DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and REF6

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_680116.2	Gene:	REF6 / 824002	AraportID:	AT3G48430	Length:	1360	Species:	Arabidopsis thaliana

Alignment Length:	1799	Identity:	350/1799 - (19%)
Similarity:	573/1799 - (31%)	Gaps:	682/1799 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 PECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRLNELE 223
            |..|.||||..||::|:|||.||...|.:.||.|||||.  .||                    .
plant    18 PVAPEFRPTLAEFQDPIAYILKIEEEASRYGICKILPPL--PPP--------------------S 60

  Fly   224 AKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKVANRM 288
            .||.:                |:|...:..|.|
plant    61 KKTSI----------------SNLNRSLAARAA-------------------------------- 77

  Fly   289 QYPSSKSVGATLKAHYERILHPFEVYTSGKVLGPTPTSSGSGSTPVKLEDGGGTDYKAHEIPTRQ 353
                                                         .::.|||
plant    78 ---------------------------------------------ARVRDGG------------- 84

  Fly   354 QIAPPNETNTRRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEEFKRDLLSSFNAVNSGGSP 418
                           ||    :|...|
plant    85 ---------------FG----ACDYDG-------------------------------------- 92

  Fly   419 LATGTTANTRGASQKKGGEPPALIVDPLMKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLT 483
               |.|..||   |::.|
plant    93 ---GPTFATR---QQQIG----------------------------------------------- 104

  Fly   484 SIPKGEWLCPRCVVEEVSKPQEAFGFEQAEREYTLQQFGQMADQFKQEYFR---KPVHLVPTEMV 545
                   .||| ....|.:|     ..|:..||:..:|...|..|::.|.:   |...|...| :
plant   105 -------FCPR-KQRPVQRP-----VWQSGEEYSFGEFEFKAKNFEKNYLKKCGKKSQLSALE-I 155

  Fly   546 EREFWRIVSSIDEDVTVEYGADLHTMDHGSGFPTKSSLYLLP-----------GDQ--EYAESSW 597
            |..:||  :::|:..:|||..|:    .||.|        :|           |.:  ...|::|
plant   156 ETLYWR--ATVDKPFSVEYANDM----PGSAF--------IPLSLAAARRRESGGEGGTVGETAW 206

  Fly   598 NLNNLPLLEDSILGHINADISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPG 662
            |:..:...|.|:|..:..:|.|:.:|.:||.|.|:.|.||.|||..:|:||||.|..|||||||.
plant   207 NMRAMSRAEGSLLKFMKEEIPGVTSPMVYVAMMFSWFAWHVEDHDLHSLNYLHMGAGKTWYGVPK 271

  Fly   663 SCAEQFEETMK------QAAPEL-FSSQPDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITF 720
            ..|..|||.::      :..|.: ||:    |.:..|:|:|.:.:...:|..|..|:.||||:||
plant   272 DAALAFEEVVRVHGYGEELNPLVTFST----LGEKTTVMSPEVFVKAGIPCCRLVQNPGEFVVTF 332

  Fly   721 PRAYHAGFNQGYNFAEAVNFAPADWLKMGREC------------VNHYSMLRRFCVF-------- 765
            |.|||:||:.|:||.||.|.|..:||:|.::.            |:|..:|..|.:.
plant   333 PGAYHSGFSHGFNFGEASNIATPEWLRMAKDAAIRRAAINYPPMVSHLQLLYDFVLALGSRVPTS 397

  Fly   766 -----SHDELVCKMALEPAKLTFGIATACYIDMAEMVDTEKK------LRKSLLEWGVTRAERRA 819
                 ....|..|...|..:||..:.....|...|::.:..|      |.:|..:..|....|..
plant   398 INPKPRSSRLKDKARSEGERLTKKLFVQNIIHNNELLSSLGKGSPVALLPQSSSDISVCSDLRIG 462

  Fly   820 FELVNDDERHCQECNTTCFLSAVACE--CNDKLIVCLRHYTVLCGCAPEKHTLIYRYTLDEMPLM 882
            ..|:.:.|...|          :.||  .:|.::|.|.:
plant   463 SHLITNQENPIQ----------LKCEDLSSDSVVVDLSN-------------------------- 491

  Fly   883 LQKLKVKAHSFERWLSRCRDIVDAHTPTSVTLQELQELCKEAETKKFPSSLLI--DRLNA---AA 942
              .||......|::.|.|.   .:....:.|.::.||...:||.:|..:::.:  .||.:   ..
plant   492 --GLKDTVSVKEKFTSLCE---RSRNHLASTEKDTQETLSDAERRKNDAAVALSDQRLFSCVTCG 551

  Fly   943 VEAEKCVTVIQQLGINKVRTRSDHNQEAAQYKLTMEELELFVQEIDNLCCIIDEGASVRELLVLG 1007
            |.:..||.::|.            .:.||:|.::.:            |...::..:......||
plant   552 VLSFDCVAIVQP------------KEAAARYLMSAD------------CSFFNDWTAASGSANLG 592

  Fly  1008 KQFVERSESQLQLSLESLEESELETLINEGSSLRIELQQLDLLQKRLKQCKWYKRSQGLRETSSK 1072
                   ::...|..:|.|:.::....|      :.:|.:|...|        ...|....||..
plant   593 -------QAARSLHPQSKEKHDVNYFYN------VPVQTMDHSVK--------TGDQKTSTTSPT 636

  Fly  1073 LTYQDVKNLLHIAAADLDPTD-----------PYVDKEMRKLQQIGAD--IEAWESQAAKY-FRR 1123
            :.::|...|..:|:|..|.:|           |....|.:...|.|:|  .||.:.:.:.: .:|
plant   637 IAHKDNDVLGMLASAYGDSSDSEEEDQKGLVTPSSKGETKTYDQEGSDGHEEARDGRTSDFNCQR 701

  Fly  1124 LTQQH---------ELGEIE-QFLKSASDINGQVPSHGLLKDALRKAREWLRAVEQLQQNNHVTY 1178
            ||.:.         .|.||. .|:..:.|.:.::  |....:...:..:.||....:   |.:..
plant   702 LTSEQNGLSKGGKSSLLEIALPFIPRSDDDSCRL--HVFCLEHAAEVEQQLRPFGGI---NLMLL 761

  Fly  1179 CHTLEAMIERGLNIPIQLEELSRMQGHLNSAHQWKDNTACAFLKKGTFYTLLEVLMPRSDAINID 1243
            ||.....||  ....|..|||.     :|  |:|.                             |
plant   762 CHPEYPRIE--AEAKIVAEELV-----IN--HEWN-----------------------------D 788

  Fly  1244 SDLKPRFQDDFLKEKNPAEIVASFKHAEE--QELLDMRELRRQNMNKNPMRDMFCLCKSEFRNLM 1306
            ::.:...::|                 ||  |..||..|.:..|.:......:         ||.
plant   789 TEFRNVTRED-----------------EETIQAALDNVEAKGGNSDWTVKLGV---------NLS 827

  Fly  1307 FNCQLCRDWFHEDCVPPPSATNQNGIVN---GGSGPGTNRPKWLCPSCVRSKRPR---------- 1358
            ::..|.|...:...:|      .|.|:.   |.|.|..:.|.....|..||.|.|
plant   828 YSAILSRSPLYSKQMP------YNSIIYKAFGRSSPVASSPSKPKVSGKRSSRQRKYVVGKWCGK 886

  Fly  1359 ---LETILPLLVQLQQLPIRLPEDEALRCLAERAMNWQDRARKALSSPDVSAAQEAIMAQQQQKR 1420
               ...:.|.|:: |.|.   .|:....|....||: :|...|.....:||.....:..::..::
plant   887 VWMSHQVHPFLLE-QDLE---GEESERSCHLRVAMD-EDATGKRSFPNNVSRDSTTMFGRKYCRK 946

  Fly  1421 RSEGGAGVGNISSPRKPRRRGSLTKEASGSTESDADDDDDEDECRLRIVEDNFSNDEDEPRTAPA 1485
            |        .|.:...||::.:..|...|.::..::|...:.:.|.       |.:|:|......
plant   947 R--------KIRAKAVPRKKLTSFKREDGVSDDTSEDHSYKQQWRA-------SGNEEESYFETG 996

  Fly  1486 TSTVNSDLLKLLSD-----------SEIENLLDLMMEGDLLEVSLDETQELWRILETMPPTLLQA 1539
             :|.:.|....:||           .|.|:      :.::.:.||.|..       |:.......
plant   997 -NTASGDSSNQMSDPHKGIIRHKGYKEFES------DDEVSDRSLGEEY-------TVRACAASE 1047

  Fly  1540 EAMERVVQY-----------MQRQ-----RQQHTNPLPTSGAEDSNDSLMVQNSPNSNSNSGGAT 1588
            .:||...|:           :.||     |.|.|.......:.:|.|:.:.|.|...
plant  1048 SSMENGSQHSMYDHDDDDDDIDRQPRGIPRSQQTRVFRNPVSYESEDNGVYQQSGRI-------- 1104

  Fly  1589 GSASNSGRNKKRRSNDTGGNSAVPRKKQSTPKQTPGKKGSAAAARKSDAKASPAASTTPGADADA 1653
             |.||...|:.....|:..||...|...||     ||:.:.:.|::.      |.:.|..:..|.
plant  1105 -SISNRQANRMVGEYDSAENSLEERGFCST-----GKRQTRSTAKRI------AKTKTVQSSRDT 1157

  Fly  1654 ENK---QANGGNTNSSTGSGGGNSAT------TTPTPGSTHKKRKRTSTTATNNNNNNNNNSTNN 1709
            :.:   :...|..|....|.....:|      ..|:.||...|.|:.....:.|
plant  1158 KGRFLQEFASGKKNEELDSYMEGPSTRLRVRHQKPSRGSLETKPKKIGKKRSGN----------- 1211

  Fly  1710 SNSSTNLNSNTTSGQGAATGGNNATGGQKKHAQRSQQAAQEDDEEE------CRAENC------- 1761
                             |:....||  :|...::.::..:|::|||      |..|.|
plant  1212 -----------------ASFSRVAT--EKDVEEKEEEEEEEENEEEECAAYQCNMEGCTMSFSSE 1257

  Fly  1762 -----HKPTGREVDWVQCDGGCNEWF--HMYCVGLNRSQIKPDD 1798
                 ||   |.:..::   ||.:.|  |.|.|  ...::..||
plant  1258 KQLMLHK---RNICPIK---GCGKNFFSHKYLV--QHQRVHSDD 1293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	21/40 (53%)
		ARID	227..312	CDD:198082	4/84 (5%)
		PHD1_Lid_like	450..495	CDD:277078	2/44 (5%)
		JmjC	624..740	CDD:202224	54/122 (44%)
		zf-C5HC2	830..882	CDD:280996	6/53 (11%)
		PLU-1	896..1229	CDD:285609	66/361 (18%)
		PHD2_KDM5A	1295..1351	CDD:277079	11/58 (19%)
		PHD3_KDM5A_like	1755..1805	CDD:277083	15/64 (23%)
REF6	NP_680116.2	JmjN	21..52	CDD:280526	16/30 (53%)
		JmjC	233..352	CDD:202224	54/122 (44%)
		C2H2 Zn finger	1245..1266	CDD:275368	5/23 (22%)
		C2H2 Zn finger	1268..1290	CDD:275368	6/26 (23%)
		C2H2 Zn finger	1298..1320	CDD:275368
		C2H2 Zn finger	1328..1348	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920