DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gal and glb1l

DIOPT Version :9

Sequence 1:	NP_608978.2	Gene:	Gal / 33839	FlyBaseID:	FBgn0001089	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_001116328.1	Gene:	glb1l / 100001628	ZFINID:	ZDB-GENE-050309-196	Length:	629	Species:	Danio rerio

Alignment Length:	612	Identity:	250/612 - (40%)
Similarity:	344/612 - (56%)	Gaps:	45/612 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 FTIDHEANTFMLDGQPFRYVSGSFHYFRAVPESWRSRLRTMRASGLNALDTYVEWSLHNPHDGEY 110
            |:||::.|.|..||:||:|:|||.||.|...|.|:.||..|..:||||:..||.|:.|....|.|
Zfish    27 FSIDYKNNCFRKDGKPFQYISGSIHYSRIPREYWQDRLLKMYMTGLNAIQVYVPWNFHETVQGVY 91

  Fly   111 NWEGIADVVKFLEIAQEEDFYIILRPGPYICAERDNGGLPHWLFTKYPSIKMRTNDPNYISEVGK 175
            |:.|..|:..||.:|.:....:|||||||||||.:.||||.||..| |:|.:|:.|..|:.....
Zfish    92 NFAGDRDLEYFLNLANQTGLLVILRPGPYICAEWEMGGLPAWLLQK-PNIILRSADKEYLQAASD 155

  Fly   176 WYAELMPRLQHLFVGNGGKIIMVQVENEYGDY-ACDHDYLNWLRDETEKYVSGKALLFTVDIPNE 239
            |.|.|:.:::.....|||.||.||||||||.| |||::|:..|......::....:|||.|...:
Zfish   156 WLAVLLAKMRPWLYQNGGNIISVQVENEYGSYFACDYNYMRHLHTLFRLFLGEDVILFTTDGNTD 220

  Fly   240 K-MSCGKIENVFATTDFGIDRINEIDKIWAMLRALQPTGPLVNSEFYPGWLTHWQEQNQRRDGQE 303
            | ||||.:|.::||.|||.|  ..|...:...|..:|.|||||||||.|||.||.:::...|..:
Zfish   221 KEMSCGTLEGLYATIDFGTD--TNITTAFIRQRRFEPKGPLVNSEFYTGWLDHWGDKHASVDTNK 283

  Fly   304 VANALRTILSYNASVNLYMFFGGTNFGFTAGANYNLDGGIGYAADITSYDYDAVMDEAGGVTTKY 368
            |:..|..:||..||||:|||.||||||:..||:::    ..:.:.:|||||:|.:.|||..|.|.
Zfish   284 VSKMLGEMLSMGASVNMYMFEGGTNFGYWNGADHD----TRFRSVVTSYDYNAPLTEAGDPTDKL 344

  Fly   369 NLVKAVIGEFLPLPEITLNPA-KRLAYGRVEL------TPKLTLLSTEGRAALSKGDPVESIKPK 426
            ..::.||..|..:|...:.|| .:||||.|.|      :..|..||.:|        ||.|..|.
Zfish   345 LAIRDVIKNFRDIPVGPMPPATPKLAYGFVTLHKVGNISSLLDTLSPQG--------PVRSQYPL 401

  Fly   427 TFEELDLYSGLVLYETELPS--MDLDPALLKIDQINDRAHVFVDQELVGTLSREAQIYSLPLSKG 489
            ||||:..|.|.:||.|.||.  .:..|.:..::.|:|||:|.|:....|.:.|:..:. :.::..
Zfish   402 TFEEIKQYYGFLLYRTTLPRNVPEPTPLISPLNGIHDRAYVSVNGVYQGLMERDTGLV-MNITGR 465

  Fly   490 WGSTLQLLVENQGRVNF--YISNDTKGIFGEVSLQLHNGGYLPLENWRSTAFPLEQSAVELWRRE 552
            .|..|.:||||.|||||  || ||.||:.|.:.|     |...|.:|......::.:....|.
Zfish   466 QGDQLDILVENMGRVNFGSYI-NDNKGLLGNLIL-----GNDVLSDWSVYPLDIDTAVANGWL-- 522

  Fly   553 HTDEKALDPLLARQRILRNGPILYTGSLTVT-EVGDTYLNMAGWGKGVAYVNGFNLGRYWPVAGP 616
               :.|...||..   ..:|||.|:|:|..| ...||::.:.||.||..:|||||||||||..||
Zfish   523 ---QSAHSGLLTE---AGDGPIFYSGTLKPTGRAWDTFVKLNGWTKGQVWVNGFNLGRYWPKRGP 581

  Fly   617 QVTLYVPNEILKVGE-NSLVILEYQRA 642
            |.|||||...|...: |::.:||.:||
Zfish   582 QQTLYVPGPFLSANQLNNITVLELERA 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gal	NP_608978.2	Glyco_hydro_35	54..376	CDD:279624	143/323 (44%)
Gal	NP_608978.2	BetaGal_dom4_5	<570..637	CDD:290101	34/68 (50%)
glb1l	NP_001116328.1	Glyco_hydro_35	36..352	CDD:279624	143/322 (44%)
glb1l	NP_001116328.1	BetaGal_dom4_5	<536..603	CDD:290101	34/66 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588187
Domainoid	1	1.000	320	1.000	Domainoid score	I1213
eggNOG	1	0.900	-	-		E1_COG1874
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	482	1.000	Inparanoid score	I1415
OMA	1	1.010	-	-		QHG52178
OrthoDB	1	1.010	-	-		D179316at2759
OrthoFinder	1	1.000	-	-		FOG0002046
OrthoInspector	1	1.000	-	-		mtm6428
orthoMCL	1	0.900	-	-		OOG6_100579
Panther	1	1.100	-	-	O	PTHR23421
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1174
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770