DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and KDM5D

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_001140177.1	Gene:	KDM5D / 8284	HGNCID:	11115	Length:	1570	Species:	Homo sapiens

Alignment Length:	1660	Identity:	680/1660 - (40%)
Similarity:	931/1660 - (56%)	Gaps:	255/1660 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 FDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRL 219
            |..|||||||.|:..||::||.||:|||.||||.||.||.|||.|.|||||:||..||.||||||
Human     8 FLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRVQRL 72

  Fly   220 NELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKV 284
            |||||:||||||:|||||||||:||||||||.||||.||||:|.:||.||||.|...|||:||:|
Human    73 NELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVIEEGGYEAICKDRRWARV 137

  Fly   285 ANRMQYPSSKSVGATLKAHYERILHPFEVYTSGKVLGPTPTSSGSGSTPVKLEDGGGTDYKAHEI 349
            |.|:.||..|::|:.|::|||||::|:|::.||  ......::......||     ..:||.|.|
Human   138 AQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSG--ANHVQCNTHPFDNEVK-----DKEYKPHSI 195

  Fly   350 PTRQQIAPPN-ETNTRRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEEF-KRDLLSSFNAV 412
            |.||.:.|.. .:.:||:||            :.|..:|         |:|:. |...|......
Human   196 PLRQSVQPSKFSSYSRRAKR------------LQPDPEP---------TEEDIEKHPELKKLQIY 239

  Fly   413 NSGGSPLATGTTANTRGAS-QKKGGEPPALIV---------------------DPLMK------- 448
            ..|...:..|..|..:..: .||...||.:.|                     :|..|
Human   240 GPGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTLLKQHLSLEPCTKTTMQLRK 304

  Fly   449 ----------YICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSKP 503
                      |||.:|:|||.::.:|.||||||:||.|||||||..||:|.|.||:|::.|..:|
Human   305 NHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPKCILAECKQP 369

  Fly   504 QEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFWRIVSSIDEDVTVEYGADL 568
            .||||||||.:||:||.||:|||.||.:||..|||:||||:||:||||:||||:||||||||||:
Human   370 PEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVTVEYGADI 434

  Fly   569 HTMDHGSGFPTKSSLY-------------------------LLP-------GDQEYAESSWNLNN 601
            |:.:.|||||..:|..                         :||       |.||||.|.||||.
Human   435 HSKEFGSGFPVSNSKQNLSPEEKRQSLTVLTRLISSFWAQAVLPPWPPKVLGLQEYATSGWNLNV 499

  Fly   602 LPLLEDSILGHINADISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAE 666
            :|:|:.|:|.|||||||||..||:||||.|:|||||.|||||||||||||||||||||||...||
Human   500 MPVLDQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAE 564

  Fly   667 QFEETMKQAAPELFSSQPDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQG 731
            ..||.||...||||.|||||||||||:||||.||::.|||.||:|.|||||||||||||:|||||
Human   565 HLEEVMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQG 629

  Fly   732 YNFAEAVNFAPADWLKMGRECVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAEM 796
            |||||||||..||||..||:|:.||..|||:|||||:||:||||..|..|...:|.|.:.:|..|
Human   630 YNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEMFIM 694

  Fly   797 VDTEKKLRKSLLEWGVTRAERRAFELVNDDERHCQECNTTCFLSAVAC-ECNDKLIVCLRHYTVL 860
            |..|::|||:|||.|||.|||.||||:.||||.|.:|.|||||||:|| :|.|.| |||.|...|
Human   695 VQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGL-VCLSHINDL 758

  Fly   861 CGCAPEKHTLIYRYTLDEMPLMLQKLKVKAHSFERWLSRCRDIVDAHTPTSVTLQELQELCKEAE 925
            |.|:..:..|.|||||||:|.||.|||::|.||:.|.::.|..::.......:.:||:.|..||.
Human   759 CKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVEDGRKRSFEELRALESEAR 823

  Fly   926 TKKFPSSLLIDRLNAAAVEAEKCVTVIQQLGINKVRTRSDHNQEAAQYKLTMEELELFVQEIDNL 990
            .::||:|.|:.||.....|.|.|:..:..|...:| .|.|..|      ||:.||.:.::::.:|
Human   824 ERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQV-ARMDTPQ------LTLTELRVLLEQMGSL 881

  Fly   991 CCIIDEGASVRELLVLGKQFVERSESQLQLSLESLEESE--LETLINEGSSLRIELQQLDLLQKR 1053
            .|.:.:...|:::|    :.||..:::.:.:|.:|..|.  |.:|:..|..|.:|:.:...||::
Human   882 PCAMHQIGDVKDVL----EQVEAYQAEAREALATLPSSPGLLRSLLERGQQLGVEVPEAHQLQQQ 942

  Fly  1054 LKQCKWYKR-SQGLRETSSKLTYQDVKNLLHIAAADLDPTDPYVDKEMRKLQQIGADIEAWESQA 1117
            ::|.:|... .|.|..::.:.:...::.||.:.|.  ..:.|.|||...:||::....|.|| :.
Human   943 VEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAK--IASSPSVDKARAELQELLTIAERWE-EK 1004

  Fly  1118 AKYFRRLTQQHELGEIEQFLKSASDINGQVPSHGLLKDALRKAREWLRAVEQLQQNNHVTYCHTL 1182
            |.:.....|:|....:|..::...:|...:|:...||:||.||:.|:..|:::|..:|......|
Human  1005 AHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQAWIADVDEIQNGDHYPCLDDL 1069

  Fly  1183 EAMIERGLNIPIQLEELSRMQGHLNSAHQWKDNTACAFLKKGTFYTLLEVLMPRSDAINIDSDLK 1247
            |.::..|.::|:.||||.:::..:.:||.|::..:..||||.:.|||||||.|.:|| ..||..:
Human  1070 EGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADA-GSDSTKR 1133

  Fly  1248 PRFQDDFL---------------KEKNPAEIVASFKHAEEQELLDMRELRRQNMNK-NPMR---- 1292
            .|:.:..|               ..::|..::.:||..|::|...:.:|||.|..| :|:.
Human  1134 SRWMEKALGLYQCDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLAPSLM 1198

  Fly  1293 ----DMFCLCKSEFRNL-MFNCQLCRDWFHEDCV--------PPPSATNQNGIVNGGSGPGTNRP 1344
                ...|:|......: :..|.||:||||..||        |.||.|:.              |
Human  1199 ASSPTSICVCGQVPAGVGVLQCDLCQDWFHGQCVSVPHLLTSPKPSLTSS--------------P 1249

  Fly  1345 ---------KWLCPSCVRSKRPRLETILPLLVQLQQLPIRLPEDEALRCLAERAMNWQDRARKAL 1400
                     |:|||.|:||:||||||||.|||.||:||:||||.|||:||.|||:.|||||||||
Human  1250 LLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAIGWQDRARKAL 1314

  Fly  1401 SSPDVSA--AQEAIMAQQQQKRRSEGGAGVGNISSPRKPRRRGS---LTKEASGSTESDADDDDD 1460
            :|.||:|  .|.|.:.||.|.:.....|.|...::...|.|.||   ::| ..|..|:.
Human  1315 ASEDVTALLRQLAELRQQLQAKPRPEEASVYTSATACDPIREGSGNNISK-VQGLLENG------ 1372

  Fly  1461 EDECRLRIVEDNFSNDEDEPRTAPATST---VNSDLLKLLSDSEIE-------NLLDLMMEGDLL 1515
                      |:.::.|:   .||...:   :.|.||..|:...:|       .|.:||||||||
Human  1373 ----------DSVTSPEN---MAPGKGSDLELLSSLLPQLTGPVLELPEAIRAPLEELMMEGDLL 1424

  Fly  1516 EVSLDETQELWRILET-MPPTLLQAEAMERVVQYMQRQRQQHTNPLPTSGAEDSNDSLMVQNSPN 1579
            ||:|||...:|::|:. .||.|      :|:...::.::.:|
Human  1425 EVTLDENHSIWQLLQAGQPPDL------DRIRTLLELEKFEH----------------------- 1460

  Fly  1580 SNSNSGGATGSASNSGRNKKRRSNDTGGN--SAVPRKKQSTPKQTPGKKGSAAAARKSDAKASPA 1642
                .|..|.|.:.. |.::|:..|.|.|  :.|.::.||...::.|.........:...:.:..
Human  1461 ----QGSRTRSRALE-RRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADR 1520

  Fly  1643 AS--TTPGADADAENKQANGGNTNSSTGSGGGNSA 1675
            .:  .||..|.....|    ||.||......|:||
Human  1521 ENMFLTPSTDHSPFLK----GNQNSLQHKDSGSSA 1551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	27/40 (68%)
		ARID	227..312	CDD:198082	57/84 (68%)
		PHD1_Lid_like	450..495	CDD:277078	28/44 (64%)
		JmjC	624..740	CDD:202224	92/115 (80%)
		zf-C5HC2	830..882	CDD:280996	30/52 (58%)
		PLU-1	896..1229	CDD:285609	89/335 (27%)
		PHD2_KDM5A	1295..1351	CDD:277079	20/73 (27%)
		PHD3_KDM5A_like	1755..1805	CDD:277083
KDM5D	NP_001140177.1	JmjN	13..54	CDD:128818	27/40 (68%)
		BRIGHT	80..170	CDD:128777	58/89 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	192..228		14/56 (25%)
		PHD1_KDM5C_5D	316..361	CDD:277077	28/44 (64%)
		JmjC	522..638	CDD:202224	92/115 (80%)
		zf-C5HC2	728..780	CDD:280996	30/52 (58%)
		PLU-1	793..1116	CDD:285609	89/336 (26%)
		PHD2_KDM5C_5D	1205..1265	CDD:277081	20/73 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1460..1552		24/124 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151682
Domainoid	1	1.000	221	1.000	Domainoid score	I2615
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1252	1.000	Inparanoid score	I176
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53001
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	1	1.000	-	-		FOG0000761
OrthoInspector	1	1.000	-	-		otm40656
orthoMCL	1	0.900	-	-		OOG6_100617
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X397
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870