Protein Alignment Tsp26A and TSPAN2

DIOPT Version :10

• Sequence 1: NP_001097093.1
• Gene: Tsp26A / 33838
• FlyBaseID: FBgn0031760
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_005716.2
• Gene: TSPAN2 / 10100
• HGNCID: 20659
• Length: 221
• Species: Homo sapiens
• Alignment Length: 733
• Identity: 129/733 - (17%)
• Similarity: 233/733 - (31%)
• Gaps: 248/733 - (33%)

  Fly    60 YVGPL-------PLSETIRPPEEIQAFRSVVFRDLLESEKAHVAELRGLSENFLEPLEGSQILSS 117
            |||.|       .|.|...|...:.:.|  |.||::.......|.:     ||.:|.:..:.|.:
Human    14 YVGDLHSDVTEAMLYEKFSPAGPVLSIR--VCRDMITRRSLGYAYV-----NFQQPADAERALDT 71

  Fly   118 NEYTQLMCNFLEVV-EMHEEFLQTLEDCNDRVGKVFLSNAPTM---KKIHQFYCA---------- 168
            ..:..:....:.:: ...:..|:     ...||.||:.|....   |.::..:.|
Human    72 MNFDVMKGKPIRIMWSQRDPSLR-----KSGVGNVFIKNLDKSIDNKALYDTFSAFGNILSCKVV 131

  Fly   169 -----------AHPRAIVIVDKFRDELN--------VFM-----EKQGAAKPGLLVLTTGLSKPF 209
                       .|.......||..:::|        ||:     .|:..|:.|      ..:|.|
Human   132 CDENGSKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKEREAELG------AKAKEF 190

  Fly   210 RRLDKYAAILQELERHMESGHPDRGDTQRSIAVYKDIASSCSATRRQKELELQIL---TGPVRGW 271
            ..:     .::.....::.|:            .|::.|...     |.|.::::   :|..:|:
Human   191 TNV-----YIKNFGEEVDDGN------------LKELFSQFG-----KTLSVKVMRDSSGKSKGF 233

  Fly   272 ------------------QGAELSTLGDIIHMGSVAVGPEHKDRYLVLFPQTLLILSVSQRMSAF 318
                              .|.|:|  |..|.:|......|.:......|.|.     ..:|:|
Human   234 GFVSYEKHEDANKAVEEMNGKEMS--GKAIFVGRAQKKVERQAELKRKFEQL-----KQERIS-- 289

  Fly   319 KYEGKLPLTGITVNRLEDT---DQLKNAFEISGTLIDRIVA-----------VC-QGPNEANRWV 368
            :|:|    ..:.:..|:||   ::|:..|...|::....|.           || ..|.||.:.|
Human   290 RYQG----VNLYIKNLDDTIDDEKLRREFSPFGSITSAKVMLEDGRSKGFGFVCFSSPEEATKAV 350

  Fly   369 ELLS-------------------PKSGAAEQGNTGAVDMKRNVSSSAVNIPQPPPHVSMLMSAA- 413
            ..::                   .|:....|.......|:...:|:.:|..||         ||
Human   351 TEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRALPASAILNQFQP---------AAG 406

  Fly   414 ----RAVPSEHGKNDANSTEQRTSKEGDAECNVRKECHSRERSYNSTDSDNESLKLPPA---SGP 471
                .|||...|:....:..|......    |.|.:...|.:.:..         :|.|   |||
Human   407 GYFVPAVPQAQGRPPYYTPNQLAQMRP----NPRWQQGGRPQGFQG---------MPSALRQSGP 458

  Fly   472 LSRP----MSPRSPCIGDSSNSSSTNSSKPTTSQAGVFPSGGDGLSHRPNISSNGAAARGSGKRV 532
              ||    ::|        :.::..:...|||:|....|:.      .||::...|.|..:.:.|
Human   459 --RPALRHLAP--------TGNAPASRGLPTTAQRVGVPTA------VPNLAPRAAVAAAAPRAV 507

  Fly   533 FSVLFELALSNWNITNLRPAPPLRPAFLSSVAVSGAGSAGGGTGGGRSATASITGSIGGAAASCV 597
            ....:..::.:       |.|.::|......||...|.            ..:|.|:..||
Human   508 APYKYASSVRS-------PHPAIQPLQAPQPAVHVQGQ------------EPLTASMLAAA---- 549

  Fly   598 SPTYEEDALVLRVIEAYCAAYQSTSRNTMHSGVEYDEMTPTLRQLFISVRQLQQDMAQVKLQIAE 662
            .|..::..|..|:....         .||||.:. .::|..|         |:.|.:::...:..
Human   550 PPQEQKQMLGERLFPLI---------QTMHSNLA-GKITGML---------LEIDNSELLHMLES 595

  Fly   663 ERSQRGHLQQ---VLMGH 677
            ..|.|..:.:   ||..|
Human   596 PESLRSKVDEAVAVLQAH 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp26A	NP_001097093.1	Tetraspanin	19..194	CDD:459767	31/178 (17%)
		TM4SF9_like_LEL	118..239	CDD:239412	20/158 (13%)
TSPAN2	NP_005716.2	Tetraspanin	11..212	CDD:459767	37/232 (16%)
		CD81_like_LEL	110..186	CDD:239404	11/81 (14%)