606..678	CDD:290101	29/83 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153134
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1874
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52178
OrthoDB	1	1.010	-	-		D179316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100579
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.660