DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nalcn and para

DIOPT Version :9

Sequence 1:XP_036014574.1 Gene:Nalcn / 338370 MGIID:2444306 Length:1787 Species:Mus musculus
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2248 Identity:439/2248 - (19%)
Similarity:768/2248 - (34%) Gaps:709/2248 - (31%)


- Green bases have known domain annotations that are detailed below.


Mouse    20 RKQSS---RVEAQPVTDFGPDES-------LSDNADI--------LWINKPW-----------VH 55
            |.|.|   .:.:.|:.|..|..|       :|...||        :|:..|:           ||
  Fly    88 RLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVAIYILVH 152

Mouse    56 SLLRICAIISVISVC----MNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDS 116
            .|..:..|.:::..|    |.|..|.|          :.:.:...:||.|...|:..||.:....
  Fly   153 PLFSLFIITTILVNCILMIMPTTPTVE----------STEVIFTGIYTFESAVKVMARGFILCPF 207

Mouse   117 SYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFE---- 177
            :|::|.|...|..::...:|::.:.:..:|                   .:|.||:....:    
  Fly   208 TYLRDAWNWLDFVVIALAYVTMGIDLGNLA-------------------ALRTFRVLRALKTVAI 253

Mouse   178 LPRTR-ITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCVVN---DTKPGNVT--- 234
            :|..: |...:..|.:.:..|.|..:|.|.::.::|:|:: |..|..|:..   |...||:|   
  Fly   254 VPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDEN 318

Mouse   235 ----------WNS----LAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTS 285
                      |.|    ::.|  .|. .:....||...:.|  |:..| .....||:.|:..|.:
  Fly   319 WDYHNRNSSNWYSEDEGISFP--LCG-NISGAGQCDDDYVC--LQGFG-PNPNYGYTSFDSFGWA 377

Mouse   286 IFTVYEASSQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQ--- 347
            ..:.:...:|:.|..|....:.:...|...| ||.:||..::.:.|:.:|::..::.|::.:   
  Fly   378 FLSAFRLMTQDFWEDLYQLVLRAAGPWHMLF-FIVIIFLGSFYLVNLILAIVAMSYDELQKKAEE 441

Mouse   348 ----------------------------------------------------------------- 347
                                                                             
  Fly   442 EEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVG 506

Mouse   348 ---------------------------------------------------------FQQMWGTR 355
                                                                     |....|:|
  Fly   507 GEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSR 571

Mouse   356 SS-------------------------------------TTSTATTQM----------------- 366
            ||                                     ..|.|.|.|                 
  Fly   572 SSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLG 636

Mouse   367 ----------------FHEDAAGGWQLVAVDVNKPQGR----------------APACL------ 393
                            .|.|..||..::.|.....:.:                ...||      
  Fly   637 SRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKL 701

Mouse   394 --------------------------QKMMRSSVFHMFILSMVTVDVIVAA------------SN 420
                                      :.:...:|..|..: ||..|:|..|            |.
  Fly   702 DHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDV-MVLNDIIEQAAGRHSRASDRGVSV 765

Mouse   421 YY--------KGENFRRQ--------------------------------YDEF----------- 434
            ||        .|..|:.:                                :|.|           
  Fly   766 YYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVV 830

Mouse   435 ---YLA-----------------EVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTL 479
               ::|                 ...||..|.:||.:|:..:....|.....:.|:.::|..:.|
  Fly   831 NTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLL 895

Mouse   480 HVYPDLYH--SQFTYFQVLRVVRLIKISPALEDFVYKIFGPGK-KLGSLVVFTASLLIVMSAISL 541
            .:..:...  |....|::|||.:|.|..|.| :.:..|.|... .||:|......::.:.:.:.:
  Fly   896 ELGLEGVQGLSVLRSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGM 959

Mouse   542 QMF--CFVEELDR----------FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPLVAIY 594
            |:|  .:.:..||          ||.|..:||.:|::|..| |::.|...:........|    :
  Fly   960 QLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMYVGDVSCIP----F 1019

Mouse   595 FILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQM 659
            |:...:...|::|:||:|::|.|            ...|..:|.|                    
  Fly  1020 FLATVVIGNLVVLNLFLALLLSN------------FGSSSLSAPT-------------------- 1052

Mouse   660 VKISKLPSDFTVPKIRESF-----MKQFIDRQQQDTCCLFRILPSTSSSSCDNPKKPTAEDNKYI 719
                   :|....||.|:|     .|.::.|...|  |...|....::...|.|.........:|
  Fly  1053 -------ADNDTNKIAEAFNRIGRFKSWVKRNIAD--CFKLIRNKLTNQISDQPSGERTNQISWI 1108

Mouse   720 ----------------DQKLRKSVFSIRARNLLE---KETAVTKILRACTRQRMLSGSFEGQPAK 765
                            |.:|......|.|..|::   ||....::......:..:.|..:....|
  Fly  1109 WSEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPK 1173

Mouse   766 ERSILSVQHHIRQERRSLR-HGSNSQR----ISRGKSLETLTQDHSNTVRYRNAQREDSEIKMIQ 825
            :...|:  :....:..|:. :||:..|    .|...|.||:..:..     |:|.:||  :.:.:
  Fly  1174 KSKYLN--NATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEK-----RDASKED--LGLDE 1229

Mouse   826 EKKEQAEMKR---------KVQEEELRENHPYFDKPLFIVGREHRFRNFCRVVVRARFNASKTDP 881
            |..|:.|.:.         ...:|::.:.:|....|      :..::.|               |
  Fly  1230 ELDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCP------DSYYKKF---------------P 1273

Mouse   882 VTGAVKNTKYHQLYDLLGLVT-------YLDWVMITVTICSCISMMFES---PFRRVMHAPTLQI 936
            :.....::.:.|.:..|.|.|       |.:..:||:.:.|.:::..|.   |.|.::. ..|..
  Fly  1274 ILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQ-DILYY 1337

Mouse   937 AEYVFVIFMSIELNLKIMADG--LFFTPTAVIRDFGGVMDIFIYLVSLI-FLCWMPQNVPAESGA 998
            .:.:|.:...:|:.:|.:|.|  ::||......||      .|.:|||| |:.    ::....|.
  Fly  1338 MDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDF------VIVMVSLINFVA----SLVGAGGI 1392

Mouse   999 Q---LLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLA 1060
            |   .:..||.|||||....:..||.||..|......||.|.::.|...|:||..||||||||..
  Fly  1393 QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYF 1457

Mouse  1061 KCNDPNIIRREDCNG-------IFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVG 1118
            ||        ||.||       |...|...|:|.                 .|.|.. .|||:||
  Fly  1458 KC--------EDMNGTKLSHEIIPNRNACESENY-----------------TWVNSA-MNFDHVG 1496

Mouse  1119 NAMLALFEVLSLKGWVEV-RDVIIHR---VGPIH--GIYIHV----FVFLGCMIGLTLFVGVVIA 1173
            ||.|.||:|.:.|||::: .|.|..|   ..||.  .||:::    |:..|....|.||:||:|.
  Fly  1497 NAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIID 1561

Mouse  1174 NFNENKGTA------LLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFR--AKMYDITQHPFFKR 1230
            ||||.|..|      .:|.||:::.:...::...:||...|||   .:|  |.:::|.....|..
  Fly  1562 NFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRP---RWRPQAIVFEIVTDKKFDI 1623

Mouse  1231 TIALLV-LAQSVLLSVKWDVDDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGF---WQSRRNR 1291
            .|.|.: |....:...::|..|.....|..::.:|..||..|..:||.|:....|   |    |.
  Fly  1624 IIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPW----NL 1684

Mouse  1292 YDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTL-------KMLLLTVVVSMY 1349
            :|::|..|.::.:||. .::..| ::....:.|.|...: |:.:.|       :.||..:.:|:.
  Fly  1685 FDVVVVILSILGLVLS-DIIEKY-FVSPTLLRVVRVAKV-GRVLRLVKGAKGIRTLLFALAMSLP 1746

Mouse  1350 KSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDC 1414
            ..|.|.:.:||::..:|..|:..|..||....||...||.:.|:::.:||::.|...|:.:: |.
  Fly  1747 ALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVL-DA 1810

Mouse  1415 MVQPPFC-TPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQL- 1477
            ::....| .||....:..:||:....:.:..|:.||...|::|:.:|:|:||:|  .:||:.|. 
  Fly  1811 IINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYS--QATEDVQEG 1873

Mouse  1478 LSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEVDLDKDKLLFKHMCYEMERLHNGG 1542
            |:.:|...:..||...|.:....|...::...|.:|...|::....     |:....|:.....|
  Fly  1874 LTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPN-----KYKIISMDIPICRG 1933

Mouse  1543 DVTF-HDVLSML-----SYRSVDIRKSLQLEELLAREQLE-YTIEEEVAKQTIRMWLKKCLKRIR 1600
            |:.: .|:|..|     :.:...|.::.::.|:.||...| |   |.|:....|...:.|.:.|:
  Fly  1934 DLMYCVDILDALTKDFFARKGNPIEETGEIGEIAARPDTEGY---EPVSSTLWRQREEYCARLIQ 1995

Mouse  1601 AKQQQSCSIIHSLRESQEQ-ERSRLFLNPPSIETTQPSEDSNANSQDHSMQPETSSQQQLLSPTL 1664
                      |:.|:.:.: |....|         :|..|........:..|.........:|..
  Fly  1996 ----------HAWRKHKARGEGGGSF---------EPDTDHGDGGDPDAGDPAPDEATDGDAPAG 2041

Mouse  1665 SDR--GGSRQDAADTGKPQ-RKIGQWRLPSAAIAEKTAPVNKMSGYSQDPEREEEEV-----SKG 1721
            .|.  .|:.:.|||..:.. ...|:....:||.|...|.....:..|........:.     |.|
  Fly  2042 GDGSVNGTAEGAADADESNVNSPGEDAAAAAAAAAAAAAAGTTTAGSPGAGSAGRQTAVLVESDG 2106

Mouse  1722 FLAP---KPISHSVSSVNLRFGGRTTMKTVVCKMNPMP 1756
            |:..   |.:.||.|.       ..|.:|......|.|
  Fly  2107 FVTKNGHKVVIHSRSP-------SITSRTADVXARPRP 2137

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NalcnXP_036014574.1 Ion_trans 52..347 CDD:395416 66/335 (20%)
Ion_trans 399..619 CDD:395416 62/317 (20%)
Ion_trans 903..1177 CDD:395416 95/299 (32%)
Ion_trans 1225..1474 CDD:395416 65/260 (25%)
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 61/306 (20%)
Na_trans_cytopl 515..648 CDD:288761 9/132 (7%)
Ion_trans 835..1028 CDD:278921 41/198 (21%)
Na_trans_assoc 1054..1296 CDD:284034 47/273 (17%)
Ion_trans 1318..1571 CDD:278921 94/289 (33%)
Na_channel_gate 1561..1613 CDD:240441 16/54 (30%)
Ion_trans 1636..1871 CDD:278921 62/244 (25%)
GPHH 1880..1930 CDD:293510 9/54 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.840

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