DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and KDM5C

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_004178.2	Gene:	KDM5C / 8242	HGNCID:	11114	Length:	1560	Species:	Homo sapiens

Alignment Length:	1660	Identity:	695/1660 - (41%)
Similarity:	949/1660 - (57%)	Gaps:	257/1660 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 FDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRL 219
            |..|||||||.|:..||::||.||:|||.||||.||.||.|||.|.|||||:||..||.||:|||
Human     8 FLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRL 72

  Fly   220 NELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKV 284
            |||||:||||||:|||||||||:||||||||.|||:.||||:|.:||.||||.|...|||:||:|
Human    73 NELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVVEEGGYEAICKDRRWARV 137

  Fly   285 ANRMQYPSSKSVGATLKAHYERILHPFEVYTSGKVLGPTPTSSGSGSTPVKLEDGGGTDYKAHEI 349
            |.|:.||..|::|:.|::|||||::|:|:|.||..|....|.........|       :||.|.|
Human   138 AQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRPFDNEEKDK-------EYKPHSI 195

  Fly   350 PTRQQIAPPNETNT--RRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEEF-KRDLLSSFNA 411
            |.||.: .|::.|:  ||:||            :.|..:|         |:|:. |...|.....
Human   196 PLRQSV-QPSKFNSYGRRAKR------------LQPDPEP---------TEEDIEKNPELKKLQI 238

  Fly   412 VNSGGSPLATGTTA--NTRGASQKKGGE-PPALIV-----------------------------D 444
            ..:|...:..|..|  .|.....|:|.| ||.::|                             :
Human   239 YGAGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSHSPE 303

  Fly   445 PLMK-----------------YICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLC 492
            |..|                 |:|.:|:|||.::.:||||||||:||.|||||||..||||.|.|
Human   304 PCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRC 368

  Fly   493 PRCVVEEVSKPQEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFWRIVSSID 557
            |:||:.|..:|.||||||||.||||||.||:|||.||.:||..|||:||||:||:||||:|:||:
Human   369 PKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIE 433

  Fly   558 EDVTVEYGADLHTMDHGSGFP-TKSSLYLLPGDQEYAESSWNLNNLPLLEDSILGHINADISGMN 621
            ||||||||||:|:.:.||||| :.|..:|.|.::|||.|.||||.:|:||.|:|.|||||||||.
Human   434 EDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMK 498

  Fly   622 APWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQPDL 686
            .||:||||.|:|||||.|||||||||||||||||||||||...||..||.||:..||||.|||||
Human   499 VPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDL 563

  Fly   687 LHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRE 751
            ||||||:||||.||::.|||.||:|.|||||||||||||:||||||||||||||..||||..||:
Human   564 LHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQ 628

  Fly   752 CVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAEMVDTEKKLRKSLLEWGVTRAE 816
            |:.||..|||:|||||:||:||||..|.||...:|.|.:.:|..||..|::|||:|||.|:|.||
Human   629 CIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEKGITEAE 693

  Fly   817 RRAFELVNDDERHCQECNTTCFLSAVAC-ECNDKLIVCLRHYTVLCGCAPEKHTLIYRYTLDEMP 880
            |.||||:.||||.|.:|.|||||||:|| :|.|.| |||.|...||.|:..:..|.|||||||:|
Human   694 REAFELLPDDERQCIKCKTTCFLSALACYDCPDGL-VCLSHINDLCKCSSSRQYLRYRYTLDELP 757

  Fly   881 LMLQKLKVKAHSFERWLSRCRDIVDAHTPTSVTLQELQELCKEAETKKFPSSLLIDRLNAAAVEA 945
            .||.||||:|.||:.|.::.|..::.......:|:||:.|..||..::||:|.|:.:|.....||
Human   758 AMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQQLKNCLSEA 822

  Fly   946 EKCVTVIQQLGINKVRTRSDHNQEAAQYKLTMEELELFVQEIDNLCCIIDEGASVRELLVLGKQF 1010
            |.||:  :.||:...:....|  ..|..::|:.||..|:.:::||.|.:.:...|:.:|    :.
Human   823 EACVS--RALGLVSGQEAGPH--RVAGLQMTLTELRAFLDQMNNLPCAMHQIGDVKGVL----EQ 879

  Fly  1011 VERSESQLQLSLESLEESE--LETLINEGSSLRIELQQLDLLQKRLKQCKW---YKRSQGLRETS 1070
            ||..:::.:.:|.||..|.  |::|:..|..|.:|:.:...||::::|.:|   .||:  |..::
Human   880 VEAYQAEAREALASLPSSPGLLQSLLERGRQLGVEVPEAQQLQRQVEQARWLDEVKRT--LAPSA 942

  Fly  1071 SKLTYQDVKNLLHIAAADLDPTDPYVDKEMRKLQQIGADIEAWESQAAKYFRRLTQQHELGEIEQ 1135
            .:.|...::.|| :|.|.:.|: |.|||...:||::....|.|| :.|.......|:|....:|.
Human   943 RRGTLAVMRGLL-VAGASVAPS-PAVDKAQAELQELLTIAERWE-EKAHLCLEARQKHPPATLEA 1004

  Fly  1136 FLKSASDINGQVPSHGLLKDALRKAREWLRAVEQLQQNNHVTYCHTLEAMIERGLNIPIQLEELS 1200
            .::.|.:|...:|:...||:||.|||.|:..|:::|..:|......||.::..|.::|:.||||.
Human  1005 IIREAENIPVHLPNIQALKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELR 1069

  Fly  1201 RMQGHLNSAHQWKDNTACAFLKKGTFYTLLEVLMPRSDAINIDSDLKPRFQDDFLKE-------- 1257
            :::..:.:||.|::..:..||||.:.|||||||.|.:|| ..||..:.|:.:   ||
Human  1070 QLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADA-GSDSTKRSRWME---KELGLYKSDT 1130

  Fly  1258 ----------KNPAEIVASFKHAEEQELLDMRELRRQNMNK-NPMRD--------MFCLCKSEFR 1303
                      ::|..::.:||..|::|...:.:|||.|..| :|:..        ..|:|.....
Human  1131 ELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASSSTASSTTSICVCGQVLA 1195

  Fly  1304 NL-MFNCQLCRDWFHEDCVPPP---SATNQNGIVNGGSGPGTNRP---------KWLCPSCVRSK 1355
            .. ...|.||:||||..||..|   |:...|         .|:.|         |:|||.|:||:
Human  1196 GAGALQCDLCQDWFHGRCVSVPRLLSSPRPN---------PTSSPLLAWWEWDTKFLCPLCMRSR 1251

  Fly  1356 RPRLETILPLLVQLQQLPIRLPEDEALRCLAERAMNWQDRARKALSSPDVSAAQEAIMAQQQQKR 1420
            ||||||||.|||.||:||:||||.|||:||.|||::||.|||:||:|.||:|.. ..:|:.:|:.
Human  1252 RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALL-GRLAELRQRL 1315

  Fly  1421 RSEGGAGVGNISSPRKPRR-----RGSLTKEASGSTESDADDDDDEDECRLRIVEDNFSNDEDEP 1480
            ::|        ..|.:|..     .....:|.||           :|..:::.:.:|..:.....
Human  1316 QAE--------PRPEEPPNYPAAPASDPLREGSG-----------KDMPKVQGLLENGDSVTSPE 1361

  Fly  1481 RTAPATSTVNSDLLKLLS--------------DSEIENLLDLMMEGDLLEVSLDETQELWRILET 1531
            :.||...:...| |:|||              ::....|.:||||||||||:|||...:|::|:.
Human  1362 KVAPEEGSGKRD-LELLSSLLPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQA 1425

  Fly  1532 -MPP------TLLQAEAMERVVQYMQRQRQQHTNPLPTSGAEDSNDSLMVQNSPNSNSNSGGATG 1589
             .||      |||:.|..||                                      :...|.|
Human  1426 GQPPDLERIRTLLELEKAER--------------------------------------HGSRARG 1452

  Fly  1590 SASNSGRNKKRRSNDTGGNSAVPRKKQSTPKQTPGKKGSAAAARKSD-------AKASPAASTTP 1647
            .|.   ..::||..|.||....|.:::..||:.......|...::.:       .:..||...|.
Human  1453 RAL---ERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTT 1514

  Fly  1648 GADADAENKQANGGNTNSSTGSGGGNSA---TTTP 1679
            |:.:..||:  ||  ...:.|:..|.||   |.||
Human  1515 GSPSTQENQ--NG--LEPAEGTTSGPSAPFSTLTP 1545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	27/40 (68%)
		ARID	227..312	CDD:198082	56/84 (67%)
		PHD1_Lid_like	450..495	CDD:277078	29/44 (66%)
		JmjC	624..740	CDD:202224	92/115 (80%)
		zf-C5HC2	830..882	CDD:280996	30/52 (58%)
		PLU-1	896..1229	CDD:285609	98/337 (29%)
		PHD2_KDM5A	1295..1351	CDD:277079	20/68 (29%)
		PHD3_KDM5A_like	1755..1805	CDD:277083
KDM5C	NP_004178.2	JmjN	13..54	CDD:128818	27/40 (68%)
		BRIGHT	80..170	CDD:128777	58/89 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..227		12/51 (24%)
		PHD1_KDM5C_5D	326..371	CDD:277077	29/44 (66%)
		JmjC	501..617	CDD:202224	92/115 (80%)
		zf-C5HC2	707..759	CDD:280996	30/52 (58%)
		PLU-1	772..1098	CDD:285609	98/338 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1161..1181		6/19 (32%)
		PHD2_KDM5C_5D	1187..1247	CDD:277081	20/68 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1316..1371		10/73 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1444..1560		29/147 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151681
Domainoid	1	1.000	221	1.000	Domainoid score	I2615
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1252	1.000	Inparanoid score	I176
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53001
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	1	1.000	-	-		FOG0000761
OrthoInspector	1	1.000	-	-		otm40656
orthoMCL	1	0.900	-	-		OOG6_100617
Panther	1	1.100	-	-	LDO	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R628
SonicParanoid	1	1.000	-	-		X397
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800