Protein Alignment Kdm5 and PKDM7D

DIOPT Version :10

• Sequence 1: NP_523486.1
• Gene: Kdm5 / 33837
• FlyBaseID: FBgn0031759
• Length: 1838
• Species: Drosophila melanogaster
• Sequence 2: NP_172338.5
• Gene: PKDM7D / 837384
• AraportID: AT1G08620
• Length: 1223
• Species: Arabidopsis thaliana
• Alignment Length: 1360
• Identity: 331/1360 - (24%)
• Similarity: 492/1360 - (36%)
• Gaps: 501/1360 - (36%)

  Fly    55 GSESVK---KSNANDEPSTP-------------VTPAGATGSHTHAPPGI--------------- 88
            |:|.::   |.:::|.||.|             |.|  ||.|.....|.|
plant    16 GTELMRICVKEDSDDLPSVPPGFESYATFTLKRVVP--ATTSDKAKTPAIESVSATEQAKMEVES 78

  Fly    89 -----SPAVMERPMPSVPMNH----------ASSSVSASKKYHNSCPHPTPTPA-PTG------- 130
                 :.|:..||.    :||          |::..:||:....:|   ...|| |.|
plant    79 DEAKAARALRRRPW----INHSGCDDDGDCAANNDNAASQNPDQNC---DVKPALPKGVVRGCEE 136

  Fly   131 ----HKKSVHTQPHSSNKFDQGKNEEFHFDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIA 191
                .|.:....|      |:.:..:..     :.|||.|:.|||::.|.||:|||..|||.||.
plant   137 CKDCQKVTARWHP------DEARRPDLE-----DAPVFYPSEEEFEDTLNYIAKIRPEAEKYGIC 190

  Fly   192 KILPPATWSPPFAVDVDKL----RFVPRVQRLNELEAKTRVKLNFLDQIAKFWELQGSSLKIPMV 252
            :|:||.:|.||..:...::    :|..||||:::|:.::.:|
plant   191 RIVPPPSWKPPCPLKEKQVWEGSKFTTRVQRVDKLQNRSSMK----------------------- 232

  Fly   253 ERKALDLYTLHRIVQEEGGMEQTTKDRKWAKVANRMQYPSSKSVGATLKAHYERILHPFEVYTSG 317
                                       |.:|:.|:|
plant   233 ---------------------------KISKLPNQM----------------------------- 241

  Fly   318 KVLGPTPTSSGSGSTPVKLEDGGGTDYKAHEIPTRQQIAPPNETNTRRSKRFGNSNASC---GLS 379
                                                          |:.||      .|   |:.
plant   242 ----------------------------------------------RKKKR------KCMKMGMD 254

  Fly   380 GVTPTTKPSAGVFVKTETKEEFKRDLLSSFNAVNSGGSPLATGTTANTRGASQKKGGEPPALIVD 444
            .||                              |..|.|.:..|..|
plant   255 SVT------------------------------NGMGDPCSASTGMN------------------ 271

  Fly   445 PLMKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSKPQEAFGF 509
                                                                      ..|.|||
plant   272 ----------------------------------------------------------ELETFGF 278

  Fly   510 EQAEREYTLQQFGQMADQFKQEYFRK-------------------PVHLVPTEMVEREFWRIVSS 555
            |... .:||:.|.:.||:||.:||:|                   |.    .|.||.|:||||..
plant   279 EPGP-GFTLKDFQKYADEFKAQYFKKSETSTDDKCKVDNSIDCWEPA----LEDVEGEYWRIVDK 338

  Fly   556 IDEDVTVEYGADLHTMDHGSGFPTKSSLY-LLPGDQEYAESSWNLNNLPLLEDSILGHINADISG 619
            ..|::.|.|||||.|...|||||..||.: ....:.:||:|.|||||.|.|..|:|.:..:||||
plant   339 ATEEIEVLYGADLETGVFGSGFPKISSSHNASSSEDKYAKSGWNLNNFPRLPGSLLKYEGSDISG 403

  Fly   620 MNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQP 684
            :..||:|:||||::||||.|||..||:||:|||.||.||||.|..|.:.||.|::..|:||..||
plant   404 VLVPWLYIGMCFSSFCWHVEDHHLYSLNYMHWGAPKLWYGVGGKDAVKLEEAMRKHLPDLFEEQP 468

  Fly   685 DLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMG 749
            ||||:|||.::|:.|....|||.|..|||||||:|||||||||||.|:|.|||||.||.|||..|
plant   469 DLLHKLVTQLSPSKLKTAGVPVHRCVQHAGEFVLTFPRAYHAGFNSGFNCAEAVNVAPVDWLPHG 533

  Fly   750 RECVNHYSMLRRFCVFSHDELVCKMALEPAKLTF----------------------GIATACYID 792
            :..:..|....|....|||:|:...|.|..|..:                      ||...   .
plant   534 QIAIELYCQQGRKTSISHDKLLLGAAREVVKADWELNLLRKNTVDNLRWKAFSAKDGILAK---T 595

  Fly   793 MAEMVDTEKKLRKSLLEWGVTRAERRAFELVNDDERHCQECNTTCFLSAVACECNDKLIVCLRHY 857
            :...:|.|:..|:.|....:.......|:..|  ||.|..|.....|||..|.|:.:...||.|.
plant   596 LKARIDMERTRREFLCNSSLALKMHSNFDATN--ERECCICFFDLHLSAAGCRCSPEKYSCLTHV 658

  Fly   858 TVLCGCAPEKHTLIYRYTLDEMPLMLQKLKVKAHSFERW------LSRCRDI------VDAH--- 907
            ..||.|.......::||.:||:.::::.::.|..|..||      |:...|:      :|..
plant   659 KELCSCPWVTKYFLFRYDIDELNVLVEAVEGKLSSVYRWARQDLGLALSTDVSGSKMEIDEEGKV 723

  Fly   908 ----TP--TSVTLQELQ------ELCKEAE-TKKFPSSLLIDRLNAAAVEAEKCVTVIQQLGINK 959
                ||  |:::.::||      |:.||.| |.|.....|:.:.....:.:..|:..:::   ..
plant   724 HKDPTPQTTALSGKDLQLKVTSKEVSKELEKTSKLSHVNLLLKEKEEQITSSHCMKPVKE---ET 785

  Fly   960 VRTRSDHNQEAAQYK----LTMEELELF-----VQEIDNLCCIIDE---------GASVRELLVL 1006
            |...||.|..|.|..    :.|..::..     .|.:.|...::.:         |:..|:.:..
plant   786 VCDSSDPNVSACQPSEGGIICMTAVKSASGKKNSQSLPNDVILLSDDEYDIPRKRGSVRRDAISS 850

  Fly  1007 GKQFVERSESQLQLSLESLEESELETLINEGSSLR-----IELQQLDLLQKRLKQ--------CK 1058
            ||:...|......|:||:..:........||.|||     |.|...|  ||.:::        .:
plant   851 GKKLEIRERPTHVLALEASAKIAAPICQREGDSLRDTRNTISLPTND--QKTMRRDVPSSTSHAE 913

  Fly  1059 WYKRSQGLRE-------TSS----KLTYQDVKNLLHIAAADL---------DPTDPYVDKEMRKL 1103
            ....:.||.:       |:|    |.|....||...:|..|:         .|:....:...|.:
plant   914 VNAEATGLTQDICNRMATNSHGGGKPTSCKSKNSGGLAIVDVVDGTRSSSGTPSCSQNNSPDRFI 978

  Fly  1104 QQIGADIEAWESQAAKYFRRLTQQHELGEIEQFLKSASDINGQVPSHGLLKDALRKAREWL--RA 1166
            :|.|..|       ||..||:                 :.|.:..|:|    .:...:.|.  ||
plant   979 RQKGPRI-------AKVVRRI-----------------NCNVEPLSYG----CVLSGKSWCSRRA 1015

  Fly  1167 VEQLQQNNHVTY---------CHTLEAMIERGLNIPIQLEEL----SRMQGHLNSAHQWK 1213
            :......:.|.|         |..:..:::.|.|.|:.:..|    |.:..|::....|:
plant  1016 IFPKGFRSRVKYINILDPTNMCFYISEILDAGRNSPLFMVYLESNPSEVFVHMSPTRCWE 1075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm5	NP_523486.1	JmjN	160..201	CDD:128818	22/40 (55%)
		ARID_JARID	226..312	CDD:350628	5/85 (6%)
		PHD1_Lid_like	450..495	CDD:277078	0/44 (0%)
		JmjC	624..740	CDD:396791	73/115 (63%)
		zf-C5HC2	830..882	CDD:460750	17/51 (33%)
		PLU-1	896..1231	CDD:462475	79/412 (19%)
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
PKDM7D	NP_172338.5	JmjN	161..193	CDD:460542	18/31 (58%)
		JmjC	408..524	CDD:396791	73/115 (63%)
		zf-C5HC2	631..683	CDD:460750	17/51 (33%)
		FYRN	1002..1046	CDD:128814	7/47 (15%)
		FYRC	1052..1146	CDD:197781	4/24 (17%)