Protein Alignment Tsp26A and PRPH2

DIOPT Version :10

• Sequence 1: NP_001097093.1
• Gene: Tsp26A / 33838
• FlyBaseID: FBgn0031760
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_000313.2
• Gene: PRPH2 / 5961
• HGNCID: 9942
• Length: 346
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 71/296 - (23%)
• Similarity: 113/296 - (38%)
• Gaps: 117/296 - (39%)

  Fly    30 LW-------LSALLVLSVGIWAWSE---KGMFRNIARLHFI------------------------ 60
            ||       |:.:::.|:|::...|   :....|.:..||:
Human    20 LWLMNWFSVLAGIIIFSLGLFLKIELRKRSDVMNNSESHFVPNSLIGMGVLSCVFNSLAGKICYD 84

  Fly    61 ALDPA-----------FVLIILGGVTFLLGFMGSVGALRENTCLLGAYAIFLSVLLIAEIGFCAV 114
            |||||           ::.|                      |:|....:||       :..|
Human    85 ALDPAKYARWKPWLKPYLAI----------------------CVLFNIILFL-------VALC-- 118

  Fly   115 AFVLKDKGWIKDQATEGLKAFIRHYREDAD------QQNLIDWIQEDWLQCCGIDGPKD-----W 168
            .|:|  :|.:::...:|||..:::|| |.|      .:..||.:|.:: :|||.:|.:|     |
Human   119 CFLL--RGSLENTLGQGLKNGMKYYR-DTDTPGRCFMKKTIDMLQIEF-KCCGNNGFRDWFEIQW 179

  Fly   169 DSNNYFNCSSIAIGSREAC---------GVPFSCCR---RRP--QEVIKNKQC--GYDVRKEGYP 217
            .||.|.:.||..:..|...         |||||||.   .||  |..|.|...  .||.:.|
Human   180 ISNRYLDFSSKEVKDRIKSNVDGRYLVDGVPFSCCNPSSPRPCIQYQITNNSAHYSYDHQTE--- 241

  Fly   218 VDRNIHERGCLRAGEDWLEAHLISV--AIGCVALLV 251
             :.|:..|||..|    |.::..|:  ::|.|.||:
Human   242 -ELNLWVRGCRAA----LLSYYSSLMNSMGVVTLLI 272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp26A	NP_001097093.1	Tetraspanin	19..194	CDD:459767	50/228 (22%)
		TM4SF9_like_LEL	118..239	CDD:239412	45/147 (31%)
PRPH2	NP_000313.2	Tetraspanin	16..181	CDD:459767	39/195 (20%)
		peripherin_like_LEL	120..262	CDD:239415	47/153 (31%)
		Interaction with MREG. /evidence=ECO:0000250	341..346