Protein Alignment Kdm5 and JHD2

DIOPT Version :10

• Sequence 1: NP_523486.1
• Gene: Kdm5 / 33837
• FlyBaseID: FBgn0031759
• Length: 1838
• Species: Drosophila melanogaster
• Sequence 2: NP_012653.1
• Gene: JHD2 / 853583
• SGDID: S000003880
• Length: 728
• Species: Saccharomyces cerevisiae
• Alignment Length: 847
• Identity: 226/847 - (26%)
• Similarity: 370/847 - (43%)
• Gaps: 203/847 - (23%)

  Fly   160 ECPVFRPTTEEFKNPLAYISK--IRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRLNEL 222
            |.|...||.:|||||:.|:|.  |:.:..:.|:.|::||..:.||.::|::...|.||:|.|..|
Yeast     3 EIPALYPTEQEFKNPIDYLSNPHIKRLGVRYGMVKVVPPNGFCPPLSIDMENFTFQPRIQNLENL 67

  Fly   223 EAKTRVKLNFLDQIAKFWELQGSSLKIP--MVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKVA 285
            :.|.|.:|.|:.|:..|    ..|:|.|  ::.|:.   ||:
Yeast    68 DLKNRCRLFFMKQLNNF----KRSVKDPSKLILREP---YTI----------------------- 102

  Fly   286 NRMQYPSSKSVGATLKAHYERILHPFEVYTSGKVLGPTPTSSGSGSTPVKLEDGGGTDYKAHEIP 350
              ::|..|......||    :.::.::|::
Yeast   103 --VEYSDSTHASEILK----KKVYFYDVFS----------------------------------- 126

  Fly   351 TRQQIAPPNETNT------RRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEEFKRDLLSSF 409
               ::...|.|.|      ||..:|.:.:...|...:..|......|.:.. .||.|::.:.|.:
Yeast   127 ---ELIKDNRTLTDTTQSFRRKLKFRDISQLRGDISLWRTISKKFNVPIGL-LKEIFEKYIASYY 187

  Fly   410 NAVNSGGSPLATGTTANTRGASQKKGGEPPALIVDPLMKY------------------ICHICNR 456
            ..::|....:.|...|:.         .|.:|:.|....:                  .|.:|.:
Yeast   188 IFLHSLNENVHTALHADQ---------YPKSLLSDDEDDFDLGPDSNSGSDFEEDDDDACIVCRK 243

  Fly   457 GDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSKPQEAFGFEQAEREYTLQQF 521
            .:..:..:|||.||..:|.:||.|||..:|.|:|:|..|:|     ....:||.|...:|:|.:|
Yeast   244 TNDPKRTILCDSCDKPFHIYCLSPPLERVPSGDWICNTCIV-----GNGYYGFTQDTHDYSLPEF 303

  Fly   522 GQMADQFKQEYFRK------PVHLVPTEMVEREFWRIV-----SSIDEDVTVEYGADLHTMDHG- 574
                    |||.::      |...:..:.:|..||.:|     ||:   .||:||||:|....|
Yeast   304 --------QEYCKRQNSRLLPARKLSIDELEEMFWSLVTKNRRSSL---TTVKYGADIHNELPGQ 357

  Fly   575 -SGFPTKSSLYLLP----GDQ-----EYAESSWNLNNLPLLEDSILGHINADISGMNAPWMYVGM 629
             :||||:.   .:|    ||:     :|.:...||.|||:..:|:|.....:||||..||:|:|.
Yeast   358 ITGFPTRE---FIPKNINGDELIDYLKYCDHPMNLTNLPMAHNSLLPLFKRNISGMTIPWIYIGS 419

  Fly   630 CFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQPDLLHQLVTIM 694
            .|:.||||.||.::.|.||.|.|:||.||.:|.|...:|.:.:...:|:||..||||||||||::
Yeast   420 LFSTFCWHMEDQYTLSANYQHEGDPKVWYSIPESGCTKFNDLLNDMSPDLFIKQPDLLHQLVTLI 484

  Fly   695 ---NPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRECVNHY 756
               :|| ...:.:||::..|...|::||||:.||||||.||||.|||||....||..|...:..|
Yeast   485 SPYDPN-FKKSGIPVYKAVQKPNEYIITFPKCYHAGFNTGYNFNEAVNFTIDFWLPYGFGAITDY 548

  Fly   757 SMLRRFCVFSHDELVCKMALEPAKLTF----GIATACYIDMAEMVDTE-KKLRK--------SLL 808
            .:.::.|||...:|:..:..:..|.|.    .....||..:....:|| |::||        :||
Yeast   549 KLTQKACVFDMFDLMINVLDKYNKDTLLFNDAFVRQCYSSLIVFYNTELKRIRKIQAIVPRTTLL 613

  Fly   809 EWGVTRAERRAFELVNDDERH---CQECNTTCFLSAVACECN-DKLIVCLRHYTVLCGCAPEKHT 869
            |...        :..::||.:   |.:|.|.|.::.|..:.| |.:....||        .:.|.
Yeast   614 EVHT--------DPNDEDEEYDIFCSQCKTICSIAFVLRKNNYDSIRTYKRH--------KKNHL 662

  Fly   870 LIYRYTLDEMPLMLQKLKVKAHSFERWLSRCRDI---------VDAHTPTSVTLQELQELCKEAE 925
            .|.::.    .|.....||.....:.:|...:::         :|.....:.:|:::..|.|:..
Yeast   663 SIRQWN----ELSTTDSKVSILCTQDYLKSIQNLNNSDGEEPYIDDELYFTKSLKDIDSLIKQVG 723

  Fly   926 TK 927
            .|
Yeast   724 VK 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm5	NP_523486.1	JmjN	160..201	CDD:128818	16/42 (38%)
		ARID_JARID	226..312	CDD:350628	15/87 (17%)
		PHD1_Lid_like	450..495	CDD:277078	17/44 (39%)
		JmjC	624..740	CDD:396791	58/118 (49%)
		zf-C5HC2	830..882	CDD:460750	11/52 (21%)
		PLU-1	896..1231	CDD:462475	6/41 (15%)
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
JHD2	NP_012653.1	JmjN	3..46	CDD:128818	16/42 (38%)
		PHD_BAZ1A_like	237..282	CDD:277019	17/44 (39%)
		BAH	260..>320	CDD:470629	22/72 (31%)
		JmjC	414..532	CDD:396791	58/118 (49%)