Protein Alignment Tsp26A and TSPAN18

DIOPT Version :10

• Sequence 1: NP_001097093.1
• Gene: Tsp26A / 33838
• FlyBaseID: FBgn0031760
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: XP_005253274.1
• Gene: TSPAN18 / 90139
• HGNCID: 20660
• Length: 258
• Species: Homo sapiens
• Alignment Length: 271
• Identity: 82/271 - (30%)
• Similarity: 135/271 - (49%)
• Gaps: 45/271 - (16%)

  Fly     9 RRETSEISC--CLKYLLFASNVILWLSALLVLSVGIWAWSEKGMFRNIARLHFIALDPAFVLIIL 71
            |..|.|..|  |:|||:|..|..::|....:|::|||...:...||.|...:.:.|..|::|:.:
Human     7 RWSTMEGDCLSCMKYLMFVFNFFIFLGGACLLAIGIWVMVDPTGFREIVAANPLLLTGAYILLAM 71

  Fly    72 GGVTFLLGFMGSVGALRENTCLLGAYAIFLSVLLIAEIGFCAVAFVLKDKGWIKDQATEGLKAFI 136
            ||:.|||||:|..||:|||.|||..:.:|:.::.:||:....:||:.:: ...::..|   |...
Human    72 GGLLFLLGFLGCCGAVRENKCLLLFFFLFILIIFLAELSAAILAFIFRE-NLTREFFT---KELT 132

  Fly   137 RHYREDADQQNLIDWIQEDW------LQCCGIDGPKDWDSNNYFNCSSIAIGSREACGVPFSCCR 195
            :||:.:.|    .|.....|      ..|||::||:|:...:.|..  :.:.|.|   ||.:|||
Human   133 KHYQGNND----TDVFSATWNSVMITFGCCGVNGPEDFKFASVFRL--LTLDSEE---VPEACCR 188

  Fly   196 RRPQE----VIKNKQC----GYDVRKEG-YPVDRNIHERGCLRAGEDWLEAHLISVAIGCVALLV 251
            |.||.    ::..::|    ...:.|:| |.|..|..|.....||         ::|||.:|:
Human   189 REPQSRDGVLLSREECLLGRSLFLNKQGCYTVILNTFETYVYLAG---------ALAIGVLAI-- 242

  Fly   252 LQGMELSKIIY 262
                ||..:|:
Human   243 ----ELFAMIF 249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp26A	NP_001097093.1	Tetraspanin	19..194	CDD:459767	55/180 (31%)
		TM4SF9_like_LEL	118..239	CDD:239412	33/135 (24%)
TSPAN18	XP_005253274.1	Tetraspanin	20..255	CDD:459767	77/258 (30%)
		uroplakin_I_like_LEL	115..228	CDD:239409	33/125 (26%)