DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and JMJ14

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_193773.2	Gene:	JMJ14 / 827788	AraportID:	AT4G20400	Length:	954	Species:	Arabidopsis thaliana

Alignment Length:	1236	Identity:	311/1236 - (25%)
Similarity:	458/1236 - (37%)	Gaps:	452/1236 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 ECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKL----RFVPRVQRLN 220
            :.|:|.||.|:|.:||.||.|:||.||..||.:|:||..|.||..:...|:    :|..|:|.::
plant    55 DAPIFYPTNEDFDDPLGYIEKLRSKAESYGICRIVPPVAWRPPCPLKEKKIWENSKFPTRIQFID 119

  Fly   221 ELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKVA 285
            .|:.:..:|               .|.|                           ||.||..:::
plant   120 LLQNREPIK---------------KSTK---------------------------TKKRKRRRIS 142

  Fly   286 NRMQYPSSKSVGATLKAHYERILHPFEVYTSGKVLGPTPTSSGSGSTPVKLEDGGGTDYKAHEIP 350
                           |..|
plant   143 ---------------KIGY---------------------------------------------- 146

  Fly   351 TRQQIAPPNETNTRRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEEFKRDLLSSFNAVNSG 415
                        |||                                    |||
plant   147 ------------TRR------------------------------------KRD----------- 152

  Fly   416 GSPLATGTTANTRGASQKKGGEPPALIVDPLMKYICHICNRGDVEESMLLCDGCDDSYHTFCLLP 480
                 :|....:.|:|..:|
plant   153 -----SGCDTASSGSSDSEG--------------------------------------------- 167

  Fly   481 PLTSIPKGEWLCPRCVVEEVSKPQEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVH------- 538
                                     .||| |...::||::|.:..:.||:.||:...|
plant   168 -------------------------KFGF-QTGPDFTLEEFQKYDEYFKECYFQSEDHPGSKASE 206

  Fly   539 ---LVP-TEMVEREFWRIVSSIDEDVTVEYGADLHTMDHGSGFPTKSSLYLLPGDQEYAESSWNL 599
               ..| .:.:|.|:||||....::|.|.|||||.|...|||||.....|.:....:|::..|||
plant   207 NKKFKPKVKDLEGEYWRIVEQATDEVEVYYGADLETKKFGSGFPKYKPGYPISEADQYSQCGWNL 271

  Fly   600 NNLPLLEDSILGHINADISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSC 664
            |||..|..|:|...:.||||:..||:||||||:.||||.|||..||:||||.|:||.|||:||:.
plant   272 NNLSRLPGSVLAFESCDISGVIVPWLYVGMCFSTFCWHVEDHHLYSMNYLHTGDPKVWYGIPGNH 336

  Fly   665 AEQFEETMKQAAPELFSSQPDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFN 729
            ||.||..||:..|:||..||||||||||.::|.||....|||:|..|.:|||::|||:|||:|||
plant   337 AESFENVMKKRLPDLFEEQPDLLHQLVTQLSPRILKEEGVPVYRAVQRSGEFILTFPKAYHSGFN 401

  Fly   730 QGYNFAEAVNFAPADWLKMGRECVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMA 794
            .|:|.|||||.||.|||..|:..|..||..||....|||:|:...|:|        ||.|..:::
plant   402 CGFNCAEAVNVAPVDWLVHGQNAVEGYSKQRRKSSLSHDKLLLGAAME--------ATYCLWELS 458

  Fly   795 EMVDTEKKLRKSLLEWG--------VTRAERRAFELV---------------------NDDERHC 830
                ..||....:..|.        :|:|.::..::.                     |..||.|
plant   459 ----LSKKKTPVIARWKRVCSEDGLLTKAVKKRVQMEEERLNHLQDGFSLRKMEGDFDNKREREC 519

  Fly   831 QECNTTCFLSAVACECNDKLIVCLRHYTVLCGCAPEKHTLIYRYTLDEMPLMLQKLKVKAHSFER 895
            ..|.....:||.:|:|:.....||.|...||.|..:...::.|:||||:..:::.|:....:.:.
plant   520 FLCFYDLHMSASSCKCSPNRFACLIHAKDLCSCESKDRYILIRHTLDELWALVRALEGDLDAIDL 584

  Fly   896 WLSRCRDIVDAHTPTSVTLQELQELCKEAETKKFPSSLLIDRLNAAAVEAEKCVTVIQQLGINKV 960
            |.|:|||                         ::||.....| ..|.:::..|   |:..|.:||
plant   585 WASKCRD-------------------------QYPSQHPRAR-EYAYLKSAPC---IKSRGSSKV 620

  Fly   961 RTRSDHN----QEAAQYKLTM-EELEL------------FVQEIDNLCCIIDEGASVRELLVLGK 1008
            :.|..:|    .|..|..||. :|::|            ...|.:::..|.|:.|.....|.:|.
plant   621 QQREQNNLQLVSERLQSDLTSNKEVQLKQDGDSDVNRHGHESERNHVHGITDKSAVTDVKLGVGG 685

  Fly  1009 QFVERS---ESQLQLSLESLEESEL------------ETLINEGSSLRIE-LQQLDLLQKRLKQC 1057
            :|.|:.   |||...|:..:..|||            :.......||.:| |....|:.|:|...
plant   686 KFDEKKISVESQNPHSVSDVGCSELAKKVDGCLGGKDQNAATNRLSLSVELLSSGSLVVKKLWCS 750

  Fly  1058 KWYKRSQGLRETSSKLTYQDVKNLLHIAAADLD---------------PTDPYVDKEMRKLQQIG 1107
            |.....:|.:.....|:..|..||.:..:..||               ||:.:.:
plant   751 KQAIYPKGFKSRVKFLSVLDPTNLTNYISEVLDAGLLGPLFRVSVEDYPTENFSN---------- 805

  Fly  1108 ADIEAWESQAAKYFRRLTQQHELGEIEQ---------FLKSASDINGQVPSHGLLKDALRKAREW 1163
                   ..|.|.::.:||:.:|..|::         .|:....||| :...|.|...:.|..|.
plant   806 -------VSAEKCWQMVTQRLKLEIIKKCDQPVSSLTSLQPLESING-LEMFGFLSPHVIKVVEA 862

  Fly  1164 LRAVEQLQQ--NNHVTYCHTLEAMIERGLNIPIQLEELSRMQGHLNSAHQWKDNTACAFLKKGTF 1226
            |....||::  |.........|         ||:..|              ||:|     :||
plant   863 LDPKHQLEEYWNQKAVKLFGAE---------PIKEGE--------------KDDT-----EKG-- 897

  Fly  1227 YTLLEVLMPRSDAINIDSDLKPRFQDDFLKEKNPAEIV-------ASFKHAEEQE----LLDMRE 1280
                    ..||. ::|.|  .|.....||:..|.|:|       ...::.|.:|    |:|..|
plant   898 --------GASDP-SLDRD--TRLLRGLLKKATPEELVMMHGLLCGETRNTELKEELSTLVDKME 951

  Fly  1281 L 1281
            :
plant   952 I 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	21/40 (53%)
		ARID	227..312	CDD:198082	9/84 (11%)
		PHD1_Lid_like	450..495	CDD:277078	0/44 (0%)
		JmjC	624..740	CDD:202224	73/115 (63%)
		zf-C5HC2	830..882	CDD:280996	17/51 (33%)
		PLU-1	896..1229	CDD:285609	81/391 (21%)
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
JMJ14	NP_193773.2	JmjN	56..96	CDD:128818	21/39 (54%)
		JmjC	296..412	CDD:202224	73/115 (63%)
		zf-C5HC2	519..571	CDD:280996	17/51 (33%)
		FYRN	743..784	CDD:128814	9/40 (23%)
		FYRC	790..876	CDD:197781	20/103 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	175	1.000	Domainoid score	I1097
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100617
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X397
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.820