Protein Alignment Tsp26A and TSPAN8

DIOPT Version :10

• Sequence 1: NP_001097093.1
• Gene: Tsp26A / 33838
• FlyBaseID: FBgn0031760
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_004607.1
• Gene: TSPAN8 / 7103
• HGNCID: 11855
• Length: 237
• Species: Homo sapiens
• Alignment Length: 262
• Identity: 65/262 - (24%)
• Similarity: 125/262 - (47%)
• Gaps: 48/262 - (18%)

  Fly    15 ISCCLKYLLFASNVILWLSALLVLSVGIW---AWSEKGMF--RNIARLHFIALDPAFVLIILGGV 74
            :|.|:||.:|..|.:.||..:|:|::.||   :...:.:|  .::....::|:|   :||.:|.:
Human     4 VSACIKYSMFTFNFLFWLCGILILALAIWVRVSNDSQAIFGSEDVGSSSYVAVD---ILIAVGAI 65

  Fly    75 TFLLGFMGSVGALRENTCLLGAYAIFLSVLLIAEI--GFCAVAFVLKDKGWIKDQATEGLKAFIR 137
            ..:|||:|..||::|:.|:|..:.|.|.::|:.::  |.....|..|....:.:...|..|....
Human    66 IMILGFLGCCGAIKESRCMLLLFFIGLLLILLLQVATGILGAVFKSKSDRIVNETLYENTKLLSA 130

  Fly   138 HYREDADQQNLIDWIQEDWLQCCG-IDGPKDWDSN--NYFNCSSIAIGSREACGVPFSCC-RRRP 198
            ....:...|..|...||:: :||| ::|..||.:|  :|          .|.|    :|. ::||
Human   131 TGESEKQFQEAIIVFQEEF-KCCGLVNGAADWGNNFQHY----------PELC----ACLDKQRP 180

  Fly   199 QEVIKNKQCGYDVRKEGYPVDRNIHERGCLRAGEDWLEAHLISVAIGC---VALLVLQGMELSKI 260
            .:....||               :::..|:...:|:|..:|| :.||.   :|::.:.|:..|.:
Human   181 CQSYNGKQ---------------VYKETCISFIKDFLAKNLI-IVIGISFGLAVIEILGLVFSMV 229

  Fly   261 IY 262
            :|
Human   230 LY 231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp26A	NP_001097093.1	Tetraspanin	19..194	CDD:459767	47/184 (26%)
		TM4SF9_like_LEL	118..239	CDD:239412	25/124 (20%)
TSPAN8	NP_004607.1	Tetraspanin	8..232	CDD:459767	63/258 (24%)
		hydrophobic region	10..33		8/22 (36%)
		hydrophobic region	58..78		8/19 (42%)
		hydrophobic region	83..109		6/25 (24%)
		TM4SF3_like_LEL	106..206	CDD:239407	26/129 (20%)
		hydrophobic region	206..232		8/27 (30%)