DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsp26A and Tspan17

DIOPT Version :9

Sequence 1:	NP_001097093.1	Gene:	Tsp26A / 33838	FlyBaseID:	FBgn0031760	Length:	314	Species:	Drosophila melanogaster
Sequence 2:	XP_006253692.1	Gene:	Tspan17 / 306771	RGDID:	1311167	Length:	281	Species:	Rattus norvegicus

Alignment Length:	314	Identity:	126/314 - (40%)
Similarity:	178/314 - (56%)	Gaps:	45/314 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAAVRKFRRETSEISCCLKYLLFASNVILWLSALLVLSVGIWAWSEKGMFRNIARLHFI-ALDP 64
            ||...::|  :..|:.||.||.||..|::.|:...|.|::|:|||.|||:..||:.|..: .|||
  Rat     1 MPGKHQQF--QDPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWGEKGVLSNISGLTDLGGLDP 63

  Fly    65 AFVLIILGGVTFLLGFMGSVGALRENTCLLGAYAIFLSVLLIAEIGFCAVAFVLKDKGWIKDQAT 129
            .::.:::||:..:|||.|.:|||||||.||..:::||.::...|:....:|||.||  ||:||..
  Rat    64 VWLFVVIGGIMSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELAAGILAFVFKD--WIRDQLN 126

  Fly   130 EGLKAFIRHYREDADQQNLIDWIQEDWLQCCGIDGPKDWDSNNYFNCSSIAIGSREACGVPFSCC 194
            ..:...::.||:|.|.|||||:.||.| .|||..||.||:.|.||||:.:. .|||.||||||||
  Rat   127 LFINNNVKAYRDDIDLQNLIDFAQEYW-SCCGARGPNDWNLNIYFNCTDLN-PSRERCGVPFSCC 189

  Fly   195 RRRPQEVIKNKQCGYDVRKEGYPVDRNIHERGCLRAGEDWLEAHLISVAIGCVALLVLQGMELSK 259
            .|.|.|.:.|.|||||:|                                     |.|: :|...
  Rat   190 VRDPAEDVLNTQCGYDIR-------------------------------------LKLE-LEQQG 216

  Fly   260 IIYEKGCVQAGEEWMEHNLIIISATVIVVMFFQILGICFAQNLRADIYTQKSKW 313
            .||.||||...|:|::.|||:::..::.:...||.|||.||||.:||...|:.|
  Rat   217 SIYTKGCVGQFEKWLQDNLIVVAGVLVAIALLQICGICLAQNLVSDIEAVKANW 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp26A	NP_001097093.1	Tetraspannin	18..253	CDD:278750	95/235 (40%)
		DUF2207	<65..157	CDD:303056	38/91 (42%)
		TM4SF9_like_LEL	118..239	CDD:239412	51/120 (43%)
Tspan17	XP_006253692.1	TM4SF9_like_LEL	115..235	CDD:239412	64/161 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	214	1.000	Domainoid score	I2650
eggNOG	1	0.900	-	-		E1_KOG3882
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41762
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3319
OMA	1	1.010	-	-		QHG48585
OrthoDB	1	1.010	-	-		D1180379at2759
OrthoFinder	1	1.000	-	-		FOG0001766
OrthoInspector	1	1.000	-	-		otm46048
orthoMCL	1	0.900	-	-		OOG6_106312
Panther	1	1.100	-	-	O	PTHR19282
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X349
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880