Protein Alignment Tsp26A and CD63

DIOPT Version :10

• Sequence 1: NP_001097093.1
• Gene: Tsp26A / 33838
• FlyBaseID: FBgn0031760
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_001771.1
• Gene: CD63 / 967
• HGNCID: 1692
• Length: 238
• Species: Homo sapiens
• Alignment Length: 634
• Identity: 122/634 - (19%)
• Similarity: 207/634 - (32%)
• Gaps: 167/634 - (26%)

  Fly    75 EIQAFRSVVFRDLLESEKAHVAELRGLSENFLEPLEGSQILSSNEYTQLMCNFLEVVEMHEEFLQ 139
            |:.|.....|..|:|.::...||:|...:|.::.:                    :::....:::
Human    37 EVPASMMKQFNALMEMQEVMFAEMRETYKNDIKEM--------------------LLKRTAPWVK 81

  Fly   140 TLEDCNDRVGKV---FLSNAPTM-KKIHQFYCAAHPRAIVIVDKFRDELNVFME--KQGAAKPGL 198
            .||   :|:|:.   .:|..|.. :|:.:....        .|:..:.|.|..:  ||..|||
Human    82 HLE---ERIGQQEGDAISERPKPGEKVEELSSG--------TDEDTENLTVRSKKGKQDKAKP-- 133

  Fly   199 LVLTTGLSKPFRRLDKYAAILQELERHMES--GHPDRGDTQRSIAVYKDI------ASSCSATRR 255
                         |:....:...|||..|:  |...|.....|:..:|:.      .:||.:...
Human   134 -------------LNSSHVLKSSLERGGEALRGEHGRCGESSSLVDWKNANEKPAREASCQSEEN 185

  Fly   256 QKELELQILTGPVRGWQGAELSTLGDIIHMGSVAVGPEHKDRYLVLFPQTL---LILSVSQRMSA 317
            :.:...:   .|..|..||.|....| ....::.||.:....:.:|..:.|   |..||.   .|
Human   186 RLKAPKE---SPPEGGAGATLRLAAD-FSAATLDVGRQWSQVFRLLKEKELEPELQCSVK---LA 243

  Fly   318 FKYEGKLPLTGITVNRLEDTDQLKNAFEISGTLIDRIVAVCQGPNEANRWVELLSPKSGAAEQGN 382
            ||.:|:       .|...|...|:. |......:..::......||..|..||       .|:..
Human   244 FKCDGE-------ANVFSDLHSLRQ-FTSRKPFLRELLKDVFPQNEGGRRNEL-------RERLG 293

  Fly   383 TGAVDMK---RNVSSSAVNIPQPPPHVSMLMSAARAVPSEHGKNDANSTEQRTSKEGDAECNVRK 444
            ....|.|   |.::|.:         :|.|......|.|...|.....|..|.:|      ...|
Human   294 KTLGDTKHEARRIASDS---------LSFLFIKEVEVASPEVKTYKEETLDRKNK------GTLK 343

  Fly   445 ECHSRERSYNSTD----SDNESLKLPPASGPLSRPMSPRSPCIGDSSNSSSTNSSKPTTSQAGVF 505
            :....|...:.|.    |:.|:.:|....|..|....       :||.|.....|..:..:.|..
Human   344 KQEGEEEEISETQGEETSEGETSELGEEEGSESEEEE-------ESSESEEEEESSESAEEIGFI 401

  Fly   506 PSGGDGLSHRPNISSNGAAARGSGKRVFSVLFELALSN--WN----------------ITNLRPA 552
            ....|..|...  .:...|::...|..|..|.|||.|.  |:                .:..|..
Human   402 SLVVDSESEEE--VNRKTASQTKKKETFHGLKELAFSYLVWDSKKKKLVRCQEGGAAAASTQRIG 464

  Fly   553 PPLRPAFLSSVAVS-GAGSAGGGTGG--GRSATASITGSIGG------AAASCVSPTYEEDALVL 608
            .|....:|:|.:.| ||||.|..:..  ..||.:.:|..:..      .......||.:|..|:|
Human   465 MPCLTLYLTSPSESLGAGSDGPKSHSCTKLSALSQVTPLLTNIEKGRYKVPQTEEPTAKEADLIL 529

  Fly   609 RVIEAYCAAYQSTSRNTMHSGVEYDEMTPTLRQLFISVRQLQQDMAQVK 657
            ...|.:                        .|.:...:||:|:::.::|
Human   530 ETEENF------------------------KRGVISVIRQMQREVDKIK 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp26A	NP_001097093.1	Tetraspanin	19..194	CDD:459767	21/124 (17%)
		TM4SF9_like_LEL	118..239	CDD:239412	22/128 (17%)
CD63	NP_001771.1	Tetraspanin	10..229	CDD:459767	44/241 (18%)
		CD63_LEL	105..203	CDD:239419	23/123 (19%)
		Lysosomal targeting motif. /evidence=ECO:0000250|UniProtKB:P41731	234..238		1/3 (33%)